Chemical Modification of Marine Carbohydrates

Chemical Modification of Marine Carbohydrates at CD BioGlyco

At CD BioGlyco, our research team is well-versed in different types of chemical modifications and route optimization. Marine Carbohydrates are chemically modified to change their properties for specific purposes. Derivatives synthesized through chemical modification are currently being used in areas such as wastewater treatment, etc. In addition to Marine Carbohydrate-Polymer Conjugation and Enzyme Modification Services, we also provide a high-quality chemical modification service for marine carbohydrates to clients engaged in various fields of research such as biomedical research and tissue engineering. Our chemical modifications of marine carbohydrates include modification of chitosan, etc. We aim to change the properties of biomaterials and improve the biological activity of compounds through chemical modification.

Chemically Modification of Chitosan

Chitosan is a natural aminopolysaccharide. It contains primary as well as secondary hydroxyl group (-OH) and amino (-NH2) functional groups, which can be modified by chemical modification. The chemically modified chitosan has altered structure, properties, etc., and has good application prospects. Without affecting the degree of polymerization of chitosan, we offer many types of chemical modifications of chitosan, including O-substitution, N-substitution, and affixation with other compounds. Alkylation, sulfation, acylation, thiolation, quaternization, carboxymethylation, phthaloylation, etc., are possible.

Fig.1 Classes of chemically modified chitosan. (CD BioGlyco)

Chemically Modification of Fucosylated Chondroitin Sulfate

Fucosylated chondroitin sulfate (fCSs) is a structurally unique glycosaminoglycan. We chemically modify fCSs by mild acid hydrolysis as well as desulfation reaction, and other treatments. With a high level of problem-solving ability and a high project success rate, we are capable of accomplishing a wide range of chemical modification challenges.

Publication Data

Technology: Chemical modification

Journal: Arabian Journal of Chemistry

IF:3.725

Published: 2014

Results: In this study, chitosan was chemically modified using various methods, including modification with aldehydes, modification with acids, suffixation of chitosan with other compounds, etc. The modified chitosan derivatives were also characterized using Fourier transform infrared spectroscopy analysis. The results showed that chemical modification of chitosan is feasible and easy. All modified chitosan products showed a good ability to absorb metal ions from an aqueous solution. Aldehyde-modified chitosan had better absorption capacity.

Fig.2 Polymer capacity of modified Chitosan derivatives of FeCl₃ and CuSO₄. (Galhoum, et al., 2017)

Applications

• Chitosan derivatives synthesized through chemical modification are used to develop various drug slow-release systems to achieve controlled diffusion of drugs.
• Chitosan derivatives synthesized through chemical modification are used for water treatment (biosorption of dyes and heavy metals), cosmetics, etc.
• Marine carbohydrate derivatives synthesized by chemical modification can be mixed with other compounds for the preparation of food packaging materials.

Advantages of Us

• We combine our technological strengths with a high-quality research team to provide our clients with chemical modification services based on marine carbohydrates.
• Our chemical modifications for chitosan are diverse, such as nucleophilic substitution reactions at the amino group, graft copolymerization, etc.
• With our extensive experience in chemical modification, we realize many types of chemical modifications on chitosan, fCSs, etc.

CD BioGlyco provides customized chemical modification services for marine carbohydrates. Please feel free to contact us for more information about the type of chemical modification and tell us the purpose of your experiment. We are ready to fulfill any of your research needs.