Marine Glycolipid Production Service

We categorize our services into three main groups that glycolipids can be classified into according to the nature of the lipidic fragment. These groups are glycoglycerolipids, glycosphingolipids, and other glycolipids with unique lipidic moieties. We further elaborate on the classification of our services using the following descriptions.

Marine Glycosphingolipid Production Service

For marine glycosphingolipids, we provide services for the production of some neutral glycosphingolipids and acidic glycosphingolipids.

Marine Glycoglycerolipid Production Service

For marine glycoglycerolipids, whose core structure is comprised of 1,2-diacyl glycerol attached to a mono- or an oligosaccharide molecule, we mainly offer the production of four types of these compounds.

Marine Atypical Glycolipid Production Service

For other marine atypical glycolipids, we provide customized services for specific research and analysis based on the client's needs. Our goal is to provide extensive research support and solutions for our clients based on different categories of glycolipids. Our services include but are not limited to the following compounds:

These marine glycolipids we produce play crucial roles in cell growth, cellular recognition, adhesion, neuronal repair, and signal transduction, which are vital for maintaining overall health. Moreover, they are implicated in various diseases such as cancer, inflammatory processes, and infections.

• To gain a comprehensive understanding of their structures, we will explore the factors above that exert influence, including the type of sugar, the position at which the lipid is linked to the sugar, the length, and position of the acyl chain, as well as the configuration of the sugar's anomeric center based on our Characterization Service. At CD BioGlyco, we conduct the study of these factors to enhance our understanding of marine glycolipids.
• In addition, our analysis service at CD BioGlyco also enables us to Evaluate the Biological Activities of these marine glycolipids and analyze the relationship between their structure and activity. The analysis is vital for researchers as it establishes the groundwork for drug development by identifying lead compounds.
• Our advanced testing methodologies help clients assess the impact of various glycolipid structures on their potential biological effects. By studying how different sugars, lipid positions, acyl chains, and anomeric configurations contribute to the bioactivity of these compounds, we will identify key structural motifs associated with desired therapeutic properties.
• With a deeper understanding of the structure-activity relationship, we also offer Modification Services to assist clients in designing and optimizing drug candidates, improving their efficacy and safety profiles.

Publication Data

Technology: Total synthesis, Glycosylation reaction, Staudinger reaction

Journal: RSC Adv

Published: 2014

IF: 3.9

Results: The article described a synthesis method for ganglioside Hp-s1, which is typically isolated from the ovary of the Diadema setosum sea urchin or the sperm of the Hemicentrotus pulcherrimus sea urchin. This ganglioside possesses a Neu5Ac α2 → 6Glcβ1 → 1Cer structure. Instead of relying on these somewhat scarce natural sources, the authors presented a straightforward method for synthesizing ganglioside Hp-s1 from readily available phytosphingosine, sialic acid, and D-glucose. The synthesis involved glycosylation reactions, a Staudinger reaction, amidation, and global deprotection as key steps. Remarkably, the authors achieved an overall yield of 21.5% and 9.6%, starting from phytosphingosine or D-lyxose, respectively, in just 10 steps. By establishing the three chiral carbons of the ceramide part and connecting the glycan and ceramide parts with relatively high yield, this synthesis approach represents a promising route not only to produce ganglioside Hp-s1 but also explore other related bioactive glycolipids.

Applications

• Marine glycolipids can be used as a potential component of drug delivery systems.
• Marine glycolipids have the potential for use in the field of food research because of their emulsification capacity and anti-adhesive activity.
• Marine glycolipids can be applied in the research of agriculture for their ability to inhibit certain phytopathogenic fungi, algal blooms, and insect larvae, thus promoting plant health.

Advantages

• We possess cutting-edge technology that enables us to analyze and characterize marine glycolipids with high accuracy and precision.
• Our research team consists of highly knowledgeable and experienced scientists who specialize in the field of glycoscience. They are proficient in extraction, purification, and characterization processes to deliver high-quality services and products.
• We offer comprehensive services, including production, purification, and characterization of marine glycolipids. Our clients will obtain all the necessary information and support they need for their projects at CD BioGlyco.

CD BioGlyco has many years of experience in the production of glycolipids from marine sources by employing advanced purification techniques. To obtain high-quality extracts, we conduct meticulous characterization and analyze the structural and functional properties of these unique molecules. Our services cater to various industries, providing clients with tailored solutions for their specific research and development needs. We would be delighted to hear from you. Please do not hesitate to contact us for any reason.