Marine Carbohydrate-based Drug-Delivery Vehicle Development Service at CD BioGlyco
Marine carbohydrates are natural products extracted from marine organisms, which have good biocompatibility and biodegradability. They are structurally diverse and achieve good drug encapsulation and protection effects through appropriate modifications and adjustments, which makes marine carbohydrate vehicles a potential platform for developing drug delivery systems. CD BioGlyco has a professional technical team, and we focus on providing high-level marine carbohydrate-based drug delivery vehicle development services.
- Marine carbohydrate-based screening and assessment service: We provide screening and evaluation for various marine-derived carbohydrates, including physical and chemical property testing and preliminary activity assessment, through which candidates with potential drug delivery applications are identified.
- Marine carbohydrate-based drug delivery vehicle design and optimization service: We screen suitable marine carbohydrates as drug delivery vehicles according to drug properties and client needs. Based on selected marine carbohydrates, we design and optimize the composition, structure, and properties of drug-delivery vehicles to achieve drug encapsulation, protection, and targeted delivery.
- Marine carbohydrate-based drug delivery vehicle preparation and development service: Based on the selected marine carbohydrate vehicle, we research and develop preparation technologies suitable for specific vehicles, including the micelle method, nanoparticle preparation, liposome preparation, film preparation, etc. We provide development for multiple types of marine carbohydrate-based drug delivery vehicles through mature preparation processes.
Alginate is an acidic marine colloidal polysaccharide, mainly extracted from kelp and Ascophyllum nodosum. CD BioGlyco provides diversified alginate-based drug delivery vehicle development services.
CG is a naturally occurring anionic sulfated polysaccharide extracted primarily from algae, which usually contains three structures: λ-CG, κ-CG, and ι-CG. CD BioGlyco provides specialized CG-based drug delivery vehicle development service.
Ulvan is a natural polysaccharide extracted from seaweed and is a type of sulfated polysaccharide. CD BioGlyco adopts appropriate extraction methods to obtain high-quality ulvan and provides mature ulvan-based drug delivery vehicle development service according to the required drug delivery properties.
Laminaran is a polysaccharide extracted from brown seaweed and belongs to the β-glucan category. After modifying and functionalizing the laminaran, we design and prepare laminaran-based drug delivery vehicles.
Fucoidan is mainly found in certain species of Phaeophyta. It has a complex chemical structure composed of simple sugars such as fucose and galactose. CD BioGlyco provides high-quality fucoidan-based drug-delivery vehicle development service.
Agar is a natural polysaccharide extracted from red algae, which has gelling ability and good biocompatibility. We load drugs or therapeutics into the agar matrix and optimize its physical and chemical properties for more efficient drug delivery.
Galactan is a polysaccharide composed mainly of galactose, which is extracted from different sources. It is biocompatible and degradable and has potential applications in the field of drug delivery. CD BioGlyco provides flexible galactan-based drug-delivery vehicle development services.
Chitin is a natural polysaccharide found mainly in the exoskeletons and cell walls of crustaceans, insects and fungi. CD BioGlyco develops using chitin as a basis for drug delivery vehicles, which achieves more effective drug delivery.
Chitosan is a natural polysaccharide obtained through deacetylation. It is primarily derived from the shells of crustaceans such as shrimp, crabs and shellfish. We provide custom chitosan-based drug-delivery vehicle development service according to client needs.
Porphyran is a polysaccharide extracted from red algae and belongs to the sulfated polysaccharide family, which has a variety of biological activities and medicinal potential. Based on this, CD BioGlyco provides a one-stop porphyran-based vehicle development service.
Pectin is a natural polysaccharide derived from cell walls. It has good compatibility with a variety of drugs and is used for various types of drug delivery. CD BioGlyco provides diversified pectin-based drug-delivery vehicle development service.
CD BioGlyco utilizes the properties of heparin to design and develop vehicles for controlled release of drugs. These vehicles encapsulate drugs inside and improve the drug's efficacy and reduce side effects by controlling the release rate and targeting.
Chondroitin sulfate is found in cartilage, bones, and connective tissues of marine organisms and mammals. It consists of alternating arrangements of glucuronic acid and N-acetylgalactosamine. CD BioGlyco provides high-quality vehicle development service.
Dermatan sulfate is a natural polysaccharide that exists in the tissues of marine animals. As a vehicle, dermatan sulfate provides better stability, biocompatibility, and targeting, supporting the effective delivery of drugs.
Hyaluronan has many important physiological functions and has broad application potential in drug delivery systems due to its biocompatibility and biodegradability. CD BioGlyco provides high-level hyaluronan-based drug-delivery vehicle development services.
Heparan sulfate is a polysaccharide that occurs naturally in animals, which interacts with specific biomolecules to provide better drug delivery capabilities. We provide mature heparan sulfate-based drug-delivery vehicle development service through advanced technology.
Keratan sulfate is a naturally occurring polysaccharide found in animals and humans. We combine keratan sulfate with suitable materials such as polymers or nanoparticles to develop stable drug delivery vehicles.
- Marine carbohydrate-based drug delivery vehicle characterization and analysis service: We offer a diverse range of characterization and analysis for marine carbohydrate-based drug delivery vehicles to evaluate the quality and performance of the vehicles.
- Morphology determination: We use instruments such as scanning electron microscope (SEM) or atomic force microscope (AFM) to observe and analyze the surface morphology of the delivery vehicle to help understand the morphology, particle size distribution, and surface structure of the vehicle.
- Particle size determination: We use tools such as particle size analyzer, dynamic light scattering (DLS), or laser particle size analyzer to measure and analyze the particle size distribution of the vehicle, which helps determine the particle size characteristics and dispersion performance of the vehicle.
- Determination of drug encapsulation rate: We measure the drug encapsulation rate in the vehicle through high-performance liquid chromatography (HPLC), ultraviolet-visible spectrophotometer (UV-Vis), and other methods, which evaluate the vehicle's encapsulation efficiency of the drug.
- Drug loading capacity determination: We use appropriate analytical methods, such as thermogravimetric analysis (TGA) or dissolution experiments, to test and analyze the drug loading capacity in the vehicle, which helps to understand the drug absorption capacity and drug release performance of the vehicle.
- Drug delivery performance evaluation: We evaluate the drug delivery performance of the vehicle through in vitro or in vivo experiments, including drug release kinetics, drug stability, cellular uptake, and other experiments.
- Biocompatibility and safety assessment: We evaluate the biocompatibility and safety of marine carbohydrate vehicles through cytotoxicity testing, histocompatibility studies, and in vivo safety assessment to ensure their feasibility and safety in clinical application.
In addition, as a leading global biotechnology company, CD BioGlyco is committed to providing high-precision development of various types based on marine carbohydrates, such as Marine Carbohydrate-based Biomarker Development Service and Marine Carbohydrate-based Biomaterial Engineering Development Service.
Fig.1 Marine carbohydrate-based drug-delivery vehicle development service. (CD BioGlyco)
Publication
Technology: Emulsification, spraying, agglomeration, and other techniques
Journal: Pharmaceutics
IF: 6.525
Published: 2023
Results: Marine polysaccharides have been widely used as drug delivery vehicles. In this article, the authors reviewed the existing literature and listed some promising marine polysaccharides as drug microcarriers, such as chitosan, alginate, fucoidan, carrageenan, etc. These polysaccharides were used to prepare vehicle particles that delivered drugs through emulsification, spraying, agglomeration, and other techniques. Moreover, These microparticles were used as vehicles for drug delivery systems in different locations, such as oral, nasal, skin, eye, etc.
Fig.2 Source and structure of marine polysaccharides. (Lukova & Katsarov, 2023)
Applications
- Drug delivery system: Marine carbohydrates are used as vehicles for drug delivery to help deliver drugs accurately and persistently into specific tissues or cells. For example, marine carbohydrates are used as vehicles for anti-inflammatory drugs, helping to deliver them to sites of inflammation and speed up the healing process.
- Tissue engineering: Marine carbohydrates are used to construct tissue engineering scaffolds and nanoparticles for tissue repair and regeneration engineering.
- Infectious disease prevention: The development of antibacterial drug delivery systems based on marine carbohydrates improves the targeting and effectiveness of drugs at the site of infection.
Advantages
- Diverse vehicle design: Our technical team has diverse vehicle design capabilities, and designs efficient and stable marine carbohydrate drug delivery vehicles according to different drug properties and target application requirements.
- Micro- and nano-scale vehicle preparation: We master the top micro- and nano-scale vehicle preparation technology and prepare marine carbohydrate-based drug delivery vehicles with ideal particle sizes and surface properties.
- Multifunctional vehicle development: We develop multifunctional marine carbohydrate-based drug delivery vehicles, such as controlled release systems, targeted delivery systems, etc, and provide corresponding vehicle biocompatibility assessment and optimization service.
CD BioGlyco has established an industry-leading marine carbohydrate development solution. We have advanced marine biotechnology and purification technology to extract and purify marine carbohydrates and meet the requirements for drug delivery vehicle development. We develop marine carbohydrate-based drug delivery vehicles suitable for specific drugs or therapeutic areas according to client needs and goals. Please feel free to contact us if you need specific vehicle development details.
Reference
- Lukova, P.; Katsarov, P. Contemporary aspects of designing marine polysaccharide microparticles as drug carriers for biomedical application. Pharmaceutics. 2023, 15(8): 2126.
