Experience Excellence in Marine Glycosphingolipid (GSL) Production, Where Cutting-Edge Technology Meets Unmatched Quality for Pioneering Research
At CD BioGlyco, we are deeply engaged in marine biological resources, bringing unprecedented innovation power to scientific research and industry. Our Marine Biomolecule Production Services are vivid practices of this vision, focusing on extracting precious and unique biomolecules from the vast ocean. As the core branch of this service system, Marine Glycolipid Production Services came into being, focusing on the production of a series of marine glycolipid compounds with excellent biological activity and wide application potential.
Going deeper, marine GSL production service is one of the important contents of marine glycolipid production services. We rely on advanced biotechnology and chemical synthesis methods to carefully create various marine GSLs. These molecules are not only complex and diverse in structure but also play a key role in multiple life processes such as cell signaling, immune regulation, and neuroprotection. Through our professional services, clients obtain high-purity and well-defined marine GSLs, injecting strong vitality into their research and applications.
Marine Neutral GSL Production Service
- Marine Cerebroside Production Service
Marine cerebroside production service is dedicated to the production of neutral GSLs of cerebrosides from marine organisms. Cerebrosides play a key role in the nervous system and are involved in processes such as cell signaling, membrane stability, and neuroprotection. Our service ensures the production of high-purity, biologically stable marine cerebroside through advanced extraction and purification technologies, providing important support for neuroscience research, drug development, and treatment of neurodegenerative diseases.
- Marine Diosylceramide Production Service
Marine diosylceramide production service is dedicated to the production of marine-derived neutral GSLs of disaccharide ceramides. Due to their unique chemical structure and biological activity, these molecules have shown great potential in regulating cell proliferation, differentiation, and apoptosis. Our service meets the needs of different scientific research and industrial applications for diosylceramide purity and structural specificity through customized production.
- Marine Neutral GSLs with Oligosaccharide Chain Production Service
Marine neutral GSLs with oligosaccharide chain production service focuses on the production of marine neutral GSLs with oligosaccharide chains. These complex molecules not only have a high degree of structural diversity, but also exhibit a wide range of biological functions, such as immune regulation, cell recognition, and signal transduction. Our service uses advanced synthesis and modification technologies to precisely control the length, sequence, and connection of oligosaccharide chains to produce high-purity products that meet specific needs.
Marine Acidic GSL Production Service
Marine acidic GSL production service focuses on the efficient and stable production of acidic GSLs from marine organisms. Due to their unique chemical structure and wide range of biological activities, these molecules have extremely important application value in the fields of biomedicine, drug development, and functional materials.
- Marine Ganglioside Production Service
Marine GSL Production Process
- Collection and Pretreatment of Raw Materials
- Selected marine resources: We carefully select natural resources rich in GSLs from the deep sea, marine invertebrates, and microorganisms as raw materials.
- Pretreatment process: We carry out fine pretreatment of the collected raw materials, including washing, crushing, defatting, and other steps to remove impurities and improve the efficiency of subsequent extraction.
- Extraction and Separation
- Efficient extraction technology: We use advanced solvent extraction, ultrasonic-assisted extraction, or supercritical fluid extraction to effectively extract GSL components in raw materials. These technologies maximize the integrity and biological activity of active substances.
- Fine separation and purification: We use multi-stage chromatographic separation (such as ion exchange chromatography, gel filtration chromatography, and reverse phase chromatography), membrane filtration, crystallization, and other means to finely separate and purify the extract.
- Chemical Synthesis and Modification
- Customized synthesis: We provide customized synthesis services for GSL molecules with specific needs. Through precise chemical synthesis route design and optimization, GSL derivatives with specific structures and functions are synthesized.
- Structural modification: We use glycosyltransferase, sialyltransferase, and other biological enzymes or chemical methods to modify the structure of GSLs, such as sugar chain extension, sugar replacement, and sialylation to enhance their biological activity and stability.
- Quality Control and Testing
- Strict quality control system: We implement strict quality testing and control.
- Advanced analytical testing technology: We use high-performance liquid chromatography (HPLC), mass spectrometry (MS), nuclear magnetic resonance (NMR), and other advanced analytical testing technologies to conduct comprehensive quality analysis and evaluation of products.
Publication
Journal: Molecules
IF: 4.2
Published: 2011
Results: The authors investigated the novel GSL, β-D-GalNAcp(1→4)[α-D-Fucp(1→3)]-β-D-GlcNAcp(1→)Cer (A), isolated from the marine sponge Aplysinella rhax. This compound featured a unique structure, with D-fucose and N-acetyl-D-galactosamine moieties attached to a reducing-end N-acetyl-D-glucosamine via an α1→3 and β1→4 linkage, respectively. Findings suggested that the presence of a D-Fucα1-3GlcNAc-linkage, along with the ceramide aglycon portion, is essential for achieving optimal nitric oxide inhibition.
Fig.1 Synthesis of GSL. (Fujita, et al., 2011)
Applications
- Marine GSLs can participate in the intercellular communication process as signal molecules and are important tools for studying the cell signal transduction mechanism.
- The synthesis pathway and regulatory mechanism of marine GSLs provide valuable references for synthetic biology research. Through genetic engineering, metabolic pathways for synthesizing marine GSLs can be constructed in microorganisms to achieve large-scale production of these molecules.
- Marine GSLs are important tools for studying neurobiological phenomena and mechanisms and help reveal the mysteries of nervous system development and function.
Advantages
- Advanced biosynthesis technology: We have advanced marine GSL biosynthesis technology, which can efficiently and accurately regulate the synthesis process to ensure the diversity and stability of product structure.
- Strong R&D team: We have an R&D team composed of senior scientists with a deep background in biochemistry and molecular biology, focusing on basic research, application development, and technological innovation of marine GSLs.
- Global supply chain network: We have established a complete global supply chain network and established long-term and stable cooperative relationships with many well-known suppliers around the world. This ensures a stable supply of raw materials and the reliability of product quality while reducing production costs and improving the cost-effectiveness of products.
- Flexible customized services: We provide flexible customized services. We adjust the production process and formula according to the specific needs of clients to produce marine GSL products that meet client requirements.
Frequently Asked Questions
What is marine GSL?
Marine GSLs are a class of complex lipid molecules that are mainly found in marine organisms such as sponges, corals, and deep-sea microorganisms. They are composed of sugar groups (such as glucose and galactose) connected to sphingosine or its derivatives through glycosidic bonds. These molecules play an important role in cell recognition, signal transduction, and biomembrane stability, and have broad application prospects in medicine, cosmetics, and biomaterials due to their unique structure and biological activity.
How to ensure the stability of marine GSL during transportation?
We are well aware that marine GSLs are sensitive to conditions such as temperature and light, so we have taken a series of strict measures to ensure their stability during transportation. We use professional dry ice transportation to ensure that the products are transported under low-temperature conditions. At the same time, we also block the light packaging of the products to avoid damage to them by light. In addition, we also provide clients with detailed transportation guidelines and precautions to ensure that the products are properly kept during transportation.
Does your company provide after-sales service and technical support?
Yes, we attach great importance to after-sales service and technical support. Our client service team will provide clients with a full range of pre-sales consultations, in-sales guidance, and after-sales service. If clients encounter any problems or need technical support during use, we respond in time and provide professional solutions. In addition, we regularly visit clients to understand the use of the products and continuously improve our products and services based on client feedback.
At CD BioGlyco, our marine GSL production service takes advanced technology, strict quality control, flexible customized services, and environmentally friendly production concepts as its core competitiveness, providing clients with high-quality and high-purity GSL products and solutions. Please feel free to contact us for more details if you are interested in our marine GSL production service!
Reference
- Fujita, Y.; et al. Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues. Molecules. 2011, 16(1): 637-651.
