Xylan-based Tissue Engineering Development Service

Xylan-based Tissue Engineering Development Service at CD BioGlyco

CD BioGlyco offers a variety of Biomaterial Development Services Based on Marine Carbohydrates such as Cellulose, Hemicellulose, xylan, etc. Xylan is mainly obtained from plants and algae. It is found to be widely available and is an ideal raw material for the preparation of biomaterials that are used for tissue engineering. To meet the research needs of our clients for wound healing, drug delivery, etc., we offer many types of xylan-based tissue engineering development services.

Xylan-based Hydrogel Development Service

Hydrogels are widely used in environmental, industrial, and biomaterial fields. We prepare hydrogels by covalent cross-linking or physical cross-linking. Xylan is one of the most abundant polysaccharides containing a backbone of anhydrous-D-xylose units linked by β-(1→4) glycosidic bonds. This backbone may occasionally have some side chains such as neutral sugar units, α-D-glucuronic acid, etc., attached. To improve the properties of the hydrogel, we Modify the xylan or prepare the xylan by mixing it with other compounds, such as acrylic acid, chitosan, and the like. After mixing xylan with other substances, hydrogels for tissue engineering are finally prepared by methods such as freeze casting. In the process of preparation, we consider the swelling rate, mechanical properties, compatibility for cell and tissue growth, etc.

Xylan-based Film Development Service

It is found that polymer films are used to create effective drug delivery systems. Due to xylan's inherent low molecular weight and low water solubility, the performance of films produced with it as a material is unstable. We prepare films by mixing xylan with other biomolecules or isomerizing and modifying xylan.

In addition to hydrogels and films, xylan is also used to prepare nanoparticles and microparticles. The final prepared materials are evaluated for their structure, morphology, and properties by wide-angle X-ray diffraction (WXRD), thermogravimetric analysis (TGA), dynamic mechanical analysis (DMA), etc. Our ultimate goal is to provide our clients with ideal xylan-based biomaterials with extremely high performance.

Fig.1 Process of xylan-based tissue engineering development. (CD BioGlyco)

Publication Data

Technology: Chemical and physical crosslinking

Journal: Carbohydrate Polymers

IF: 11.2

Published: 2022

Results: In this study, a simple and green method was used to prepare hydrogels using linear xylan and a PVA network chemically crosslinked with innocuous sodium trimetaphosphate (STMP). The xylan and others selected for this study have proper water solubility and molecular weight. To verify the feasibility of this method, the prepared hydrogels were characterized in this study. The results showed that the gels had excellent compressive resilience, compressive properties, recovery ability, and biocompatibility and were non-toxic. The hydrogel prepared in this study has good application prospects.

Fig.2 (a) Schematic illustration of the preparation of the hydrogels and (b) proposed mechanism of crosslinking reaction between PVA and STMP. (Han, et al., 2022)

Applications

• Xylan-based biomaterials are important in the study of contact lenses, biosensor membranes, etc.
• The developed xylan-based biomaterials are used in the manufacture of liquid absorbents.
• The developed xylan-based biomaterials are used to replace cartilage and other materials that require compressive strength.

Advantages of Us

• We have many types of solutions for analyzing the structure, size, and shape of hydrogels, films, and nanoparticles.
• When designing material for a customer's specific application, we optimize its size distribution, surface properties, dispersion, etc. to ensure optimal results.
• With our extensive experience in chemical synthesis, various modifications to xylan are realized.

CD BioGlyco has been refining the technology and experimental procedures associated with marine carbohydrate research for many years. Clients choose us not only for our high-quality solutions but also for our collaborative philosophy, responsible attitude, and expertise. Please feel free to contact us for more information on xylan modification, biomaterial preparation process, etc.