Porphyran-based Drug-Delivery Vehicle Development Service

Porphyran-based Drug-Delivery Vehicle Development Service at CD BioGlyco

Various types of sugar compounds exist in the marine environment, these marine sugars have special structures and biological activities and are used as potential candidates for drug delivery vehicles. CD BioGlyco has a leading position in the field of marine sugar research, and our professional technical teams provide clients with various types of Marine Carbohydrate-based Drug-Delivery Vehicle Development services.

Porphyran is a polysaccharide extracted from red algae, which is a sulfated linear polysaccharide composed of D-galactose and L-galactose in different orders and connections. We provide professional porphyran-based drug-delivery vehicle development service, the vehicles we provide include but are not limited to the following types.

• Nanoparticles: We modify porphyran into the form of nanoparticles. A common method is to use suitable nanomaterials (such as polymers, metal oxides, etc.) to interact with porphyran to form nanoparticles. These nanoparticles alter drug release rates and stability by controlling particle size and surface properties.
• Hydrogel: We assemble porphyran with other highly biocompatible materials such as gelatin or sodium alginate to form a hydrogel structure, which is used for topical drug delivery or wound dressings to promote wound healing and sustained release of drugs.
• Liposomes: We assemble porphyran and phospholipid-like substances into a lipid bilayer structure to form liposomes, which are used for drug encapsulation and targeted delivery.
• Cellulose matrix: We incorporate porphyran into a cellulose matrix to form cellulose nanoparticles or cellulose films, which are used for administration routes such as oral, injection, or dermal application. Porphyran-based drug delivery vehicles are applied to improve the bioavailability, stability, and drug delivery. The development of porphyran-based drug delivery vehicles generally requires the following steps.
• Extraction and purification: We extract porphyran from suitable sources such as red algae and undergo appropriate purification processes to obtain high-purity porphyran.
• Vehicle design and preparation: Based on the characteristics and drug delivery requirements of the target drug, we design the structure and composition of a porphyran-based drug delivery vehicle and perform efficient vehicle preparation.
• Drug encapsulation: We interact target drug with the vehicle and use physical or chemical methods to encapsulate the drug into vehicles to form a drug-vehicle complex.
• Performance characterization: We characterize the physical properties of the prepared vehicle in terms of particle size distribution, drug encapsulation efficiency, stability, and release kinetics to evaluate its performance and effect.
• Targeted modification: In addition, according to research needs, we perform targeted modification on the vehicle, such as introducing ligands targeting specific receptors or cells through covalent coupling or physical adsorption, thereby improving the targeting of the vehicle.
• Vehicle evaluation: We evaluate the stability, drug release performance, biocompatibility, and safety of the vehicle through in vitro and in vivo experiments to better achieve the drug delivery effect of the vehicle.

Fig.1 Porphyran-based drug-delivery vehicle development service. (CD BioGlyco)

Publication

Technology: Complex coacervation

Journal: Journal of Drug Delivery Science and Technology

IF: 5.062

Published: 2021

Results: The author prepared resveratrol (RES)-loaded nanoparticles (OPR) through a complex condensation method using Porphyra haitanensis polysaccharide (PHP) and ovalbumin (OVA) as encapsulation materials. The properties of the prepared vehicles were characterized, and their stability and RES release in vivo were studied. The results showed that compared with OVA-RES nanoparticles (OR), RES in OPR was released faster in the intestine and slower in gastric digestion. Moreover, OPR was found to inhibit the growth of two tumor cell lines, indicating that OPR nanoparticles delivered RES in biological systems.

Fig.2 Results of simulated OPR in vitro release. (Xu, et al., 2021)

Applications

• Disease research: Porphyran vehicles are used to deliver anti-inflammatory drugs, antibacterial drugs, anti-cancer drugs, and other disease drugs to achieve targeted delivery of drugs.
• Tissue engineering research: Porphyran vehicles are used to support cell growth and tissue repair, which act as a drug vehicle to promote tissue regeneration and repair processes, such as bone regeneration, soft tissue repair, etc.
• Contrast agent delivery: Porphyran vehicles deliver contrast agents commonly used in medical imaging, such as magnetic resonance imaging (MRI) contrast agents and computed tomography (CT) contrast agents.

Advantages

• CD BioGlyco has unique drug delivery technologies that effectively combine porphyran with drugs and achieve functions such as controlled release and targeted delivery.
• CD BioGlyco has advanced vehicle development means. We precisely control the size, shape, and stability of porphyran vehicles to achieve the development of custom drug delivery vehicles.
• CD BioGlyco has comprehensive professional experience in drug development and manufacturing, that apply porphyran-based drug-delivery vehicle to the industrial preparation and commercial production of various drugs.

CD BioGlyco has a leading position in the field of porphyrin development. Our professional technical team will provide clients with cutting-edge porphyran-based drug delivery vehicle development and Vaccine Development services. Please feel free to contact us if you are interested in our services.