Marine Carbohydrate-Polymer Conjugation Service

Marine Carbohydrate-Polymer Conjugation Service at CD BioGlyco

At CD BioGlyco, our goal is to facilitate and support clients in the biotechnology, biomedical fields, and others. Marine Carbohydrates have good biocompatibility, biodegradability, and a wide range of biological activities. Their complexes formed with natural polymers, etc., have good applications in drug delivery systems, tissue engineering, and so on. We provide a high-quality marine carbohydrate-polymer conjugation service.

Crustaceans such as crabs and shrimps are rich in chitin and chitosan, and they are ideal biopolymers. Our marine carbohydrate-polymer conjugation service is mainly based on chitin and chitosan.

Fig.1 Class of compounds that are conjugated to marine carbohydrates. (CD BioGlyco)

Our modification of chitin and chitosan mainly includes modification of the primary amino group of chitosan, etc., graft copolymerization, etc. We combine chitosan and chitin with catechol, caffeic acid, cyclodextrin, etc., or combine them after derivatization to form copolymers. It is found that the physical and chemical properties of modified chitosan and chitin are optimized and their biological activities are improved.

The protonated amino group in chitosan makes it a polycation. We form copolymers of chitosan with a variety of natural polymers, such as DNA, proteins, and lipids. We also form copolymers with synthetic anionic substances such as poly(acrylic acid) polymer. These copolymers have good applications in pharmaceuticals, cosmetics, water treatment, etc.

Publication Data

Technology: Free radical-mediated method

Journal: International Journal of Biological Macromolecules

IF: 3.671

Published: 2013

Results: In the present study, GA-grafted chitosan (GA-g-chitosan), a copolymer of gallic acid and chitosan, was synthesized by the free radical-mediated method. The optimum conditions for the synthesis of the copolymer, its structure, and its inhibitory activity on α-amylase and α-glucosidase. The optimal grafting conditions for synthesis were finally obtained by single-factor experiments. The results showed that the crystallinity and thermal stability of the copolymer were reduced compared to chitosan. It also showed strong α-glucosidase and α-amylase inhibitory activity. This polymer has the potential for diabetes drug development.

Fig.2 Mechanism of GA-g-chitosan synthesis. (Liu, et al., 2013)

Applications

• Conjugation of marine carbohydrates with other polymers plays a crucial role in the development of drug delivery systems. Chemical modification of carbohydrates, reaction with natural polymers, etc., improve the capacity and release efficacy of administered drugs.
• Conjugation of marine carbohydrates with other polymers plays a crucial role in the development of biotechnology such as chromatography.
• Conjugates formed by marine carbohydrates with other polymers are used in cosmetics, paper, textiles, and other fields.

Advantages of Us

• In addition to chemical modification, we polymerize marine carbohydrates with other biomolecules or synthetic polymers to enhance the properties of marine carbohydrates.
• With our vast experience in chemistry and glycobiology, we will excel in various conjugate synthesis challenges.
• We customize our exclusive and personalized marine carbohydrate-polymer conjugation services as per the client's requirements. All you need to do is tell us the purpose of your experiment.

CD BioGlyco has extensive experience in biopolymers and synthetic polymers. We are committed to solving any difficulties and challenges that our clients encounter in their research. Please feel free to contact us about the research direction of marine carbohydrate conjugation, polymer class, etc. We will do our best to provide the best service.