Alginate-based Drug-Delivery Vehicle Development Service

Alginate-based Drug-Delivery Vehicle Development Service at CD BioGlyco

Alginate is mainly isolated from the cell wall and intracellular space of seaweed, such as kelp and Ascophyllum nodosum. As an acidic marine colloidal polysaccharide, it is both a biopolymer and a polyelectrolyte with the characteristics of non-toxicity, biocompatibility, biodegradability, chemical versatility, and cross-linking ability. Alginate is a suitable material for drug delivery systems because it is easily modified into derivatives with different structures and functions. CD BioGlyco has mature Marine Carbohydrate-based Drug-Delivery Vehicle Development means, and we provide diversified alginate-based drug-delivery vehicle development services.

• Alginate-based nanogel vehicle development service: Nanogel is a three-dimensional cross-linked polymer network composed of hydrogel particle entities with nanometer-sized spaces, which has a large encapsulation cavity, swelling ability, and easily delivers drugs to various target cells. We offer a variety of preparation methods for alginate hydrogels.
  • Ionic cross-linking: We use divalent cations such as Ca²⁺, Mg²⁺, etc. as ionic cross-linking agents to prepare alginate hydrogels.
  • Covalent cross-linking: We covalently cross-link carboxyl groups in two different alginate branches with cross-linking molecules with primary diamines to generate alginate gels.
  • Phase change: A thermally responsive phase change occurs when the temperature enhances above the lower critical solution temperature (LCST). We incorporate poly(N-isopropyl acrylamide) (PNIPAM) into the backbone of alginate, and the resulting copolymer achieves thermoresponsive properties.
  • Free radical polymerization: We modify the alginate chains with functional groups (methacrylates) and then perform free radical polymerization with a photoinitiator and Ultraviolet (UV) irradiation.
  • Click chemistry: We used the principle of click chemistry to perform a reaction on oxidized alginate groups and amino gelatin groups to develop alginate-gelatin composite hydrogels.
• Alginate-based microparticle and microsphere vehicle development service: Microparticles or microspheres are solid colloidal particles with sizes in the 1 μm range. We use microfluidic methods, spray drying technology, epichlorohydrin chemical cross-linking, and other methods to prepare alginate microparticles or microspheres. They are suitable vehicles for hydrophilic drugs and have good loading and encapsulation efficiency for drugs.
• Alginate-based nanoparticle vehicle development service: Nanoparticles are typically nano-sized systems with diameters ranging from 10 to 1000 nm, and we offer diverse alginate nanoparticle development methods such as freeze-drying, spray freeze-drying, emulsification, and complexation.
• Alginate-based aerogel vehicle development service: Aerogels are porous, ultralight materials made using sol-gel chemistry. We offer flexible alginate aerogel development service where we disperse alginate and other materials in solution to form a sol, then introduce cross-linkers to induce the gel point and finally dry.
• Alginate-based micellar vehicle development service: Polymer micelles are effectively used for drug delivery, and since alginate is highly hydrophilic, we hydrophobically modify it to form amphiphilic copolymers for micelle preparation. Hydrophobically modified alginate is synthesized by derivatization of alginate with lauryl glycidyl ether in aqueous solution. Alginate-based composite hybrid micelles have better stability and higher drug-loading capacity, which have obvious advantages.

In addition, we also provide professional Alginate-based Vaccine Development and Alginate-based Tissue Gel Development services.

Fig.1 Alginate-based drug-delivery vehicle development service. (CD BioGlyco)

Publication

Technology: Sono-chemical strategy

Journal: International Journal of Biological Macromolecules

IF: 8.025

Published: 2023

Results: The authors created a simple sono-chemical strategy to prepare alginate-based microcapsules, which used oleic acid and thiolated alginate to modify Fe₃O₄ nanoparticles, while encapsulated hydrophobic drug models and coumarin 6 (a fluorescent dye) in magnetically reduced-responsive alginate-based microcapsules (MRAMCs). The result showed that the magnetic reduction of alginate-based microcapsules had broad application prospects in cancer treatment.

Fig.2 Alginate-based microcapsules synthesis schematic. (Wani, et al., 2023)

Applications

• Protein delivery: Alginate stabilizes proteins and facilitates their delivery within the body, which is used to prepare nanoparticles or microspheres of protein drugs, extend the plasma half-life of proteins, and improve bioavailability.
• Cancer research: Alginate is used as a drug delivery vehicle to help deliver anti-cancer drugs to tumor sites, improve drug efficacy, and reduce side effects. By changing the structure and properties of alginate, targeted release, controlled release, and pH responsiveness of drugs are achieved.
• Inflammation research: Alginate encapsulates anti-inflammatory drugs and releases drugs at the inflammatory site to reduce inflammatory symptoms and promote tissue repair.

Advantages

• Strong R&D capabilities: CD BioGlyco has professional technical teams with strong R&D capabilities. We provide the development and optimization of new alginate materials, explore innovative drug delivery strategies, and transform them into solutions that are applied to actual products.
• Unique solutions: CD BioGlyco provides clients with unique solutions from the design of alginate materials to drug delivery systems.
• Mature technology means: CD BioGlyco has mature alginate-related technology means, including technologies in material modification, drug encapsulation, and release control. We efficiently provide products and services that meet client requirements.

CD BioGlyco is one of the world's leading biopharmaceutical companies. We have the expertise and rich experience in the field of alginate and drug delivery, we flexibly respond to client needs and provide custom alginate-based drug delivery vehicle development service. Please feel free to contact us if you would like to get specific development content.