Marine Glycoconjugation Service

Marine Glycoconjugation Service at CD BioGlyco

Marine glycoconjugates play important biological functions in organisms, such as cell recognition, signal transduction, and immune response. CD BioGlyco has a professional technical team, comprehensive and powerful solutions, and rich experience to provide clients with high-quality marine glycoconjugation service. Our service content includes but is not limited to the following.

• Glycoprotein conjugation: We use chemical reactions, enzyme catalysis, or genetic engineering methods to connect marine sugars to proteins to form glycoprotein complexes, which have a wide range of applications in the biomedical field.
• Glycopeptide conjugation: We link marine sugars to peptides to form glycopeptide conjugates, which are used in drug delivery systems or vaccine design to improve specific recognition of cells or the immune system.
• Glyconucleic acid conjugation: We link marine sugars to nucleic acids (DNA or RNA) to form glyconucleic acid complexes, which are achieved chemically, enzymatically, or genetically.
• Glycopolymers conjugation: We combine marine sugars (such as kelp acid) with synthetic polymers (such as polyethylene glycol) to form glycopolymer complexes. This coupling is accomplished by chemical reaction or in situ polymerization. Glycopolymer complexes are used as drug delivery systems, tissue engineering materials, or biosensors.
• Glycolipid conjugation: We combine marine sugars with lipid molecules to form sugar-lipid complexes. This conjugation is achieved by chemical synthesis methods or by extraction and modification of natural marine glycolipids.
• Sugar fluorescent dye conjugation: We combine marine sugars with fluorescent dyes to form fluorescently active sugar molecule complexes. This coupling is usually achieved through chemical reactions or click chemistry methods. The complexes are used for biological imaging, analysis, and detection, such as visualization and quantification of intracellular sugars.
• Sugar immobilization service: We immobilize marine sugar molecules on material surfaces or carriers to achieve specific applications. For example, marine sugars are immobilized on the surface of nanoparticles for cell imaging and targeted delivery; or marine sugars are immobilized on solid supports and used as catalysts for sugar chemical reactions.
• Custom marine glycoconjugation service: We also provide custom coupling for specific sugars and target compounds according to client needs. Additionally, for conjugated marine glycoconjugates, we offer specialized Marine Glycoconjugate Profiling and Characterization services.

Fig.1 Marine glycoconjugation service. (CD BioGlyco)

Publication

Technology: Separation and spectroscopy techniques

Journal: Marine Drugs

IF: 6.085

Published: 2012

Results: The authors discussed the structural diversity, taxonomic distribution, and biological functions of sponge glycosides. About 170 species of spongosides were isolated from sponges from the order Astrophorida and Poeciloscleida using various separation and spectroscopic techniques. Different sponge glycosides had a variety of aglycones, including alicyclic bicyclic, tricyclic, or tetracyclic aglycones. Rare sugars such as L-quinovose and 6-deoxy-D-talose as well as many common monosaccharides were found in the carbohydrate portion of sponge glycosides. At the same time, the author pointed out that a variety of sponge glycosides isolated had antiprotozoal, antifungal, and antitumor activities.

Fig.2 Structural examples of sponge glycosides isolated. (Kalinin, et al., 2012)

Applications

• Drug Delivery System: Marine sugar combines with drug molecules to increase the stability, targeting, or solubility of the drug, thereby improving the drug delivery effect.
• Vaccine Development: Conjugation of marine sugars with immunogens improves vaccine stability, antigen presentation efficiency, and immune memory effects. Marine-derived polysaccharides are also widely applied in the design and development of glycosylated vaccines.
• Tissue Engineering Materials: Combining marine sugar with synthetic polymers or natural matrix materials improves the biocompatibility, cell adhesion, and tissue regeneration capabilities of the materials. This coupling is used to construct biomimetic tissue engineering scaffolds, materials that repair damaged tissue or promote cell proliferation and differentiation.

Advantages

• Advanced technology means: CD BioGlyco has advanced technical methods, that conduct complex marine glycoconjugate reactions and analysis.
• Diverse sugar selection: CD BioGlyco provides marine sugars from different sources and selects the most suitable sugars for conjugation according to client needs.
• Custom service: We provide custom marine glycoconjugation service, including different types of sugar modifications, conjugation methods, and scales.

CD BioGlyco has extensive experience and professional technical teams in the field of marine glycochemistry and glycobiology, and we provide excellent marine glycoconjugation service. In addition, we provide commercialization support to help clients transform marine glycoconjugation technology into practical applications and product development. Please feel free to contact us if you would like to acquire specific details.