Marine Glycan Characterization Service

Marine Glycan Characterization Service at CD BioGlyco

At CD BioGlyco, we understand that every client has different needs and goals, which is why we offer customized solutions to help them achieve success. Our Marine Glycomics Service is highly sought after, attracting significant interest from our clients. Whether our clients require assistance with Marine Glycan Release Service, Separation and Purification Service, Derivatization Service, or characterization service, our team of experts is dedicated to providing the highest quality service and support.

• Structural Characterization
  We determine information about the chemical structure and linkages of marine sugar molecules by using techniques such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and infrared spectroscopy (FTIR). We use these techniques to non-destructively analyze and determine your marine sugar molecules to provide you with more accurate results.
• Monosaccharide Composition Analysis
  We break down marine sugars into monosaccharides by acid hydrolysis or enzymatic hydrolysis, etc. Then we use chromatographic techniques such as high-performance liquid chromatography (HPLC) and gas chromatography (GC) to separate and quantify individual monosaccharides to understand their monosaccharide composition.
• Optical and Thermal Property Analysis
  We help you understand the potential of marine sugars for applications in optical sensors or fluorescent probes by determining the absorbance, fluorescence properties, and other properties of the compounds through spectroscopic analysis techniques. Meanwhile, we provide the determination of the melting point and thermal stability of marine sugars through thermal analysis techniques such as differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA).

Fig.1 Marine glycan characterization. (CD BioGlyco)

Publication Data

Technology: Matrix-assisted laser desorption/ionization MS (MALDI-MS) and electrospray ionization MS (ESI-MS)

Journal: Marine Drugs

IF: 5.4

Published: 2014

Results: This paper details the progress made in the application of MS in the structural analysis of marine oligosaccharides. By MS, information such as molecular mass, degree of polymerization, composition, sequence, linkage position, and substituent distribution of marine oligosaccharides can be analyzed. For neutral or low-sulfated oligosaccharides, they can be analyzed directly by ESI or MALDI-MS. For highly sulfated oligosaccharides, they can be analyzed by the stabilized natriuretic form in ESI-MS or deduced by derivatization methods in MALDI-MS. MS techniques, particularly through the multi-step strategy of ESI tandem MS, are employed for the identification of highly sulfated oligosaccharides and the determination of their sequence and sulfation sites. In addition, MS is used to determine the location of sulfation and epimerization by the abundance of characteristic ions. In conclusion, MS has important applications in the structural analysis of marine oligosaccharides.

Applications

• Marine glycans are widely used in drug discovery and development because of their various biological activities, such as antioxidant, anti-inflammatory, and anti-tumor effects.
• Marine glycans have diverse structures and bioactivities and are used as biomaterials for detection, separation, and purification.
• Marine glycans are used to produce biodegradable plastics, bio-based materials, and other environmentally friendly materials, which help to reduce the environmental pollution caused by traditional plastics.

Fig.2 Bioactivities and application of marine oligosaccharides. (Luan, et al., 2023)

Highlights

• With advanced analytical techniques and equipment, we perform comprehensive structural characterization and analysis of marine glycans, thus providing accurate data support to our clients.
• We offer customized marine glycan characterization services as well as customized testing and reporting for specific applications based on client needs.
• Marine glycans have structural and functional properties that are unique to those of terrestrial sources, so our marine glycan characterization service helps clients gain insight into and capitalize on this uniqueness, providing new perspectives and opportunities for their research and development.

CD BioGlyco has advanced skills to provide different characterization methods for your marine glycans and we use existing characterization protocols or develop new routes to meet clients' needs for respective projects. Please feel free to contact us if you have any questions regarding our services.