Fucoidan-based Tissue Engineering Development Service at CD BioGlyco
CD BioGlyco provides tissue engineering development services based on a variety of Marine Carbohydrates such as Hyaluronic acid, Chitin, fucoidan, etc. Fucoidan is a sulfated polysaccharide with antioxidant and hypoglycemic properties. Based on this, fucoidan is widely used in various medical and biological applications. To meet the needs of our clients in drug delivery, disease treatment, and others, we provide a one-stop fucoidan-based tissue engineering development service.
The fucoidan-based biomaterials we develop include but are not limited to the following:
Fucoidan-based nanoparticle development service
Fucoidan-based nanoparticles have potential applications in antimicrobials, magnetic resonance imaging contrast, and cancer therapy. We fabricate fucoidan-based nanoparticles by a variety of methods. Solvent evaporation, microwave, precipitation, emulsion, polyelectrolyte self-assembly, ultrasonication, and green synthesis methods are mastered. synthesis methods are well mastered.
Fucoidan-based hydrogel development service
We design the structure of fucoidan-based hydrogels according to client requirements. We carry out the design by studying the conformational relationship between crosslinking point density, crosslinking strength, monomer concentration and pore size, molding method, time, etc. Based on the gel fabrication methods developed so far, we choose ionic crosslinking, free radical polymerization crosslinking, and click chemistry for fabrication. Fucoidan has different biological roles based on its structural heterogeneity and molecular weight. We functionally Modify fucoidan based on fucoidan and product usage according to client requirements.
After fabricating fucoidan-based biomaterials, we will use a scanning electron microscope to observe the morphological structure of the fabricated biomaterials. Fourier transform infrared spectroscopy, mechanical, thermal properties, etc., are also Characterized.
Fig.1 The type of fucoidan-based tissue engineering we developed. (CD BioGlyco)
Publication Data
Technology: Photocrosslink
Journal: Journal of Biomaterials Science, Polymer Edition
IF: 3.682
Published: 2022
Results: In this study, fucoidan was functionalized with methacrylation (MFu) and further photocrosslinked to generate hydrogel particles. The MFu degree ranged between 2.78 and 6.50 as detected by NMR. The average diameter of the hydrogels ranged from 0.63 to 1.3 mm. Biological characterization of the hydrogel showed that the hydrogel could support the survival of pancreatic β-cells and maintain insulin release. Thus the fucoidan-based hydrogel has the potential to serve as a multifunctional carrier for the treatment of diabetes.
Fig.2 Scheme to illustrate the formation of the fucoidan-based hydrogel particles using visible light and superamphiphobic surface. (Reys, et al., 2022)
Applications
- Fucoidan-based biomaterials have promising applications in giving bone scaffolds for tissue engineering.
- Fucoidan-based hydrogels are loaded with hydrophobic drugs and have promising applications in drug delivery systems.
- Nanoparticles based on fucoidan are used for gastrointestinal antimicrobial and magnetic resonance imaging contrast agent development.
Advantages of Us
- We provide one-stop fucoidan-based tissue engineering development services from product design, optimization, and fabrication to testing.
- We are experienced in nanoparticle and hydrogel fabrication. Multiple fabrication methods are available.
- Through a variety of modification and optimization methods, we will fabricate products that exceed our client's expectations and have good performance.
At CD BioGlyco, our strengths are rich expertise, reasonable solutions, and an honest service attitude. We are always modifying and enhancing the breadth and width of our services. This is how we always do our best and achieve success. If you are interested in our fucoidan-based tissue engineering development services, please contact us for details such as fabrication methods. We will certainly address all your needs most responsibly.
References
- Reys, L.L.; et al. Fucoidan-based hydrogels particles as versatile carriers for diabetes treatment strategies. Journal of Biomaterials Science, Polymer Edition. 2022, 33(15): 1939-1954.
- Lin, J.; et al. Algal polysaccharides-based hydrogels: extraction, synthesis, characterization, and applications. Marine Drugs. 2022, 20(5): 306.
