Heparin-based Drug-Delivery Vehicle Development Service

Heparin is a negatively charged polysaccharide with a variety of biological activities. In particular, it has inherent solubility and biocompatibility, well suited as a Carbohydrate-based Drug-Delivery Vehicle. Heparin-based drug-delivery vehicle provides better pharmacokinetics and drug performance properties. CD BioGlyco has accumulated rich experience in developing a heparin-based drug delivery system that can be adsorbed and localized to specific tissues or organs through appropriate ligands.

Heparin-based Drug-Delivery Vehicle Development Service at CD BioGlyco

• Synthesis of Heparin-based Drug-Delivery Vehicle: Through vehicle synthesis by poly and co-aggregation and self-assembly, the heparin is efficiently fixed on the surface of the carrier such as magnetic beads. Furthermore, we provide carbon dots (CDs)-heparin drug-delivery vehicle development service. CDs-Heparin nanoparticles by forming an amide group between CDs and Heparin. In addition, the synthesized vector is purified and dialyzed to facilitate the next service. Our development team pays special attention to the control of the response process. For the targets, we provide the following identification and characterization services:

• Drug Loading Efficiency and In Vitro Release Service: The stimulation-response drug release efficiency of the drug delivery system is further evaluated. We simulate a variety of different conditions (pH, hyaluronidase) to evaluate the release effect. Our investigators detect the compatibility between biomaterials and blood based on hemolysis service. We provide in vitro cytotoxicity detection services via MTT. Detection of cell activity and mobility based on in vitro scratch assay services. Furthermore, we provide cell imaging and drug tracking capability analysis and detection services.

Fig.1 Flowchart of heparin-based drug-delivery vehicle development services. (CD BioGlyco)

Publication

Technology: FTIR, Nuclear magnetic resonance, TEM

Journal: RSC Advances

Published: 2017

IF: 4.036

Results: In this study, a heparin-based drug-delivery vehicle was designed and synthesized by surface modification of heparin using adriamycin hydrochloride (DOX) as a drug model. Amino-enriched CDs were prepared by hydrothermal polymerization, and the CDs were immobilized on the surface of heparin by chemical bonding. All intermediates and final products were characterized using NMR and FTIR spectroscopy. The surface amino groups provided the CDs with an extremely high drug-carrying capacity (28.45 wt%). Subsequently, the delivery efficiency was tested by in vitro drug release, cytotoxicity assay, and in vivo antitumor activity assay. The results showed that the prepared drug system inhibited the proliferation of tumor cells and could achieve an effective therapeutic effect.

Fig.2 Factorial analysis results. (Zhang, et al., 2017)

Applications

• The heparin-based drug-delivery vehicle effectively prevents coagulation.
• The heparin-based drug-delivery vehicle is promising in the field of cancer therapy and visual drug tracking.
• The heparin-based drug-delivery vehicle targets cancer cells and effectively inhibits the growth and migration of cancer cells while reducing the adverse side effects on normal cells.

Advantages of Us

• Our researchers have extensive experience in drug-delivery vehicle development and provide our clients with drug-delivery vehicle development services for high drug bioavailability, strong targeting, low side effects, and positive therapeutic effects.
• Our company attaches great importance to service quality. Each step in the synthetic service is tightly controlled.

CD BioGlyco has many years of experience in drug-delivery vehicle development. Our technical team rationally plans the project according to the drug characteristics and release location, and rapidly promotes the project development with high efficiency. Based on marine carbohydrate, we also provide high-quality Vaccine Development, Adjuvant Development, Biomarker Development, Mimetic Development, and Biomaterial Engineering Development services. Please feel free to contact us.