Marine Carbohydrate-based Biomarker Development Service at CD BioGlyco
Carbohydrate-rich compounds from marine sources, such as algae, microorganisms, and aquatic animals, are known for their biodegradable and biocompatible nature. These compounds exhibit intrinsic biological properties, contributing to the exploration of diverse bioactive substances with unique pharmacological applications in medicine. Particularly, marine bioactive compounds have demonstrated promise as cancer biomarkers, influencing proteins, DNA, RNA, and related molecules. Their potential to induce apoptosis and autophagy suggests a role in inhibiting cancer pathways, while also modulating inflammation-related pathways and dynamically regulating the cancer epigenome in cancer theragnosis. Based on these potential applications and bioactivities, marine carbohydrates are used to research biomarker development. At CD BioGlyco, we have established a powerful lab platform that provides marine carbohydrate-based biomarker development services.
Fig.1 Marine bioactive compounds as magic bullets in the regulation of cancer. (Patra, et al., 2020)
At CD BioGlyco, we offer marine carbohydrate-based biomarker development services, which involve the identification of specific carbohydrate molecules (glycans) in marine organisms or of marine origin, the characterization of the glycan molecules, and the development of related applications. The following is the standard process of the development service, the Glycan Characterization Service for getting the target marine glycan, and we also provide Marine Carbohydrate Production Service for clients to directly get the molecules they want. If you would like to explore some unnatural marine glycan and study their potential application in biomarker development, please see our Marine Glycoconjugate Development Service.
Fig.2 Marine carbohydrate biomarker development service. (CD BioGlyco)
CD BioGlyco has already developed several marine carbohydrate-based biomarker development services for clients, which include fucan, red algae resource, green algae resource, chitooligosaccharide, glycerine, and glycoxidation-related molecules. Some of them are directly used to develop biomarkers and some of them are basic reagents used in biomarker development. Based on these molecules and our outstanding R&D team, we help our clients explore the potential application of marine resources. Here are our up-to-date development services, and we are also looking forward to helping our clients do some custom services besides the services listed.
Fucans are sulfated polysaccharides found in various marine organisms such as brown algae. They have potential biological activities and applications.
Red algae are known to contain various carbohydrates, including polysaccharides that contribute to their structural integrity and other biological functions.
Green algae, or chlorophyta, are a diverse group of photosynthetic organisms that can be found in various aquatic environments.
Chitooligosaccharides are oligomers of N-acetylglucosamine (GlcNAc), derived from the partial hydrolysis of chitin.
Glycerine is a simple polyol compound that is colorless, odorless, and sweet-tasting. Glycerine itself is not typically considered a biomarker.
Glycoxidation leads to the formation of advanced glycation end products (AGEs) and reactive oxygen species (ROS).
Publication
Technology: Marine natural products, Drug delivery, Three-dimensional cancer models
Journal: Marine Drugs
IF: 5.4
Published: 2022
Results: Pancreatic cancer (PC) remains largely incurable, underscoring the urgency for novel therapies. The vast potential of marine-derived compounds for drug discovery requires collaborative efforts to tap into the sea's biodiversity, identify unique compounds, and assess their biological activities. The current challenge lies in efficiently accessing this natural chemical diversity. Simultaneously, the development of specific biomarkers for treatment monitoring poses a hurdle in PC. Advances in new drug availability, early diagnostics, prognostic methods, and innovative cancer research models promise to enhance survival rates for this formidable disease.
Fig.3 The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). (Fernandes, et al., 2022)
Applications
- Marine carbohydrates serve as potential cancer biomarkers, aiding in the early detection and monitoring of various cancers. Their unique properties are leveraged for developing diagnostic tools and personalized treatment strategies.
- Marine-derived carbohydrates offer a rich source for drug discovery. By exploring the diverse chemical structures of these compounds, researchers identify novel drug candidates with therapeutic potential for various diseases, including cancer and infectious diseases.
- Marine carbohydrates play a role in the dynamic regulation of the cancer epigenome. Understanding their impact on epigenetic processes leads to the development of therapies targeting epigenetic modifications in cancer cells.
Advantages
- We have a well-equipment lab that not only provides marine carbohydrates but also provides other Marine Biomolecules to help clients study the field of marine sugar.
- We have a team of professional and rich-experiment scientists who bring our clients the most suitable custom solution for biomarkers.
- Our lab team is highly skilled, collaborative, and dedicated, ensuring efficient and accurate execution of experiments and producing high-quality research outcomes.
CD BioGlyco is a company with extensive glycan chemistry research experience and aims to be clients' best glycan research cooperator. Depending on the development of marine glycan applications, more and more researchers pay attention to this field, and our outstanding biomarker development services are your good choice for speeding up your research on marine glycan. Please do not hesitate to contact us for more information about our services and we appreciate any news from your end.
References
- Patra, S.; et al. Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways. Molecular Biology Reports. 2020, 47: 7209-7228.
- Fernandes, A.S.; et al. Marine-inspired drugs and biomaterials in the perspective of pancreatic cancer therapies. Marine Drugs. 2022, 20(11): 689.
