Marine Biomolecule Production Service

Our Manufacturing Process of Marine Biomolecules

First and foremost, we tailor the solution to meet the specific needs and requirements of our clients. By carefully assessing their preferences and objectives, we create a customized plan that aligns perfectly with their expectations. Our comprehensive process comprises several stages, starting with the pre-treatment of raw materials, followed by extraction, separation, and concentration, and ultimately culminating in the purification of the desired functional biomolecules.

Fig.1 The manufacturing process of marine biomolecules. (CD BioGlyco)

At CD BioGlyco, we provide clients with many kinds of marine biomolecules.

Marine Carbohydrate Production Service

Technologies for the Production of Marine Carbohydrates

CD BioGlyco provides a wide range of services to ensure the production of high-quality and pure carbohydrates. Our expertise spans various technologies dedicated to the production of marine carbohydrates and the purification of marine polysaccharides. Therefore, we offer a diverse selection of technologies for the production of marine carbohydrates.

Our Technologies for the Purification of Marine Polysaccharides

We also possess cutting-edge technologies for the purification of marine polysaccharides to ensure superior quality and purity. These advanced methods eliminate impurities while preserving the unique properties of the compounds. We are constantly improving and expanding our technology and knowledge, and enhancing our skills and capabilities. Our technologies for the purification of marine polysaccharides include but are not limited:

• Chromatography Purification of Marine Polysaccharides
• Column chromatography purification of marine polysaccharides: Anion-exchange chromatography purification of marine polysaccharides; Gel-filtration chromatography purification of marine polysaccharides; Cellulose column chromatography purification of marine polysaccharides; Macroporous resin chromatography purification of marine polysaccharides.
• Affinity chromatography purification of marine polysaccharides
• Precipitation Purification of Marine Polysaccharides
• Quaternary ammonium salt precipitation purification of marine polysaccharides
• Graded precipitation purification of marine polysaccharides
• Alcohol precipitation purification of marine polysaccharides
• Zone Electrophoresis Purification of Marine Polysaccharides
• Salting-out Purification of Marine Polysaccharides
• Metal Coordination Purification of Marine Polysaccharides
• Ultracentrifugation Purification of Marine Polysaccharides
• Membrane Filtration Purification of Marine Polysaccharides
• Preparative Gel Electrophoresis Purification of Marine Polysaccharides

By using various technologies, we continuously innovate our methods to efficiently extract and utilize the polysaccharides present in marine sources such as marine plants, marine animals, and marine microorganisms.

Marine Plant Polysaccharide Production Service

We provide a diverse selection of polysaccharides sourced from marine plants, each polysaccharide possesses a wide spectrum of biological activities. Our marine plant polysaccharide production service includes:

• Alginate Production Service: We produce alginate from brown seaweeds as a source by acidification, and alkaline extraction using sodium carbonate, followed by solid/liquid separation, precipitation, drying, and purification processes.
• Fucoidan Production Service: We use diverse brown algae to extract various fucoidans that display different structures and bioactivities. Extensive research has been conducted on the growth environment, distribution of bioactive compounds, and chemical structures of each plant. By utilizing this information, we have developed specific extraction methods for each type of polysaccharide and are continuously adjusting and optimizing them based on experimental results. With our personalized approaches, we will help clients to extract fucoidan efficiently.

• Laminarin Production Service: Laminarins are a type of storage β-glucans with low molecular weight. They consist of (1,3)-β-d-glucan units. They have the potential to be functional ingredients in the food research. Therefore, we offer laminarin production from diverse sources, including Laminaria, Saccharina, Fucus, Ascophyllum, and Undaria.
• Carrageenan Production Service: We produce many types of carrageenan that can be derived from algae. They are polysaccharides with significant economic potential across multiple industries. There is a wide variety of carrageenans in our production, including kappa (κ) carrageenan, iota (ι) carrageenan, lambda (λ) carrageenan, mu (µ) carrageenan, nu (ѵ)carrageenan, theta (θ) carrageenan, xi (ξ) carrageenan, alpha (α) carrageenan, beta (β) carrageenan, gamma (γ) carrageenan, omega (ω) carrageenan, and psi (Ψ) carrageenan.

In addition to producing the aforementioned common marine polysaccharides, we also provide manufacturing services as follows.

• Sulfated Polysaccharide Production Service: We also provide some polysaccharides that have sulfated functional groups attached to their structure. We utilize efficient extraction or precipitation methods to obtain them, then we conduct purification, characterization, and biological studies. We will manufacture these biologically active polysaccharides for clients.

Marine Animal Polysaccharide Production Service

Marine animals are also a great source of polysaccharides, and we utilize this abundant resource to produce animal marine polysaccharides, such as chitin, chitosan, and chitooligosaccharides. By enzymatic deacetylation using chitin deacetylases, we will achieve biotransformation of chitin into chitosan. We use many kinds of methods to produce chitooligosaccharides from chitin and chitosan, such as physical, biochemical, electrochemical, or enzymatic approaches. Besides, chitosan and chitooligosaccharides can also be directly extracted from marine animals.

We also produce various marine animal glycosaminoglycans with distinct properties that differ from those found in terrestrial organisms.

Marine Microbial Polysaccharide Production Service

Microbial polysaccharides derived from marine species have received significant attention for their use in a variety of fields such as medicine, pharmaceuticals, and food due to their wide structural and functional diversity displayed by microbial polysaccharides derived from marine species. We mainly focus on the production of four kinds of marine microbial polysaccharides.

Marine Glycoprotein Production Service

Marine glycoproteins have gained significant attention due to their potential applications for the research of medicine, cosmetics, and food development. CD BioGlyco offers the manufacture of glycoproteins in marine organisms and fully explores their various characteristics for further development and utilization. By using effective separation and purification techniques, we have succeeded in obtaining marine glycoproteins in high yields, ensuring a wide range of products and excellent quality. By delving deeper into understanding the functions of marine glycoproteins, we lay a strong foundation for maximizing their potential and harnessing marine resources more effectively.

We achieve the production of the following marine glycoproteins, including but not limited to:

In addition, we use several methods for the production of marine collagen including salt precipitation method isolation, acid-soluble method isolation, and enzyme-soluble method isolation.

Marine Lectin Production Service

At CD BioGlyco, we provide the production of marine lectins by extracting them primarily from various types of marine organisms, including:

Besides, we are dedicated to enhancing the efficiency of lectin extraction methods to maximize bioavailability. With a keen focus on sustainability and innovation, we strive to maximize the efficiency of protein extraction techniques. To ensure consistent excellence, we employ a multidimensional approach that encompasses cutting-edge technologies for comprehensive product characterization. Our state-of-the-art analytical tools and methodologies allow us to delve deep into the structural and functional properties of our marine lectins. Through rigorous quality control processes, we guarantee that our products meet the highest standards of purity, potency, and bioactivity.

Marine Glycoside Production Service

CD BioGlyco realizes the production of marine organism glycosides by using sea cucumber, starfish, sponge, alga, and coral. These marine glycosides possess a variety of biological activities including antifungal activity and antitumor activity. We also provide bioactivity analysis through our advanced technological platform.

We use the rich bioactivities of marine glycosides to assist clients in developing and researching innovative medicines. By deeply studying and analyzing the active components of marine glycosides, we will provide comprehensive solutions for glycoside modification to our clients. With our leading-edge technology and expertise, we will discover and harness the unique pharmacological effects offered by marine glycosides to meet the client’s needs for research of efficient, safe, and innovative therapies.

We offer a variety of glycoside production, as shown in the diagram below. We are not limited to the production of the glycosides listed below, and if clients are interested in other glycosides, we will also provide customized production.

Marine Glycolipid Production Service

CD BioGlyco applies various methods for the production of a wide array of glycolipids, with a significant emphasis on sourcing them from various marine organisms. Based on the lipidic component, we classify these glycolipids into three primary categories:

While glycoglycerolipids are predominantly found in microorganisms and plants, glycosphingolipids are widely present in all organisms. By using these abundant marine animals, microorganisms, and plants, we will help clients produce dozens of marine glycolipid compounds mentioned above. Besides, we have broadened our range of glycolipid production by harnessing the immense potential of total synthesis methods, allowing us to unlock a diverse array of structurally complex and biologically significant glycolipids.

Our Scale of Production

We ensure that the marine biomolecules we manufacture exhibit a high degree of precision and purity. Our marine carbohydrate characterization service utilizes state-of-the-art technologies to guarantee these qualities. At CD BioGlyco, we possess the ability and resources to manufacture marine biomolecules on both a laboratory-scale and large-scale industrial basis, ensuring we meet the diverse needs of our clients.

Fig.2 The diagram of production scale. (CD BioGlyco))

• In certain cases, the properties of these marine biomolecules may not meet the specific requirements for applications. Consequently, we provide marine carbohydrate modification services to modify their structure, either chemically or physically, to enhance their physical-chemical properties.
• To provide clients with a deeper understanding of the properties of marine biomolecules, we have also launched the Bioactivity Analysis of Marine Glycan&Glycoprotein. This service is designed to explore the bioactivities of these compounds and their interactions within biological systems.

Fig.3 Our analysis services of bioactivities. (CD BioGlyco)

In addition, we also provide some other services related to marine biomolecules, including:

• Marine Carbohydrate Characterization Service
• Marine Glycomics Service
• Marine Glycoproteomics Service
• Marine Carbohydrate Modification Service
• Marine Glycoenzyme Development Service
• Marine Glycoconjugate Development Service
• Marine Carbohydrate-based Drug-Delivery Vehicle Development Service
• Marine Carbohydrate-based Vaccine Development Service
• Marine Carbohydrate-based Adjuvant Development Service
• Marine Carbohydrate-related Biomarker Development Service
• Marine Carbohydrate Mimetic Development Service
• Marine Carbohydrate-based Biomaterial Engineering Development Service

Publication Data

Technology: Chromatography, Activity assays

Journal: International Journal of Biological Macromolecules

IF: 8.2

Published: 2013

Results: In this research, a high molecular weight polysaccharide (HEP) was synthesized from Enteromorpha linza. Subsequently, this polysaccharide was degraded to obtain a lower molecular weight derivative (LEP). Sulfated derivatives of LEP were synthesized with high degrees of substitution (DS) using chlorosulfuric acid in formamide. The structure of the samples was analyzed using Fourier-transform infrared spectroscopy (FTIR) and methylation analyses. The anticoagulant activity of the resulting polysaccharide sulfates was assessed through coagulation assays such as prothrombin time (PT), activated partial thromboplastin time (APTT), Heptest, and thrombin time (TT), which measure their effects on various stages of the coagulation cascade. The antioxidant activities of the samples were also evaluated in vitro, and the relationship between antioxidant activity and chemical characteristics was determined.

Applications

• Marine biomolecules can be used effectively in biomedical and pharmaceutical research, particularly in the research of drug delivery, due to their intrinsic biocompatibility and potential for cost reduction.
• Marine biomolecules have been widely utilized in the research and development of cosmetics, arousing the interest of diverse populations across different nations since ancient times.
• Marine biomolecules display the significant potential to act as an effective stabilizer, or as a thickening or an emulsifying agent.

Advantages

• We generate marine biomolecules on laboratory-scale production as well as large-scale production.
• We have established a one-stop production process that includes manufacturing, characterization, activity analysis, and more.
• We offer prompt and dependable post-sales services to ensure your peace of mind.

CD BioGlyco is a known company dedicated to producing marine biomolecules, we strive to provide clients with the highest quality products and services. We carefully select natural ingredients from oceans around the world and extract pure marine biomolecules through advanced methods. We exercise strict control over raw material collection and precise extraction to ensure the highest standards by utilizing advanced technology. Our team is ready to answer any questions you may have and offer personalized advice and support. So do not hesitate to contact us now!