Heparan Sulfate-based Biomaterial Engineering Development Service

Heparan Sulfate-based Biomaterial Engineering Development Service at CD BioGlyco

CD BioGlyco has extensive experience in the development of Biomaterials Based on Marine Carbohydrates. Heparan sulfate (HS) is a linear polysaccharide composed of repeating disaccharide units. As a polysaccharide present in the human body, biomaterials prepared from HS reduce the likelihood of adverse reactions in the human body when used. We provide one-stop engineering development services for HS-based biomaterials.

Fig.1 HS-based biomaterial engineering development service. (CD BioGlyco)

• Development of HS-based Scaffolds
  We mainly develop HS-based scaffolds, including hydrogels, films, and fibers. These scaffolds provide support structures for cell proliferation, migration, and attachment. At the same time, they mimic the extracellular matrix, creating an environment for cell adhesion and tissue formation.
  • HS-based hydrogel development
  • HS-based fiber development
  • HS-based film development
• Modification of Heparan Sulfate
  The repeating polysaccharides of HS are D-glucuronic acid, L-iduronic acid, and N-acetyl-D-glucosamine. It is less sulfated. Scaffolds prepared from pure HS may suffer from defects such as low mechanical strength and low degradation rate. We chemically modify HS to introduce specific bioactive molecules or functional groups. Targeted modification of scaffolds is achieved by chemical modification.
  Although HS occurs naturally in the human body, the safety assessment and biocompatibility of the developed HS-based scaffolds need to be verified experimentally. In addition to this, we test the mechanical strength, structure, porosity, water absorption, compressive stress, and others of the developed scaffolds.

Publication Data

Technology: Click chemistry

Journal: ACS applied materials & interfaces

IF: 9.5

Published: 2022

Results: In this study, a novel hydrogel was prepared by combining HS tetrasaccharide with neuronal cell adhesion-promoting peptides as raw material. The hydrogel was tested for its potential application in tissue engineering and the results showed that the hydrogel could increase the adhesion of human neural stem cells (hNSCs). It can also support neural cell activity and growth. The hydrogel can be used to regulate neuronal activity, fate, and growth factor signaling.

Fig.2 Chemical synthesis of HS-hydrogel components. (Latchoumane, et al., 2022)

Applications

• HS binds growth factors and controls their release. HS-based biomaterials are used to immobilize growth factors and achieve precise control of their release. Localized delivery of growth factors is achieved in this way.
• HS-based biomaterials are used to regulate various cellular processes, including directing cell behavior, regulating tissue development, and promoting cell migration and adhesion. This is important for tissue regeneration engineering.
• HS-based biomaterials are used to provide signals that regulate tissue development and direct cell behavior. With these biomaterials, researchers can control various cellular responses.
• HS has certain immunomodulatory properties. HS-based biomaterials are used to modulate inflammatory responses and immune responses, such as reducing unwanted immune responses or excessive inflammation during suppression of transplantation.

Highlights of Us

• We develop many types of HS-based scaffolds, including fibers, films, hydrogels, and others.
• We customize the properties of the scaffolds, such as mechanical strength, cell adhesion properties, degradation rate, etc., according to client requirements.
• We provide one-stop engineering development services for HS-based biomaterials. In addition to the design of biomaterials, we will carry out further R&D work, including refining synthesis techniques and improving scalability.

CD BioGlyco develops biomaterials that are closer to tissue engineering and regenerative medicine applications through continuous optimization. In addition to HS, we also prepare biomaterials using Ulvan, Cellulose, etc., as substrates. Please feel free to contact us to learn more about biomaterial engineering and development, and let us know your needs. We will do our best to provide you with biomaterials with high performance.