Agar-based Drug-Delivery Vehicle Development Service

Agar-based Drug-Delivery Vehicle Development Service at CD BioGlyco

Agar is a natural polysaccharide extracted from seaweed, mainly derived from red algae, which is composed of galactose and cysteine arranged alternately to form a chain-like polymer polysaccharide structure, this special structure gives agar excellent gel properties and biological activity. Therefore, agar is widely used as a vehicle in drug delivery systems. CD BioGlyco has extensive experience in the field of Marine Carbohydrate-based Drug-Delivery Vehicle Development, and we have top-notch vehicle preparation technology and provide reliable agar-based drug-delivery vehicle development service.

Agar Gel

Agar forms gels easily and has high gel strength and elasticity. We prepare agar gels with different concentrations and properties to achieve a controlled release of drugs by adjusting the physicochemical properties of the gel. We add an appropriate amount of agar powder to the buffer (such as phosphate buffer), heat to dissolve the agar, then mix the target drug before the solution is cooled, and finally pour the agar solution into a tray or mold, wait for the solution to solidify, and then remove the required shaped gel. Agar gel has a certain pore structure and carries a large number of drug molecules.

Agar Microspheres

We provide a mature agar microsphere-based drug delivery vehicle development service to control the release rate and delivery characteristics of the drug through the size, shape, and composition of the microspheres. We dissolve an appropriate amount of agar in the buffer and use centrifugation or spray drying to drop the agar solution into the cross-linking agent solution (such as polyethylene glycol dimethacrylate) to form agar microspheres. Finally, the agar microspheres are collected, washed, and dried.

Agar Nanoparticles

We prepare nano-sized agar particles for targeted drug delivery and increased drug stability. We dissolve an appropriate amount of agar in the buffer, use emulsification or co-precipitation methods, add drugs to the agar solution and form an emulsion or co-precipitation system with surfactants, then use ultrasonic treatment or stirring to mix the system evenly, and finally perform operations such as centrifugation or filtration to collect nanoparticles.

Agar Fiber

Agar is a polysaccharide material with good biocompatibility and does not cause obvious immune reactions or toxic side effects, which makes it potentially useful as a drug delivery vehicle, wound dressing, and artificial tissue repair in the medical field. We prepare agar materials with fibrous structures to be used as fibrous antibacterial scaffolds for wound dressings. We dissolve the appropriate amount of agar in hot water. The agar solution is then pulled through a pinhole or nozzle and stretched into a fiber shape using a spinning technique (such as electrospinning). Finally, the agar fibers are collected, washed, and dried.

In addition, we also provide comprehensive drug-loading performance evaluation services. We use mature experimental techniques to evaluate the drug-loading performance of agar vehicles, such as drug loading capacity, release rate, delayed release performance, etc.

Fig.1 Agar-based drug-delivery vehicle development service. (CD BioGlyco)

Publication

Technology: UV-visible spectrophotometer

Journal: Materials Science and Engineering: C

IF: 8.457

Published: 2017

Results: The authors exploited the heat-responsive sol-gel transition properties of agar and gelatin to prepare agar/gelatin bilayer gel beads. They added the agar solution dropwise into cold soybean oil and incubated the droplets in the oil to form single-layer agar beads. A single layer of agar beads was then mixed with the gelatin solution, and the mixture was added dropwise into cold soybean oil to produce a stable agar/gelatin bilayer of beads. In addition, the authors loaded sodium salicylate as a model drug and evaluated the release profile of sodium salicylate using a UV-visible spectrophotometer. The results showed that this agar/gelatin bilayer matrix was a new type of drug vehicle that achieved individual loading and gradual release of drugs under thermal stimulation.

Fig.2 Preparation process of agar/gelatin bilayer of beads. (Wang, et al., 2017)

Applications

• Protein delivery: Agar as a vehicle stabilizes and delays the release of proteins and is used in protein delivery systems, such as protein drug delivery, biomaterial repair, etc.
• Cell culture: Agar matrix provides a three-dimensional scaffold for cell culture and tissue engineering research to promote cell proliferation and differentiation.
• Drug sustained-release system: Agar vehicle is used to prepare drug sustained-release systems to achieve controlled release of drug.

Advantages

• CD BioGlyco has extensive experience in the biomedical field and leading quality standards, we provide professional agar-based drug delivery vehicle solutions.
• CD BioGlyco has mature technology means and strong R&D strength. We respond quickly to client needs and provide clients with high-quality agar-based drug delivery vehicle development services.
• CD BioGlyco has established a stable and reliable agar supply chain, with stable raw material sources and sustainable production capabilities.

As a leading global biotechnology company, CD BioGlyco focuses on developing and providing high-level marine carbohydrate-based drug delivery vehicle development services, such as Alginate, Carrageenan, Fucoidan, and agar. Please feel free to contact us if you would like to obtain detailed development content.