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At CD BioGlyco, our goal is to provide products with good performance that exceed client expectations. Marine carbohydrates are widely used in nanobiotechnology, biomedicine, and other fields due to their biodegradability, biocompatibility, ease of modification, abundant sources, etc. We provide biomaterials engineering development services based on different marine carbohydrates.
Fig.1 The structures and biological activities of several marine carbohydrates. (Chen, et al., 2020)
Biomaterial Development
The types of marine carbohydrate-based biomaterials that are developed include, but are not limited to, the following:
Marine carbohydrates with specific structures and bioactivities are prepared into various nanomaterials by green methods. We provide high-quality development services for marine carbohydrate-based nanomaterials. Surface modification of marine carbohydrates greatly enhances their applications in the field of nanomaterials. We also perform selective modification of marine carbohydrates, such as acetylation, sulfation, etc. The modified marine carbohydrates are easy to prepare and decorate nanoparticles. Our goal is to develop nanomaterials with good physical and chemical properties and biocompatibility. We will design them according to the different needs of biological applications for targeted cancer therapy, photothermal therapy, sensing, etc.
Hydrogel design is an important step in developing systems with new structures and properties. According to client requirements, we design the composition, chemical structure, rheological properties, biodegradability, etc., of the hydrogel. Creating crosslinks within the structure is a key factor in hydrogel preparation. We use a variety of physical and chemical methods for cross-linking. Physical interaction processes include association, aggregation, crystallization, etc. Chemical hydrogels are prepared by chemical reactions, the addition of cross-linking agents, etc.
In addition to these, we offer development services for marine carbohydrate-based films, tissue engineering scaffolds, and more.
Modification of Marine Carbohydrates
Marine carbohydrates have a variety of functional groups, such as hydroxyl, carboxyl, amino, ester, sulfate, etc., which are functionalized through chemical modification and other means. We have various types of chemical modifications for marine carbohydrates. Sulfation, acetylation, carboxylation, etc. are achieved.
Fig.2 Marine carbohydrate-based biomaterial engineering development service. (CD BioGlyco)
Different carbohydrates have different structures and properties. We further subdivide our biomaterials engineering development services into the following categories to better meet the research needs of our clients in different fields such as biomedicine.
Glycosaminoglycan is a biologically active and abundantly sourced natural macromolecule. CD BioGlyco offers several types of glycosaminoglycan-based tissue scaffold development services.
Hyaluronic acid has a wide range of applications in hydrogel development due to its unique rheological properties and ease of modification. CD BioGlyco provides high-quality hyaluronic acid-based hydrogel development services.
Alginate has been widely used in the development of hydrogel scaffolds for tissue engineering. CD BioGlyco develops reliable alginate-based hydrogel products.
The use of chitosan in bone regeneration has been widely studied. CD BioGlyco develops chitosan-based tissue scaffolds with different modifications for bone repair and other applications.
Chitin-based scaffolds have been shown to support chondrocyte attachment and extracellular matrix preparation in vitro. CD BioGlyco offers a modified chitin-based tissue engineering development service.
Carrageenan has been used to develop hydrogels that can be used for tissue engineering, drug delivery, etc. CD BioGlyco offers a carrageenan-based tissue scaffold development service based on its extensive experience in tissue scaffold development.
Fucoidan has good biological activities such as antioxidant, anti-inflammatory, etc. CD BioGlyco provides a one-stop fucoidan-based tissue engineering development service.
CD BioGlyco provides extracellular polysaccharide-based tissue scaffold development services from design and preparation to testing.
CD BioGlyco provides ulvan-based tissue engineering development services for biomedical, regenerative repair applications, etc. We develop biomaterials such as 3D porous scaffolds and hydrogels.
Cellulose is an ideal candidate for biomaterial preparation. CD BioGlyco offers cellulose-based biomaterial engineering development services for bone tissue engineering, etc.
Hemicellulose is a renewable resource. CD BioGlyco provides hemicellulose-based film properties, including mechanical properties, biocompatibility, and more, through a variety of chemical and physical modifications.
Xylan is abundantly available and is an ideal polysaccharide that can be used in the preparation of biomaterials. CD BioGlyco provides xylan-based tissue engineering development services including hydrogels, etc.
Heparan sulfate is an attractive substance for preparing biomaterials. CD BioGlyco provides a high-quality heparan sulfate-based biomaterial engineering development service.
CD BioGlyco provides a one-stop marine peptidoglycan-based biomaterial engineering development service including design, preparation, and determination of physical and chemical properties.
CD BioGlyco aims to support drug delivery and biomedical research through the development of high-quality marine capsular polysaccharide-based biomaterials.
Technology: Click chemistry reaction
Journal: Communications Biology
IF: 6.548
Published: 2022
Results: In this study, hydrogel and macroporous cryogel materials based on synthetic glycosaminoglycans were synthesized. The results showed that aqueous human umbilical vein endothelial cells cultured on this hydrogel differentiated into tubular structures. When the cryogel was implanted into a subcutaneous mouse model, the results showed a decrease in immune response and an increase in blood vessel formation. This study demonstrated that both scaffolds can specifically release desired growth factors in vitro and in vivo. Also, this study provides data support for the synthesis of functionalized macroporous scaffolds.
Fig.3 Schematic of the generation of functionalized hydrogels. (Söderlund, et al., 2022)
CD BioGlyco is a leading supplier in the field of glycobiology. We are committed to providing various solutions and services for research, biotechnology development, and preparation related to marine carbohydrates. Please feel free to
for more detailed information on tissue engineering development and more. We take responsibility for every project to the end.References