Accelerate Chitooligosaccharide (COS) Research: Try Our Comprehensive Characterization Service
COS is a low molecular weight polymer derived from the degradation of Chitosan by different methods and has a variety of biological activities and a wide range of applications. CD BioGlyco perfects the means of characterizing Marine Carbohydrates and provides a high-quality COS characterization service. Our team consists of researchers with extensive experience in the Characterization of Marine Animal Polysaccharides and provides customized solutions.
COS characterization service applies to a wide range of sample types, research, and application needs. Combining a variety of extraction techniques and analytical tools, we mainly provide the following services:
Extraction
We use physical degradation, chemical degradation, and enzymatic methods to prepare COS. The biological activity of COS may vary greatly depending on the molecular weight and degree of deacetylation. We design customized preparation methods according to the specific requirements of our clients.
- Physical degradation: COS prepared by this method (ultrasonic, microwave, etc.) is of high purity.
- Chemical degradation method: This method mainly consists of oxidative degradation and acid degradation, which is easy to operate.
- Enzymatic degradation method: This method is specialized and easier to operate.
Characterization
We provide a comprehensive COS physical and chemical characterization service and have developed a series of analytical methods and testing systems for the analysis.
- Compositional analysis: Chemical compositional analysis is important for the study of the conformational relationship of COS. We use a variety of techniques to analyze the molecular weight, degree of polymerization, sequence, and other basic characteristics of COS.
- High-performance liquid chromatography (HPLC): This technique is used for the determination and analysis of the degree of polymerization.
- Mass spectrometry (MS): This technique is commonly used to analyze COS and is used to analyze the degree of polymerization, sequence, and molecular weight of COS and its derivatives.
- Structural analysis: We combine a variety of advanced techniques to analyze the physicochemical properties and degree of acetylation of COS samples, including nuclear magnetic resonance (NMR), MS, Infrared radiation (IR), etc.
Applicable Samples
Clients are required to provide samples of raw materials, crude extracts, or further purified COS.
Delivery of Results
We provide complete isolation purification and characterization reports of raw analytical data, including the COS isolation purification process, molecular weight distribution determination, etc., and ensure timely pre-sales and after-sales service support.
Publication Data
Technology: NMR, MS
Journal: International Journal of Molecular Sciences
IF: 4.183
Published: 2018
Results: This paper describes in detail the various methods of COS preparation, techniques for analyzing the structure and composition of COS, and the biological activity of COS. Different methods are applied for COS preparation, including physical, chemical, and enzymatic methods, with their advantages and shortcomings. Techniques such as MS and NMR are used to analyze the extracted COD. It is found that the molecular weight etc., of COS affects its application in biomedicine and other fields. The establishment of processes and characterization methods for producing well-defined COS is essential for tapping its biological activities and applications. These preparative methods and analytical techniques described in the paper guide the optimization and characterization of COS preparation methods.
Fig.1 Preparation and analysis of COS. (Liang, et al., 2018)
Applications
- Analysis of COS composition and structure plays an important role in optimizing its manufacturing process.
- The analysis of the composition and structure of COS plays a role in the development of COS-based drug delivery systems.
- The analysis of the composition and structure of COS plays an important role in the development of nutraceuticals and functional foods.
Advantages
- Our characterization of COS structure and composition is reproducible and highly accurate.
- Our COS characterization is very comprehensive and we provide detailed structural analysis reports.
- Our COS characterization service is thoughtful, and we provide timely after-sales technical support.
Frequently Asked Questions
What are the biological functions of COS?
Based on its good biocompatibility, low molecular weight, and other advantages, COS has a variety of biological activities, such as antioxidant, neuroprotective effects, antitumor, and immunomodulation. For example, COS increases the phagocytic activity of macrophages, and it also has some antibacterial activity, which has great potential for application in the development of new antifungal drugs.
What information does a client need to provide when inquiring about COS characterization service?
You need to tell us your specific experimental goals, sample type and purity, and desired project period. After communication, we will provide detailed information about sample requirements, experimental protocols, pricing, experimental cycle time, and related technologies.
COS has a wide range of applications in various fields such as food, biomedical, etc., and has good and excellent properties and biological activities. CD BioGlyco provides a one-stop COS characterization service to support our clients' various research. Welcome to contact us for detailed analytical procedures if you need this area.
Reference
- Liang, S.; et al. A review of the preparation, analysis and biological functions of chitooligosaccharide. International journal of molecular sciences. 2018, 19(8): 2197.
