Marine Carbohydrate-based Vaccine Development Service

Marine Carbohydrate-based Vaccine Development Service at CD BioGlyco

Marine carbohydrates have more specific structural and biological functions than terrestrial carbohydrates. CD BioGlyco offers high-quality marine carbohydrate vaccine development services in conjunction with the Vaccine Adjuvant Production process.

Synthesis of Marine Carbohydrate Adjuvants

Marine carbohydrates have immunomodulatory functions, and their assembly into nanoparticles further enhances their function as vaccine adjuvants. We prepare marine carbohydrate nanoparticles using the ionic gel method, dialysis method, and emulsion method.

Since the immunostimulatory properties of nanoparticles are closely related to their particle size. We introduce chemical modifications to enhance the function of marine carbohydrate nanoparticles as vaccine adjuvants. A molecular mechanism is adopted to explore the mechanism of their promotion of immune response.

In addition, to further improve the functionality of marine carbohydrate nanoparticles as vaccine adjuvants, we use different cross-linking agents to assist the synthesis. For example, dextran is a favorable cross-linking agent.

Development of a Marine Carbohydrate Vaccine

We combined the prepared nanoparticles with different antigens to identify the antigen that triggers the immune response, and screen and evaluate the ability of the antigen to induce the production of antibodies.

Next, vaccines are prepared by assembling the antigens with stabilizers, surfactants, and other substances. Experimental vaccines are first tested in animals to assess their safety and their potential to prevent disease.

We analyze and test the safety as well as multiple properties of the vaccine. Tests include but are not limited to.

• Physical and chemical items such as identification test, appearance, osmotic pressure, pH value, etc.
• Safety items such as sterility tests, abnormal toxicity bacterial endotoxin tests, etc.
• Evaluation of the structure, purity, antigenicity, immunogenicity, and stability of vaccines

In addition, the protective effect of the vaccine is evaluated using pathogen attack tests for some infectious diseases for which animal models are available.

Fig.1 Marine carbohydrate vaccine development process. (CD BioGlyco)

Publication Data

Journal: Carbohydrate Research

Published: 2021

Results: Viral infections have some adverse effects on the affected individuals. Among the current therapeutic and prophylactic measures, the reuse of antiviral drugs has emerged as a suitable strategy. Sulfated marine polysaccharides, based on the accumulation of data, have so far been successful in inhibiting viral entry, attachment, and replication against deadly animal and human viruses. Additionally, viral infections caused by virus types can trigger severe oxidative stress in the human body, leading to tissue and organ dysfunction. In this context, polysaccharides play a very important role in providing a shielding effect against viruses due to their polyanion-rich nature and molecular weight that hinders their reactive surface glycoproteins. Notably functional groups, especially sulfates, sulfate patterns and adducts, glyoxalates, monosaccharides, glycosidic bonds, and high molecular weights have a greater influence on antiviral activity. Marine polysaccharides have a greater effect of glycosidic bonding and high molecular weight on antiviral activity. Thus, polysaccharides can be used as vaccine adjuvants or in combination with other antiviral drugs, antioxidants, and immune-activating nutritional supplements, as well as antiviral materials in nutraceuticals to prevent viruses.

Applications

• Marine carbohydrate vaccine development can be used to explore antigen adsorption, mucosal adhesion, and immune receptor interactions.
• The marine carbohydrate vaccine development can be used to explore the function of carbohydrates in cell signaling.
• Marine carbohydrate vaccine development could help advance the development of marine monosaccharides, oligosaccharides, or polysaccharides in the medical field.

Advantages

• We have a professional marine carbohydrates R&D team that utilizes the latest methods and tools to provide custom vaccine R&D solutions for our clients.
• We have a strict quality management system and production standards to ensure we offer high-quality products.
• We have leading vaccine development technology to ensure that our clients' experimental needs are met.

CD BioGlyco offers flexible and trustworthy marine compound vaccine development services. Our R&D programs are developed by experts and have passed quality tests. Client satisfaction is our relentless pursuit. If you have any questions about marine carbohydrate vaccine-related services please feel free to contact us.