Fucoidan-based Vaccine Development Service

Fucoidan-based Vaccine Development Service at CD BioGlyco

Fucoidan is a class of acidic polysaccharides widely found in the cell walls of brown algae, with diverse biological activities such as antiviral, hypoglycemic, and intestinal microecological improvement. Its sulfation site and form affect its antiviral activity. Therefore, CD BioGlyco has proposed a fucoidan vaccine development program based on the characterization of its antiviral activity, which also includes the modification of fucoidan acidification sites.

Synthesis and Characterization of Fucoidan

Firstly, we prepare fucoidan with different sulfation site modifications by adopting a regioselective protection strategy using the microbial-assisted ring-opening polymerization reaction technique. The molecular weights and dispersion coefficients are determined by gel permeation chromatography (GPC).

Biological Activity Testing

The antiviral activity of fucoidan and its analogs depends on their sulfation site and form. Therefore, we test their antiviral activity. We chose a specific virus and incubated fucoidan with different sulfation sites together with the viral sting proteins to determine the binding inhibitory activity of fucoidan against the virus.

Vaccine Development

Fucoidan is tested for its antiviral activity and has been found to stimulate the host's natural immune system. Therefore, we develop antiviral or antitumor vaccines using it as an adjuvant targeting pattern recognition receptor types.

We provide in vivo experiments to evaluate the effectiveness of the vaccine: the vaccine containing different concentrations of fucoidan will be injected into mice, and under the same conditions, we compare the activity of viruses and tumor cells in the mice to obtain the effectiveness of the vaccine.

Fig.1 Development process of fucoidan-based vaccine. (CD BioGlyco)

Applications

• Fucoidan has the advantages of high biological activity and wide source. Therefore, it can be used as a novel antitumor agent or as an adjuvant in combination with antitumor agents.
• Fucoidan-based vaccine development can be used to assist in the development of anti-influenza and anti-viral drugs.
• Fucoidan-based vaccine development can be used to research certain physiological activities. Examples include mechanisms that regulate immunity, inhibit viruses, reduce infections, and protect cells.

Advantages of Us

• We have a professional R&D team to provide flexible and custom services according to clients' needs.
• We have industry-leading R&D technology to provide accurate, reliable, and high-quality results and products.
• We have a strong resource platform to help our clients with any research challenges.

CD BioGlyco is at the forefront of vaccine development technology and we offer high-quality vaccine development services to our global partners. We have the world's leading technology for Marine Carbohydrate Vaccine Development, and we hope to be your right hand in your research in this area. If you are interested in our services, please feel free to contact us.