Laminaran-based Drug-Delivery Vehicle Development Service

Laminaran-based Drug-Delivery Vehicle Development Service at CD BioGlyco

Laminaran is a nontoxic, hydrophilic, biodegradable polysaccharide isolated from the cell wall of brown seaweed and is composed of glucose monomers linked together by (1, 3) β-glucan and (1, 6) glycosidic bonds. Laminaran has two types of polymer chains terminated with D-mannitol residues (M series) and D-glucose residues (G series), It has a wide range of biological activities such as anti-tumor, antioxidant, and immune regulation. CD BioGlyco focuses on researching laminaran, and we provide professional laminaran-based drug-delivery vehicle development services.

• Diverse vehicle preparation service
  • Laminaran nanoparticles: We convert laminaran into nanoscale particles through nanotechnology, usually using methods such as solvent precipitation, emulsification, gelation, etc. These nanoparticles are used as drug vehicles to achieve controlled release and targeted delivery.
  • Laminaran nanomicelles: We combine laminaran with surfactants to form micellar structures in aqueous solutions. This vehicle has a small particle size and good stability, which effectively encapsulates and delivers water-soluble drugs.
  • Laminaran nano gel: We form laminaran into a gel structure through cross-linking or gelation technology, which has a highly absorbent and tunable pore structure, making it suitable for controlled drug release and tissue engineering applications.
  • Laminaran nanofibers: We use nanofiber technology to prepare laminaran into a fibrous structure. This nanofiber vehicle has a large specific surface area and good biocompatibility, which is used in the fields of drug delivery and tissue repair.
  • Laminaran nanoliposomes: We combine laminaran with lipids to form nanoscale liposome structures, which have good drug encapsulation and biocompatibility, which are often used in drug delivery and imaging applications.
• Drug delivery vehicle construction service: We effectively load target drugs onto different types of laminaran vehicles through methods such as adsorption, encapsulation, or chemical coupling.
• Characterization and analysis service: We characterize the obtained laminaran-based drug-delivery vehicle. Common characterization methods include particle size analysis (such as dynamic light scattering), morphology observation (such as transmission electron microscopy or scanning electron microscopy), stability testing, etc.
• Compatibility assessment service: We evaluate the release behavior and rate of the drug in the vehicle through in vitro release experiments, and evaluate the biocompatibility and safety of laminaran-based drug-delivery vehicle through in vitro and in vivo models, including evaluation of cytotoxicity, inflammatory response, etc.
• Targeted strategy development service: In addition, according to client needs, we carry out targeted modifications to laminaran vehicles, such as introducing targeting molecules, surface modifications, etc. We transform the laminaran vehicle into a drug delivery system that may target specific cells, tissues, or diseased sites to achieve targeted delivery.

Fig.1 Laminaran-based drug-delivery vehicle development service. (CD BioGlyco)

Publication

Technology: Co-precipitation

Journal: Environmental Research

IF: 8.431

Published: 2022

Results: The authors synthesized nanoparticles with laminaran as a capping agent (Lm-ZnO NPs) and chitosan-capped nanocomposites (Ch-Lm-ZnO NCmps) through a co-precipitation method, They conducted a variety of physical and chemical characterizations and cell toxicity studies. The cytotoxicity results in vitro showed that Lm-ZnO NPs and Ch-Lm-ZnO NCmp significantly inhibited cell viability in a dose-dependent manner, which suggested their potential application as nanotherapeutics for the research of cancer.

Fig.2 In vitro cytotoxicity results. (Vijayakumar, et al., 2022)

Applications

• Disease targeting: Laminaran polysaccharide nanoparticles will specifically deliver drugs to specific tissues or cells, thereby improving the therapeutic effect and reducing adverse effects on healthy tissues.
• Contrast agent delivery: Imaging materials such as fluorescent dyes are encapsulated in laminaran nanoparticles, which provide high-contrast images and be used for monitoring in medical imaging.
• Bone tissue engineering: Bone repair drugs and growth factors are incorporated into the laminaria matrix and prepared into a scaffold or gel, which helps promote the regeneration and repair of bone tissue.

Advantages

• Proven experience: We have extensive experience and success stories in the field of nanomedicine delivery, address various challenges, and provide solutions.
• Advanced technology means: We have advanced technology means, which carry out key steps such as the preparation, drug loading, and characterization of laminaran nanoparticles.
• Flexibility and response speed: We have the flexibility and quickly provide drug delivery vehicle development service according to client needs.

CD BioGlyco is equipped with powerful technical teams to support diverse Marine Carbohydrate-based Drug-Delivery Vehicle Development Service, who provide you with high-quality laminaran-based drug-delivery vehicle development service. Please feel free to contact us if you would like to inquire about the details of the development.