Galactan-based Drug-Delivery Vehicle Development Service

Galactan-based Drug-Delivery Vehicle Development Service at CD BioGlyco

Galactan is obtained from various sources such as plant cell walls and seaweed, which usually consists of galactose units linked by α-1,4- or β-1,3-linkages. Research has found that galactan has various biological activities such as anti-tumor, anti-inflammatory, and antioxidant. Based on these features, CD BioGlyco provides a professional galactan-based drug-delivery vehicle development service. Moreover, we select diversified sugar units for vehicle design, such as Laminaran, Agar, Chitosan, etc., and provide flexible Marine Carbohydrate-based Drug Delivery Vehicle Development services to achieve effective encapsulation and controlled release of drugs.

• Galactan Nanoparticle
  • Synthesis: We synthesize galactan structures through chemical synthesis or enzymatic methods, such as galactan polymers. Moreover, the size and morphology of nanoparticles are controlled by changing reaction conditions, ligand selection, and cross-linking agents.
  • Drug loading: We encapsulate drugs and galactan nanoparticles, usually using methods such as blending, electrostatic adsorption, or covalent bonding.
  • Characterization and evaluation: We use techniques such as dynamic light scattering and transmission electron microscopy (TEM) to characterize the particle size, zeta potential, morphology, and stability of nanoparticles, we evaluate the encapsulation efficiency and controlled release characteristics of the drug through the centrifugal deposition.
• Galactan Hydrogel
  • Synthesis: We synthesize a galactan hydrogel structure with cross-linking ability through chemical cross-linking or physical cross-linking. For example, a cross-linked network structure is formed by reacting galactan with a cross-linking agent (such as a dialdehyde compound).
  • Drug loading: We embed drugs into the hydrogel structure or saturate the drug into the hydrogel via physical adsorption.
  • Characterization and evaluation: We use scanning electron microscopy (SEM), dynamic mechanical analysis, and other techniques to characterize the morphology, swelling degree, and mechanical properties of the hydrogels. The drug release behavior and hydrogel stability are evaluated through in vitro dissolution experiments.
• Galactan Liposome
  • Synthesis: We covalently bind galactan to the liposome surface through chemical modification, for example, using active esterification agents or cross-coupling reagents to bind galactan to the hydroxyl or amine groups on the liposome surface.
  • Drug loading: We encapsulate target drugs inside liposomes via static mixing, thin film methods, or dialysis.
  • Characterization and evaluation: We use a particle size analyzer, zeta potential analyzer, and other technologies to characterize the particle size, zeta potential, and stability of liposomes, and evaluate the release characteristics of the drug through in vitro release experiments.

In addition, we also provide biocompatibility and safety assessment for the developed drug delivery vehicles, such as cytotoxicity testing, animal model studies, and pharmacokinetic studies to ensure that they will not cause toxic side effects when used in vivo.

Fig.1 Galactan-based drug-delivery vehicle development service. (CD BioGlyco)

Publication

Technology: An aqueous casting procedure

Journal: International Journal of Biological Macromolecules

IF: 8.025

Published: 2023

Results: Halloysite (HNT) had hollow tubular-shaped cavities that were filled with bioactive molecules. Funori was a natural polymer extracted from the red seaweed Gloiopeltis, which was a sulfated galactan. The authors prepared a Funori/HNTs nanocomposite film through an aqueous casting procedure, and the film was loaded with diclofenac sodium. The authors studied the release kinetics of diclofenac sodium from composite films with different HNT concentrations. The results showed that the release rate of Funori/HNT nanocomposite film was slow, and different concentrations of HNT didn't significantly affect the release of the drug.

Fig.2 Release profile of diclofenac sodium from Funori/HNT nanocomposite film. (Cavallaro, et al., 2023)

Applications

• Anti-infective drug delivery: Galactan is used as a drug delivery vehicle to deliver antibiotics, antiviral drugs, or other anti-infective agents. It improves the solubility and stability of drugs, achieves controlled release, and prolongs the presence of drugs at the site of infection.
• Hematopoietic stem cell transplantation: As a supportive vehicle, galactan provides a suitable environment to protect and promote the survival and proliferation of stem cells, thus increasing the success rate of transplantation.
• Vaccine delivery: Galactan is used as a delivery system for vaccines, which stably encapsulates vaccine antigens inside and improves vaccine absorption and immune response by targeting receptors on the surface of specific immune cells.

Advantages

• Diversified vehicles: We provide multiple types of galactan vehicle development services to adapt to the characteristics and release needs of different drugs.
• Advanced R&D technologies: We are equipped with advanced R&D technologies to provide comprehensive galactan-based drug delivery vehicle preparation, performance evaluation, and drug release research services.
• Efficient delivery: We respond quickly to client needs and provide efficient product delivery time to ensure project progress and client satisfaction.

CD BioGlyco has unique technical means and rich industry experience to provide high-performance galactan-based drug delivery vehicle development services. We provide a variety of galactan delivery vehicles and flexible solutions. Please feel free to contact us if you are interested in knowing the details of our vehicle preparation.