Deacetylated Chitin Adjuvant Development Service

Deacetylated Chitin Adjuvant Development Service at CD BioGlyco

CD BioGlyco has a state-of-the-art laboratory that is dedicated to Marine Carbohydrate-based Vaccine Development Service and Marine Carbohydrate-based Adjuvant Development Service. Our experienced scientists will communicate with you and customize deacetylated chitin adjuvant development solutions to your satisfaction.

• Deacetylated Chitin Immunoadjuvant Development
  We provide deacetylated chitin-based immune adjuvant development services for enhancing the immunogenicity of vaccines and improving the immune system response to vaccines. By binding or encapsulating with vaccine components, deacetylated chitin promotes the uptake, processing, and presentation of immunogens, thereby enhancing the immunization effect of the vaccine.
• Development of Deacetylated Chitin Controlled-release Adjuvant Development
  We develop controlled-release adjuvants based on deacetylated chitin by modulating its structure or complexing it with other substances. This results in the slow release of vaccine components, prolonging the duration of action of the vaccine, reducing the number of injections, and improving the stability and durability of the vaccine.
• Development of Deacetylated Chitin Cell Delivery Adjuvants
  We form a stable drug-carrying system by combining deacetylated chitin with other materials through chemical modification or physical cross-linking. Then we adjust the parameters of deacetylated chitin such as particle size, surface charge, morphology, etc., as well as optimize the delivery method of the drug-carrying system to improve the uptake efficiency of the drug-carrying system by the cells. The delivery efficiency is then improved by introducing appropriate targeting strategies so that the deacetylated chitin drug-carrying system can specifically bind to target cells. By adjusting the physical properties of the drug-carrying system or adding controlled-release materials, the slow and sustained release of the drug can be realized to prolong the action time of the drug in the cell and reduce the toxic side effects. Finally, the adjuvants are evaluated for cytotoxicity, hemocompatibility, biodegradability, and in vitro and in vivo.

Fig.1 Methods of deacetylation used in the development of deacetylated chitin adjuvants. (CD BioGlyco)

Publication Data

Technology: Static light scattering, flow cytometry, and ELISA antibody determination

Journal: Vaccine

IF: 5.5

Published: 2013

Results: This article focuses on the evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. It was found that the properties of chitosan (molecular weight, degree of deacetylation, particle size, viscosity, and impurities) affect its adjuvant activity. The use of different chitosan masses resulted in different levels of immune response, which could be attributed to the different properties of chitosan masses, such as molecular weight, deacetylation, particle size, and preparation techniques. This influences properties such as solubility and viscosity. Therefore, careful selection is needed when choosing chitosan mass in vaccine preparation. In addition, it was found that the solubility and deacetylation of chitosan affected the immune response, with lower deacetylation potentially leading to a stronger immune response. The article also mentions that impurities and contaminants in chitosan preparations have less of an effect on the immune response.

Fig.2 Deacetylated and acetylated glucosamine (chitosan monomers). (Scherließ, et al., 2013)

Applications

• Deacetylated chitin is used as an adjuvant in drug delivery systems to help improve the solubility, stability, and bioavailability of drugs.
• Deacetylated chitin is applied to support the field of tissue engineering and regenerative medicine, e.g., as a scaffolding material to repair fractures or soft tissue injuries.
• Deacetylated chitin is used in agriculture, for example as a plant protection agent, plant growth regulator, or soil remediation agent.

Advantages

• Deacetylated chitin is of natural origin with good biocompatibility, non-toxicity, and non-irritation to the human body, and is suitable for use in the pharmaceutical field.
• Deacetylated chitin is degraded by enzymes in living organisms and does not accumulate in the body.
• Deacetylated chitin can be modified and tailored to meet specific requirements, allowing for the development of different formulations and delivery systems.

At CD BioGlyco, our deacetylated chitin adjuvant development solutions are designed to be fast and efficient, enabling rapid progress in your projects. If you require assistance or would like more detailed information, please feel free to contact us directly.