Chitin-based Tissue Engineering Development Service at CD BioGlyco
CD BioGlyco is equipped with a specialized research team for the Engineering Development of Biomaterials Based on Marine Carbohydrates (Chitosan, chitin, Carrageenan, Fucoidan, etc). Chitin exists in three isomeric forms, consisting of N-acetyl-D-glucose-2-amine units. It is a basic structural component of many marine organisms such as shrimp, crabs, lobster, and others. Chitin is found to be an ideal candidate for tissue engineering, drug delivery, wound dressings, and more. We offer services for the development of chitin biomaterials based on a wide range of applications.
Chitin-based Tissue Engineering Development Service
Chitin is found to accelerate drug delivery, improve bacteriostatic properties, and enhance immune activity. Therefore, it is used to develop scaffolds for various biomedical applications. We mainly use chitin to fabricate porous sponges, hydrogels, and fiber scaffolds. Chitin scaffolds have poor elasticity and physical properties which limit their application in tissue engineering. Blending chitin with other biopolymers improves the mechanical properties of the scaffolds. We modify chitin in a variety of ways. In addition to its Modification, it is also blended with other biopolymers to develop scaffolds with good properties.
Porous scaffolds
A homogeneous porous structure promotes organ vascularization, bone regeneration, and tissue growth. We fabricate ideal chitin-based porous scaffolds by optimizing various influencing factors. Such scaffolds provide excellent structural support for cells and also mimic the extracellular matrix environment for nutrient delivery.
Hydrogels
Hydrogels are formed mainly through non-covalent or covalent crosslinking. Chitin-based hydrogels have good swelling, mechanical properties, and hemostatic activity. We have a variety of crosslinking methods to fabricate hydrogels, including click chemistry, ionic crosslinking, and others.
Fibrous scaffolds
Fibrous biomaterials are used as extracellular matrix for tissue engineering applications. Fibrous chitin structures are superior in biomedicine based on their antimicrobial and wound-healing properties. We develop nanofibers and microfibers that are used for bone tissue, cartilage tissue, and soft tissue engineering as per client requirements.
Technology for The Preparation of Chitin-based Scaffolds
We fabricate chitin-based scaffolds through various techniques, including 3D printing, freeze-drying, sol-gel freeze-drying, electrospinning, etc.
Fig.1 Process for the development of chitin-based tissue engineering. (CD BioGlyco)
Publication Data
Technology: Click chemistry
Journal: Carbohydrate Polymers
IF: 11.2
Published: 2023
Results: In this study, an injectable hydrogel based on chitin was developed. It contains an aldehyde group of oxidized dextran and an amino group of quaternized β-chitin (QC). The physicochemical properties of this hydrogel (QC hydrogel) were examined, and the results showed that the introduction of the aldehyde group and quaternization treatment enhanced the bioactivity and water solubility of chitin. The hydrogel prepared from this material has shear-thinning properties and self-repairing ability, which can be used for physical support and tissue repair.
Fig.2 Preparation and characterization of QC hydrogel. (Yang, et al., 2023)
Applications
- Polymer scaffolds fabricated from chitin are used for gene or drug delivery.
- Tissue scaffolds fabricated from chitin are used in bone tissue engineering to enhance the proliferation and viability of osteoblasts.
- Tissue scaffolds fabricated from chitin are ideal for wound dressings to allow for more effective cell adhesion and proliferation.
Advantages of Us
- We develop a wide range of chitin-based biomaterials. The different research needs of our clients are met.
- During the development process, we consider the effect of chitin ratio, degree of deacetylation, and others on the biomaterial. Our goal is to fabricate bioscaffolds with the best results.
- Our chitin-based tissue engineering development services are available to a variety of clients focused on bone tissue engineering, cartilage tissue engineering, tissue regeneration, and other research.
At CD BioGlyco, our team has experience in almost all solutions involving the development of polysaccharide-based bioscaffolds. If you need to develop chitin-based hydrogels, fibers, and others, please feel free to contact us with your needs. We will support you through the entire process of bioscaffold design, preparation, and testing.
References
- Yang, L.; et al. Chitin-based hydrogel loaded with bfgf and sdf-1 for inducing endogenous mesenchymal stem cells homing to improve stress urinary incontinence. Carbohydrate Polymers. 2023, 319: 121144.
- From Wikipedia (https://en.wikipedia.org/wiki/Chitin#/media/File:Haworth_projection_of_chitin.svg)
