Keratan Sulfate-based Drug-Delivery Vehicle Development Service

Keratan Sulfate (KS) contains a disaccharide unit consisting of galactose and 6-position O-sulfated acetyl glucosamine residues. The hydroxyl groups beyond the 6-position of the acetylglucosamine residue of Marine Carbohydrate-derived KS are further sulfated, resulting in the formation of polysulfated keratan sulfate. Therefore, KS from Marine Animals has stronger anti-inflammatory and immunosuppressive effects. Based on this property, CD BioGlyco offers a professional KS-based drug-delivery vehicle development service to clients.

KS-based Drug-Delivery Vehicle Development Service at CD BioGlyco

CD BioGlyco has a professional Marine Carbohydrate-based Drug-Delivery Vehicle development team. We offer the following services:

• KS Preparation and Physicochemical Property Determination
  We efficiently separate KS and impurities by combining an ion exchange column and high-performance liquid chromatography (HPLC). For purified KS, we provide component identification services such as glucuronic acid content analysis, molecular weight determination, organic sulfate determination, etc. Notably, high-purity KS is key to the success of the subsequent drug-delivery vehicle.
• Synthesis and Characterization Service
  We provide a variety of keratan sulfate-based drug-delivery vehicle synthesis services such as nanoliposomes, microspheres, microcapsules, nanoparticles, etc. These forms of drug-delivery vehicles greatly improve the convenience of medication and increase the efficacy while reducing the side effects. Our research group continuously optimizes production conditions through orthogonal design, focusing on evaluating the effects of solution concentration, pH, molecular weight, and others on drug-delivery vehicle synthesis.
  For keratan sulfate-based drug-delivery vehicles, we provide a range of characterization services e. g., vehicle volume, surface potential, etc. In addition, we offer Fourier transform infrared spectrometer (FTIR) analysis, nuclear magnetic resonance (NMR) analysis, and dynamic light scattering (DLS) analysis services.
• In Vitro Analysis Service
  Our talented team has extensive experience in bioactivity analysis. The in vitro drug release efficiency of the drug-delivery vehicle is measured by dialysis. At a predetermined time point, the medium is sampled to calculate the cumulative release of the drug. Meanwhile, we care a lot about in vitro cytotoxicity assay service. We compare the in vitro cytotoxicity of cancer cells and blank group by MTT assay. In addition, we use flow cytometry to provide cellular uptake mechanism study services. Our analysts help our clients to fully analyze the data processing and provide professional analysis reports for them.
• In vivo activity analysis service
  By making the animal model, we set up the model group, positive control group, negative control group, and sample administration group, and gave drugs and tested different indicators to determine the effect.

Fig.1 Flow chart of KS-based drug-delivery vehicle development. (CD BioGlyco)

Applications

• KS-based drug-delivery vehicle well suited to deliver anti-rheumatoid arthritis drugs.
• KS-based drug-delivery vehicles can be used as an effective transportation mode for anti-inflammatory agents, anti-allergic agents, and immunomodulatory agents.
• We help our clients develop new KS-based cancer drug delivery vehicles to achieve selective drug effects where needed, sparing other parts of the body from side effects, and bringing a new perspective to cancer treatment.

Advantages of Us

• A research team led by experienced Ph. D.s will develop detailed experimental plans based on your needs, and adjust and optimize the plans promptly during actual operations.
• We provide a series of services from protocol design, high-purity KS preparation, synthesis, and characterization to in vivo and in vitro biological activity analysis.
• Our researchers ensure service integrity through efficient delivery and accurate release.

CD BioGlyco provides comprehensive marine glycobiology development services. We are committed to being your best partner in the field of marine glycobiology. Moreover, we provide reliable Chondroitin Sulfate, Dermatan Sulfate, and Heparan Sulfate-based drug-delivery vehicle development services. To learn more information about KS-based drug-delivery vehicles, please feel free to contact us.