Glycosaminoglycan-based Tissue Scaffold Development Service

Glycosaminoglycan-based Tissue Scaffold Development Service at CD BioGlyco

At CD BioGlyco, our Marine Carbohydrate-based Biomaterials Engineering Development Services cover a diverse range of different types, such as glycosaminoglycans (GAGs), Hyaluronic Acid, Alginate, etc. GAGs are a class of viscous polysaccharides that belong to a common group of natural biomolecules. GAGs consist of repeating disaccharide units. It is a biologically active macromolecule with a wide range of clinical applications in anticoagulation, anti-inflammation, anti-tumor, etc. It also effectively promotes cell proliferation and adhesion and has more development and application in the field of tissue engineering. We provide many types of GAG-based tissue scaffold development services. Tissue scaffold development includes but is not limited to the following:

GAG-based Hydrogel Development Service

GAG-based hydrogels are used for cell-responsive remodeling, skin and corneal wound healing, and more. Our methods for preparing GAG-based hydrogels include two: physical cross-linking, and chemical cross-linking. We make GAG suitable for various research applications through simple Modifications.

GAG-based Cryogel Development Service

Cryogels are a class of macroporous interconnected hydrogels formed by polymerization at subzero temperatures. We prepare GAG-based cryogels by physical cross-linking or chemical cross-linking. In the chemical cross-linking method, we use several cross-linking agents, including low molecular cross-linkers (glutaraldehyde, bis-epoxides, divinyl sulfone, etc.), oligo-bifunctional cross-linkers, and others. We optimize the biophysical properties of the cryogel by chemical modification to ensure the best results.

Fig.1 Types of GAG-based tissue scaffold development. (CD BioGlyco)

We also Characterize the physical and chemical properties of the prepared hydrogels, etc., including rheological characterization, cryo-scanning electron microscopy characterization, etc.

Publication Data

Technology: Click chemistry

Journal: Bioactive Materials

IF: 16.874

Published: 2021

Results: In this study, a GAG hydrogel system was designed and synthesized for accelerated healing of skeletal muscle injuries. The system consisted of thiolated chondroitin sulfate and thiolated hyaluronic acid with poly(ethylene glycol) diacrylate. The biophysical properties of this hydrogel were optimized by fine-tuning the degree of thiol group substitution. In vivo experiments in mice showed that the hydrogel promoted the formation of newborn muscle fibers, innervation, and so on. This study demonstrated the promising application of GAG hydrogel as a matrix for regenerative engineering.

Fig.2. Schematic representation of hydrogel synthesis and formation. (Narayanan, et al., 2021)

Applications

• GAG-based tissue scaffolds have an important role in studies to promote wound healing in damaged, vascularized tissues.
• GAG-based tissue scaffolds are ideal materials for tissue engineering scaffolds. It has wide application potential in the field of drug delivery for encapsulation and slow release of drugs.
• The developed GAG-based tissue scaffolds are used in studies such as cartilage and bone repair.

Advantages of Us

• We have advanced instrumentation to characterize the structure and physical properties of the prepared GAG-based biomaterials.
• We develop GAG-based hydrogels, cryogels, and other development services. All of our client's requests are accomplished.
• We provide a one-stop service for the development of GAG-based biomaterials. Clients only need to tell us the purpose, and we will complete all the steps of biomaterial design, preparation, and testing.

CD BioGlyco has proprietary processes and high technology in the preparation of biomaterials such as hydrogels. Our goal is to provide high-quality biomaterial design and custom preparation services to various researchers. Please feel free to contact us for more information about GAG hydrogel design, preparation, and more if you are interested in our GAG-based bio-biomaterials engineering and development services.