Marine Glycan Derivatization Service

Marine Glycan Derivatization Service at CD BioGlyco

Marine glycan is a general term for a variety of carbohydrates extracted from the ocean, including polysaccharides from algae, marine fungi, marine animals, and other sources. Marine glycans are a class of complex biological macromolecules with a variety of physiological activities and biological functions, such as antitumor, immunomodulation, antioxidant, and so on. Derivatives of marine glycans are compounds obtained by chemical modification or transformation of marine sugars. Obtaining derivatives with different properties and functions by altering the structure of marine sugar molecules is the current direction of attention of many researchers. CD BioGlyco concentrates on marine glycan-related research and provides specialized Marine Biomolecule Production Services, Marine Carbohydrate Characterization Services, and Marine Glycomics Services. Among them, our Marine Glycan Release, Separation and Purification, derivatization, and subsequent Characterization Services receive favor from clients. The details of our marine glycan derivatization service are as follows:

• First, we select appropriate marine organisms, perform preliminary treatment of the samples to remove impurities and solid particles, and use appropriate solvents for extraction. The extracted solution is filtered, concentrated, and purified to obtain a high-purity sample of the target marine glycan.
• Then, we select appropriate derivatization reagents, which include chemical reagents, such as acylation reagents, esterification reagents, substitution reagents, etc., and markers, such as fluorescent dyes and radioisotopes, according to the research objectives and needs. The reaction conditions are optimally adjusted according to the specific derivatization reagents and the nature of the marine glycans. The reaction can be monitored and analyzed by chromatographic techniques or mass spectrometry to determine the course and products of the reaction.
• Finally, we determine the structure and composition of the derivatized marine sugars by structural analysis. The various properties of the derivatized marine sugars, including solubility, thermal stability, optical spin, antioxidant properties, etc., are evaluated and determined by property characterization.

Fig.1 Common derivatives of marine glycans. (CD BioGlyco)

Publication Data

Technology: NMR, cytotoxicity assay, and DNA damage assay

Journal: Marine drugs

IF: 5.4

Published: 2018

Results: The structural characteristics of marine sugars and glycoproteins play a decisive role in their pharmacological properties, such as the length of the sugar chain, the composition of monosaccharides, the presence, type, and degree of substituents, etc. The medicinal properties of marine carbohydrate compounds are also discussed. Some marine carbohydrate compounds related to medicinal properties are mentioned, such as fucosylated chondroitin sulfate(fCS) from sea cucumbers, propylene glycol alginate sodium sulfate (PSS) from seaweed, and some proteins from marine organisms that have anti-inflammatory, anti-cancer, and other effects. These compounds have antioxidant activity and anti-inflammatory effects that can reduce the inflammatory response and symptoms of inflammation-related diseases. Specifically, they exert their antioxidant and anti-inflammatory activity over their structural properties, such as the length of sugar chains, monosaccharide composition, and the presence and type of substituents such as sulfation and acetylation.

Fig.2 Overview of marine-derived polysaccharides in alleviating oxidative stress-mediated diseases. (Zhong, et al., 2019)

Applications

• Marine sugar derivatives are applied as crucial thickeners and emulsifiers in industries such as pharmaceuticals.
• Marine sugar derivatives are biocompatible and biodegradable and are therefore used as biomaterials in the medical field.
• Marine sugar derivatives are used as biosorbents for sewage and wastewater treatment to remove heavy metal ions and organic matter.

Advantages

• Derivatization of marine glycans expands their potential applications and better suits your research in various directions.
• Marine sugars may be prone to degradation under some conditions, and the derived marine sugars can be given higher stability according to their structural modification, ensuring that they have longer shelf life and better performance in practical applications.
• We fine-tune the properties of sugars for your specific application by modifying their structure, size, charge, or hydrophobicity, depending on your specific needs.

CD BioGlyco innovates and creates sustainable techniques for marine glycan derivatization to meet the needs across diverse industries of our clients. Our focus includes ensuring that these techniques are viable not only in the lab but also in large-scale production environments. If you are interested in our services, we warmly invite you to contact us for further comprehensive information.