Porphyran-based Vaccine Development Service at CD BioGlyco
Porphyran has significant anticoagulant, antithrombotic, tumor-inhibitory, and immune-enhancing effects. Therefore, porphyran can be a good source of vaccine adjuvants due to its powerful immune-enhancing properties. At CD BioGlyco, we provide high-quality porphyran-based vaccine development services.
Extraction of Porphyran
The porphyran extraction method and purity affect its immunological activity. To minimize the error, we provide several methods to extract porphyran. For example, solvent extraction method (organic solvent), combined extraction method, and so on. Meanwhile, we take an orthogonal test to determine the best extraction process for porphyran.
Preparation of Porphyran Adjuvants and Development of Vaccines
At first, we use the in vivo and in vitro routes to investigate the role of porphyran in enhancing the cellular immune function of the organism at multiple levels in animal models, cells, and molecules. Secondly, we cremate porphyran with a certain volume ratio of antigen by grinding method, syringe mixing method, and ultrasonication. Next, we adjust the pH and collect the precipitate to obtain the adjuvant.
And finally, mixing and assembling adjuvants and antigens, stabilizers, emulsifiers, etc. to get the vaccine. In this process, we provide in vivo and in vitro experiments to test the immune activity of the prepared vaccine. For example, we offer pathogen attack experiments to evaluate the protective effect of this vaccine, as well as subtype assays and antigen neutralization site analysis.
Fig.1 Porphyran-based vaccine development services. (CD BioGlyco)
Applications
- Porphyran activates immune cells such as macrophages. The development of vaccines against porphyran can be used to explore the immune response mechanism and the secretion of immune-related molecules.
- The development of porphyran-based vaccines helps researchers to explore the biological activities of marine carbohydrates in depth.
- The development of porphyran-based vaccines could be used to probe marine carbohydrate-associated immune responses.
Advantages
- We offer custom research and development of marine carbohydrate vaccines based on our clients' requirements. Each program is developed by scientists in the field.
- We offer not only analysis of small quantities of products but also a large-scale professional custom vaccine vaccine development service.
- We have industry-leading vaccine development technology and our protocols are quality tested.
CD BioGlyco is committed to providing high-quality Marine Carbohydrate Vaccine Development Services to clients worldwide. Our services cover a large number of different types of marine carbohydrates, and we have a specialized team to track the research progress of new marine substances to meet our clients' needs in all aspects. If you would like to know more about glycobiology, please feel free to contact us.
References
- Sun, B.N.; et al. Polysaccharides as vaccine adjuvants. Vaccine. 2018, 36( 35): 5226-5234.
- Wan, X.H.; et al. Polysaccharides derived from Chinese medicinal herbs: A promising choice of vaccine adjuvants. Carbohydrate Polymers. 2022, 276: 118739.
