Extracellular Polysaccharide-based Tissue Scaffold Development Service

Extracellular Polysaccharide-based Tissue Scaffold Development Service at CD BioGlyco

CD BioGlyco has a comprehensive service for the development of tissue scaffolds based on many types of Marine Carbohydrates (Glycosaminoglycan, Chitin, Fucoidan, Extracellular polysaccharide, etc). Extracellular polysaccharides obtained from marine microorganisms (fungi, algae, and bacteria) are ideal candidates for the fabrication of tissue scaffolds. They are good antimicrobial, biocompatible, and anti-tumor materials. We offer tissue scaffold development services based on a wide range of extracellular polysaccharides, including but not limited to the following components:

Gellan Gum-based Tissue Scaffold Development Service

Gellan gum is a linear polysaccharide that is obtained naturally from Sphingomonas elodea. It consists of repeating tetrasaccharides, including two units of D-glucose and L-rhamnose, D-glucuronic acid. Gellan gum is widely used in the field of tissue regeneration and other applications due to its flexible mechanical properties and good biocompatibility. We provide gellan gum-based hydrogel development services. Gellan gum-based hydrogels have significant advantages with high water content and good thermal response. In addition to hydrogels, we also provide gellan gum-based electrostatically spun nanofibers development services. The nanofibers are used to accelerate the repair of skin tissues, thus effectively enabling the regeneration process of epithelial tissues.

We also enhance the functional properties of the polymers by Chemically Modifying or physically modifying gellan gum. Our goal is to optimize the cell binding, mechanical integrity, rheological, and processing properties of gellan gum.

Xanthan Gum-based Tissue Scaffold Development Service

Xanthan gum is a water-soluble polysaccharide extracted from the fermentation of Xanthomonas campestris. Xanthan gum has shear thinning properties, good water solubility, antimicrobial properties, and anionic properties. We offer xanthan gum-based nanoparticles, hydrogels, and multifactorial bioscaffold fabrication services. These scaffolds have protein adsorption efficiency, good mechanical properties, and degradability. They have desirable effects and functions in tissue regeneration, etc.

The xanthan gum has disadvantages such as poor mechanical properties and lack of cell attachment sites. Therefore, we use xanthan gum in combination with other substances to enhance its natural advantages.

Tissue Scaffold Development Services Based on Other Extracellular Polysaccharides

Extracellular polysaccharides, as natural extracellular components of microorganisms, are uniquely suited to mimic the extracellular matrix. We also provide tissue scaffold development services based on other extracellular polysaccharides. We optimize the characteristics of the scaffolds, including porosity, biocompatibility, pore interconnectivity, layered morphology, mechanical resistance, and others according to client requirements.

Fig.1 Types of tissue scaffolds developed based on extracellular polysaccharides. (CD BioGlyco)

Publication Data

Technology: Physical crosslinking

Journal: Carbohydrate polymers

IF: 9.381

Published: 2020

Results: In this study, Poly (acrylamide-co-acrylonitrile) (P(AAm-co-AN)), erric ion (Fe³⁺), and montmorillonite (MMT) were introduced into xanthan gum (XG). A novel hydrogel (XG/MMT/PAAm) was prepared by this method. Characterization of the structure and properties of this hydrogel showed that the hydrogel pore size decreased with increasing amounts of XG, indicating the emergence of a denser and more homogeneous structure. At the same time, it exhibits good shape recovery, compressive stress, and high-strain stress. The hydrogel is promising for applications such as tissue engineering.

Fig.2 Schematic illustration of the preparation of XG/MMT/PAAm hydrogel. (Hua, et al., 2020)

Applications

• Extracellular polysaccharide-based tissue scaffolds are used for tissue regeneration, such as maintaining the delivery and growth of human articular chondrocytes.
• Extracellular polysaccharide-based hydrogels have antimicrobial effects on common wounds and are used as wound dressings.
• Extracellular polysaccharide-based biomaterials are used for research in areas such as flexible conductive devices.

Highlights of Us

• There are various kinds of extracellular polysaccharides. We are capable of fabricating tissue scaffold development services based on different kinds of extracellular polysaccharides.
• With our extensive experience in tissue scaffold fabrication, we offer tissue scaffold development services based on a variety of extracellular polysaccharides.
• We optimize the properties of the tissue scaffolds through various modifications, including porosity, layered morphology, mechanical resistance, and biocompatibility.

CD BioGlyco is constantly optimizing and updating technologies and processes related to tissue engineering. Our goal is to give our clients who choose us the best products and the most efficient service. Please feel free to contact us to tell us about your needs if you are interested in our extracellular polysaccharide-based tissue scaffold development services. Our specialized marine carbohydrate research team is ready to serve you at any time.