CD BioGlyco offers a range of marine-derived glycosides sourced from a wide variety of organisms such as algae, fungi, anthozoans, and echinoderms. For example, we employ a method where the dried body walls of marine invertebrates, specifically sea cucumbers, are meticulously ground into a fine powder. Subsequently, the powder is subjected to multiple extractions using aqueous ethanol until the ethanol reaches a decolorized state.
We use cellular and molecular biology techniques to study the biological activities and mechanisms of marine glycosides, Marine Carbohydrates, Marine Glycoproteins, Marine Lectins, and Marine Glycolipids. We possess the capacity to modify marine glycosides to cater to specialized needs. Furthermore, our diverse array of cell lines and animal models empowers us to investigate an expansive spectrum of physiological activities. Through these technologies, we conduct comprehensive analyses on the interplay between glycoside structure and its associated activity, enriching our understanding in this field.
Take the example of testing for anticancer activity.
- The anti-cancer potential of marine glycosides can be analyzed through the cultivation of different cancer cell lines in vitro. By growing these cells in a controlled environment and exposing them to different concentrations of marine glycosides, we will evaluate the efficacy of these compounds against various types of cancer.
- Furthermore, we have the capability to assess the potential anti-cancer effects of marine glycosides by conducting in vivo studies using mouse models with artificially induced tumors. This approach allows us to explore the efficacy and therapeutic potential of these compounds in a more complex and biologically relevant setting.
Floridoside is a compatible solute and is useful as an effective antifouling agent with therapeutic potential. We extract it from red algae by our advanced technologies.
D-Isofloridoside, a naturally occurring galactosylglycerol compound, is produced at CD BioGlyco. We also purify the crude extract to obtain pure glycoside.
CD BioGlyco uses the state-of-the-art platform to provide the production of aurantoside K which is a new antifungal tetramic acid glycoside.
CD BioGlyco produces aquastatin A from the marine-derived fungus Cosmospora sp. It is isolated using a variety of chromatographic methods, and its structure is primarily determined through the analysis of spectroscopic data.
CD BioGlyco provides a one-stop production service for stichoposide, including production, purification, and characterization.
At CD BioGlyco, we offer the production of frondoside which has been found to possess a wide range of anticancer effects. In addition, our advanced purification methods are utilized to obtain glycosides of exceptional purity and efficacy.
Luzonicoside, a particular steroid glycoside, is produced at CD BioGlyco. It is being studied due to its various biological activities.
Holothurin has drawn attention due to its potential anticancer properties, and we are distinguished for our efficient and effective production of this compound.
CD BioGlyco offers the production of marmoratoside that is antifungal triterpene glycoside, by various novel approaches.
CD BioGlyco provides the production of 17α-hydroxy impatienside, a class of antifungal triterpene glycosides, by using advanced technologies and innovative methods.
CD BioGlyco has implemented advanced technologies and rigorous quality control measures to produce 25-acetoxy bivittoside.
At CD BioGlyco, we provide a wide range of diverse and innovative methods for producing scabraside A. Our team employs cutting-edge technologies and sustainable practices to ensure high-quality production.
With our cutting-edge techniques, CD BioGlyco excels in producing echinoside A, a sulfonylated holostane tetrasaccharide with potent anticancer and antifungal activity, most efficiently and reliably.
CD BioGlyco offers a broad selection of varied and inventive approaches to produce sokodoside from the marine sponge.
Variegatuside is a new kind of triterpene glycoside and is produced at CD BioGlyco. This glycoside we produce is of high purity and high quality.
The production of pandaroside G at CD BioGlyco involves a diverse array of innovative methods. It has been studied for its antiprotozoal effects.
At CD BioGlyco, we employ advanced technologies and sustainable techniques to guarantee exceptional quality in the production of acanthifolioside.
CD BioGlyco possesses a professional research team that utilizes state-of-the-art methodologies and eco-friendly practices to ensure the production of high-quality carijoside A.
CD BioGlyco is committed to implementing cutting-edge technologies and sustainable techniques to maintain the superior standard of frodoside A production.
CD BioGlyco adopts diverse and innovative methods, as well as sustainable practices, to attain optimal quality in the process of cucumarioside production.
We possess diverse advanced Technologies for the Characterization of the extracted marine glycosides. These advanced methods enable us to gain comprehensive insights into the properties, composition, and structure of these valuable compounds.
Fig.1 Technologies for marine carbohydrate characterization at CD BioGlyco. (CD BioGlyco)
Publications
Technology: RP-C18 flash chromatography
Journal: Steroids
Published: 2009
IF: 2.7
Results: This study described the chemical analysis of a specimen from the marine sponge Pandaros acanthifolium, which was collected off the coast of Martinique at Canyon Rock. The order Poecilosclerida is known for its production of diverse guanidine alkaloids, and only acanthifolicin, a polyether carboxylic acid, has been previously isolated from P. acanthifolium. In this study, the authors reported the isolation of seven steroidal glycosides, named pandaroside A-D, as well as the methyl ester forms of pandarosides A, C, and D, which were found to be the major constituents of the P. acanthifolium sponge. The structures of these compounds were determined through extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) experiments, as well as high-resolution electrospray ionization mass spectrometry (HRESIMS) analyses. It was discovered that all of the newly identified compounds possess a rare 2-hydroxycyclopent-2-enone D-ring with a 14β configuration. The absolute configuration of the aglycon part of pandaroside A was determined by comparing the experimental data with the calculated circular dichroism spectra using Time-Dependent Density Functional Theory (TDDFT). Importantly, this study highlighted that P. acanthifolium is the first marine organism known to produce steroidal glycosides with such a unique aglycon nucleus.
Frequently Asked Questions
What is the structure of a marine glycoside?
The marine glycosides are composed of amphiphilic compounds, wherein a sugar is connected to another functional group via a glycosidic bond. The sugar moiety can range from a single unit (monosaccharide) to multiple units (oligosaccharide), while the aglycone or the attached functional group can vary and include terpenes, flavonoids, or other naturally occurring molecules.
What biological activities do marine glycosides have?
Marine glycosides exhibit a wide range of biological activities, which contribute to their significance in various fields. Some common biological activities associated with marine glycosides include anticancer activity, antimicrobial activity, anti-inflammatory activity, antiviral activity, and neuroprotective activity.
Applications
Advantages
- CD BioGlyco possesses a rich variety of marine organisms capable of yielding a diverse range of marine glycosides. Additionally, we have the expertise to cultivate microalgae cells internally to serve as a source for glycoside extraction.
- CD BioGlyco cultures various cancer cell lines that enable us to conduct comprehensive and accurate evaluations of the anti-cancer activity of marine glycosides. The results we offer are not only reliable but also rich in accuracy.
- In addition to in vitro studies, we also conduct in vivo evaluations utilizing animal models with induced tumors. These services will help clients assess the potential anti-cancer effects of marine glycosides in a more clinically relevant setting, providing the possibility for future translation into effective treatments.
CD BioGlyco possesses many experienced and knowledgeable researchers who are skilled at producing high-quality glycoside compounds from diverse marine organisms. By using advanced technology and established production processes, we complete production tasks with superior efficiency, ensuring that our operations are rich in diversity and variety. Additionally, our marine carbohydrate characterization service provides clients with a comprehensive analysis of the carbohydrate composition and structure in marine organisms. If you are interested in our Marine Biomolecule Production Service or have any inquiries, please don't hesitate to contact us. We would be excited to hear from you.
References
- Vasconcelos, A.A.; Pomin, V.H. Marine carbohydrate-based compounds with medicinal properties. Marine drugs. 2018, 16(7): 233.
- Cachet, N.; et al. Steroidal glycosides from the marine sponge Pandaros acanthifolium. Steroids. 2009, 74(9): 746-750.
