Ulvan-based Drug-Delivery Vehicle Development Service

Ulvan-based Drug-Delivery Vehicle Development Service at CD BioGlyco

Ulvan is a natural water-soluble complex anionic sulfated polysaccharide extracted from marine green algae. It has a unique chemical structure, mainly composed of sulfated rhamnose and glucuronic acid. The structure of functional groups (such as hydroxyl, carboxyl, and sulfate groups) makes them potential and valuable candidates for active biomaterials. CD BioGlyco has rich Marine Carbohydrate-based Drug-Delivery Vehicle Development experience and professional technology, and we provide diversified ulvan-based drug-delivery vehicle development service.

• Extraction and purification service: We deeply study and understand the chemical structure and biological activity of ulvan, a seaweed polysaccharide, and use advanced technology to extract and purify ulvan from green algae or use biosynthetic methods to obtain high-purity ulvan.
• Vehicle design and development service: We select appropriate vehicles for ulvan-based drug-delivery vehicle development according to the characteristics and needs of the target drug.
  • Liposomes: We prepare ulvan-based liposomes using various methods such as film hydration method, oil-water emulsion method, inverse microemulsion method, etc. These methods are prepared in organic solvents or inorganic solvents by direct aqueous methods.
  • Hydrogel: Ulvan has good viscosity and forms a gel through the gelation mechanism of calcium or boron ions. As a natural polymer of polysaccharides, ulvan is used to prepare hydrogels through physical methods of ionic cross-linking and phase change, as well as through chemical methods such as enzymatic cross-linking and free radical polymerization cross-linking.
  • Ulvan film: The structure of ulvan is rich in rhamnose, which reduces bacterial adhesion on the skin and has anti-inflammatory activity. Therefore, the medicated ulvan membrane has the potential to be used as a drug delivery device. CD BioGlyco provides cross-linked ulvan membrane development services. Ulvan is soluble in water, and the preparation of polymer films for use as wound dressings is carried out by solvent casting. We chemically cross-link ulvan with epoxides and mix the therapeutic with the polymer before casting. Once the solvent evaporates, a combined polymer-drug film is obtained.
• Drug encapsulation service: We effectively encapsulate target drugs in ulvan vehicles, for example, through physical encapsulation (such as adsorption or encapsulation), chemical cross-linking, or covalent modification. In addition, we improve the stability of the vehicle and drug release efficiency through surface modification or material modification.
• Characterization and evaluation service: We provide comprehensive characterization and evaluation for the developed ulvan-based drug delivery vehicles, including particle size analysis, drug loading determination, stability studies, drug release kinetics, and other experiments.

Fig.1 Ulvan-based drug-delivery vehicle development service. (CD BioGlyco)

Publication

Technology: Thin film hydration technology

Journal: Journal of Functional Biomaterials

IF: 4.901

Published: 2022

Results: The authors prepared liposomes containing ulvan through thin film hydration technology, embedded the antibacterial drug fusidic acid in the liposomes, and developed an ulvan-based antibacterial drug delivery platform. The authors conducted systematic physical and chemical characterization and antibacterial activity evaluation of the prepared liposome preparations. The results showed that the developed nanoscale liposomes had a highly charged surface, which was conducive to drug encapsulation and exhibited good antibacterial activity.

Fig.2 Preparation process of liposomes containing ulvan. (Tziveleka, et al., 2022)

Applications

• Skin disease: Encapsulating anti-inflammatory drugs and antibacterial drugs in ulvan achieves the gradual release of drugs, reduces inflammatory reactions, and promotes skin healing and recovery.
• Anti-infectious: The use of ulvan vectors to deliver antibacterial drugs effectively deals with infectious diseases, such as bacterial and fungal infections. As a vehicle, ulvan is highly stable and biocompatible, which provides sustained drug release and enhances anti-infective effects.
• Tissue trauma: Loading wound repair drugs into ulvan vehicles promotes wound healing and tissue regeneration. This vehicle provides sustained drug release, support, and protection to damaged areas, promoting the growth of new tissue and the repair process.

Advantages

• CD BioGlyco has advanced experience in drug delivery system design, including expertise in vehicle material selection, controlled release mechanism, stability improvement, etc.
• CD BioGlyco prepares and characterizes various forms of ulvan-based drug delivery vehicles, including nanoparticles, microparticles, etc., to meet different drug delivery needs.
• CD BioGlyco has established an efficient R&D process to ensure on-time delivery of high-quality ulvan-based drug delivery vehicles.

CD BioGlyco has experience in developing ulvan-based drug delivery vehicles in different application fields, such as anti-infection, skin diseases, etc. We provide personalized ulvan-based drug delivery vehicle solutions according to the client's specific needs and application scenarios. Please feel free to contact us if you are interested in our vehicle development service.