Overview
Marine carbohydrates, sourced from the diverse marine ecosystem, are a frontier in biomaterial science. These
natural polymers—including chitosan, fucoidan, alginate, hyaluronic acid, and xanthan—have unique biological
activities and physicochemical properties. CD BioGlyco taps into the potential of these marine
resources, turning them into specialized derivatives. Our advanced marine carbohydrate derivatives are
engineered to boost solubility, bioavailability, stability, and specific functionalities, creating new
opportunities across industries. We deliver high-quality, customized solutions to meet global clients' evolving
needs, advancing pharmaceuticals, cosmetics, food science, etc.
Core Technologies
CD BioGlyco uses cutting-edge technologies to develop superior marine carbohydrate derivatives. Our expertise
covers advanced techniques ensuring quality and tailored functionalities:
Controlled chemical synthesis: We enable targeted derivatization of marine carbohydrates via reactions
like carboxymethylation, sulfation, acetylation, and cross-linking—key for modifying solubility, charge, and
mechanical properties.
Advanced purification: Sophisticated chromatography, ultrafiltration, and precipitation methods achieve high
purity, vital for pharmaceutical and biomedicine applications.
Comprehensive characterization: Each derivative undergoes rigorous testing with nuclear magnetic resonance (NMR),
mass spectrometry (MS), Fourier-transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), and
differential scanning calorimetry (DSC) to confirm molecular weight, structure, and properties.
Tailored Marine Carbohydrate Derivatives for Diverse Industries
CD BioGlyco offers an extensive portfolio of marine carbohydrate derivative products, providing innovative
solutions for a wide array of industrial and research applications. Our offerings are categorized by the
foundational marine polysaccharide, each meticulously modified to unlock enhanced functionalities.
Chitosan, derived from chitin, is renowned for its exceptional biocompatibility, biodegradability, and versatile
properties. Our chitosan derivatives are expertly engineered to improve solubility, enhance biological activity, and
expand their application versatility across various fields. We have successfully coupled over 100 different
functional groups, including hydroxyl, carboxyl, Iodoacetate, DBCO, TCO, biotin, heparin, BSA, amino, and NHS, with
chitosan to generate a wide variety of advanced conjugates for diverse applications. Representative products include
chitosan-PEG-OH, chitosan-PEG-COOH, and chitosan-PEG-iodoacetate.
| Cat. No. |
Product Name |
| X24-04-YM007 |
Chitosan lactate, Alaskan crab |
| X24-12-YM001
|
Poly
aspartic acid reagent, Poly aspartic acid-PEG-chitosan, 350 Da, Purity ≥ 98% |
| X24-12-YM011 |
Arginine reagent,
Arginine-PEG-chitosan, 350 Da, Purity ≥ 98% |
| X24-12-YM021 |
Adamantane reagent,
Adamantane-PEG-chitosan, 350 Da, Purity ≥ 98% |
| X24-12-YM034 |
Isocyanate reagent,
Isocyanate-PEG-chitosan, 1 kDa, Purity ≥ 98% |
| X24-12-YM046 |
6-FAM reagent,
6-FAM-PEG-chitosan, 3 kDa, Purity ≥ 98% |
| X24-12-YM051 |
DMG reagent, DMG-PEG-chitosan, 350
Da, Purity ≥ 98% |
| X24-12-YM065 |
DOPE reagent, DOPE-PEG-chitosan, 2
kDa, Purity ≥ 98% |
| X24-12-YM073 |
Cyanur reagent,
Cyanur-PEG-chitosan, 750 Da, Purity ≥ 98% |
Fucoidan, a sulfated polysaccharide isolated from brown seaweed, is celebrated for its diverse and potent
biological activities. Our fucoidan derivatives are designed to optimize these inherent properties for targeted
applications, enhancing their therapeutic and functional potential. We have successfully coupled over 100 groups or
compounds such as catalase, streptavidins, casein, biotin, heparin, Insulin, ovalbumin, and Concanavalin A with
fucoidan to generate a comprehensive range of conjugates, such as fucoidan-chitosan nanoparticles for improved drug
delivery.
| Cat. No. |
Product Name |
| X25-02-ZQ2520 |
DBCO reagent, DBCO-PEG-fucoidan, Purity
≥95% |
| X25-02-ZQ253
|
Wheat
germ agglutinin reagent, Wheat germ agglutinin-PEG-fucoidan, PEG 1 kDa, Purity ≥95% |
| X25-02-ZQ2530 |
Vinylsulfone reagent,
Vinylsulfone-PEG-fucoidan, Purity ≥95% |
| X25-02-ZQ254
|
Wheat
germ agglutinin reagent, Wheat germ agglutinin-PEG-fucoidan, PEG 2 kDa, Purity ≥95% |
| X25-02-ZQ2540 |
Tretinoin reagent,
Tretinoin-PEG-fucoidan, Purity ≥95% |
| X25-02-ZQ255
|
Wheat
germ agglutinin reagent, Wheat germ agglutinin-PEG-fucoidan, PEG 3 kDa, Purity ≥95% |
| X25-02-ZQ2550 |
Silane reagent, Silane-PEG-fucoidan,
Purity ≥95% |
| X25-02-ZQ2560 |
TCO reagent, TCO-PEG-fucoidan, Purity
≥95% |
Alginate, sourced from brown algae, is highly prized for its exceptional gelling properties, biocompatibility, and
versatility in forming hydrogels. Our alginate derivatives are engineered to enhance these characteristics,
broadening their utility and performance across numerous applications. We have successfully coupled over 100 groups
or compounds, such as FAM, tosyl, epoxide, phenyl, vinylsulfone, isothiocyanate, MAL, amino, and transferrin with
alginate to generate a diverse array of conjugates for various fields.
| Cat. No. |
Product Name |
| X25-02-ZQ109 |
FAM reagent, FAM-alginate
oligosaccharides, Purity ≥95% |
| X25-04-YM1000 |
Tosyl agent, Alginate-PEG-tosyl, Purity
≥95% |
| X25-04-YM1001 |
Epoxide agent, Alginate-PEG-epoxide,
Purity ≥95% |
| X25-04-YM1002 |
Phenyl agent, Alginate-PEG-phenyl,
Purity ≥95% |
| X25-04-YM1003 |
Vinylsulfone agent,
Alginate-PEG-vinylsulfone, Purity ≥95% |
| X25-04-YM1004 |
Isothiocyanate agent,
Alginate-PEG-isothiocyanate, Purity ≥95% |
| X25-04-YM1005 |
MAL agent, Alginate-PEG-maleimide,
Purity ≥95% |
| X25-04-YM1006 |
Methacrylate agent,
Alginate-PEG-methacrylate, Purity ≥95% |
Hyaluronic acid, a vital component of connective tissues, is renowned for its remarkable viscoelasticity,
moisturizing properties, and biocompatibility. Our HA derivatives are meticulously designed to expand their
therapeutic and cosmetic applications, offering enhanced stability and functionality. We have successfully coupled
key compounds like FITC and curcumin with hyaluronic acid of different molecular weights to generate a variety of
conjugates for diverse fields.
| Cat. No. |
Product Name |
| X25-02-ZQ028 |
FITC reagent, Hyaluronic
acid-FITC, HA 2 kDa, Purity ≥95% |
| X25-02-ZQ029 |
FITC reagent, Hyaluronic
acid-FITC, HA 5 kDa, Purity ≥95% |
| X25-02-ZQ030 |
FITC reagent, Hyaluronic
acid-FITC, HA 10 kDa, Purity ≥95% |
| X25-02-ZQ031 |
FITC reagent, Hyaluronic
acid-FITC, HA 20 kDa, Purity ≥95% |
| X25-02-ZQ039 |
Curcumin reagent,
Curcumin-hyaluronic acid, HA 2 kDa, Purity ≥95% |
| X25-02-ZQ040 |
Curcumin reagent,
Curcumin-hyaluronic acid, HA 5 kDa, Purity ≥95% |
| X25-02-ZQ041
|
Curcumin reagent,
Curcumin-hyaluronic acid, HA 10 kDa, Purity ≥95% |
| X25-02-ZQ042
|
Curcumin reagent,
Curcumin-hyaluronic acid, HA 20 kDa, Purity ≥95% |
Xanthan, a microbial polysaccharide, is highly valued for its exceptional rheological properties, making it an
indispensable agent for viscosity modification and stabilization. Our xanthan derivatives offer precisely modified
viscosity, enhanced stability, and improved compatibility across a wide range of formulations. We have successfully
coupled over 100 groups or compounds such as mesylate, cyclodextrin, DBCO, epoxides, linoleic acid, OPSS, TCO, and
DOTA with xanthan to generate various conjugates for different fields.
| Cat. No. |
Product Name |
| X25-02-ZQ2090 |
PAA reagent, PAA-PEG-xanthan, Purity
≥95% |
| X25-02-ZQ2100 |
PEI reagent, PEI-PEG-xanthan, Purity
≥95% |
| X25-02-ZQ2110
|
Hyaluronic acid
reagent, Hyaluronic acid-PEG-xanthan, Purity ≥95% |
| X25-02-ZQ2120 |
Isothiocyanate
reagent, Isothiocyanate-PEG-xanthan, Purity ≥95% |
| X25-02-ZQ2130 |
PtBA reagent, PtBA-PEG-xanthan, Purity
≥95% |
| X25-02-ZQ2140 |
PMMA reagent, PMMA-PEG-xanthan, Purity
≥95% |
| X25-02-ZQ2150 |
PBA reagent, PBA-PEG-xanthan, Purity
≥95% |
| X25-02-ZQ2160 |
DMPE reagent, DMPE-PEG-xanthan, Purity
≥95% |
Publication
DOI: 10.3390/ijms24021040
Journal: International Journal of Molecular Sciences
IF: 4.9
Published: 2023
Results: A new arginine-chitosan (Arg-CS) nanoparticle efficiently delivers siRNA into mouse
leukemia cells. Simply modified from low molecular weight chitosan, FTIR confirmed arginine's covalent
binding. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) identified it as a
nanoparticle, dynamic light scattering (DLS) showing size 75.76 ± 12.07 nm. It encapsulates siRNA via
electrostatic interactions in vitro, with the complex safe for L1210 cells. This first identification
of Arg-CS as a nanoparticle and its Rhoa siRNA delivery in T-cell acute lymphoblastic leukemia cells aims to
advance Rhoa-targeted treatments.
Fig.1
A novel form of arginine-cChitosan nanoparticles. (Luo, et al., 2023)
Applications
- Drug delivery systems: As excipients or active components in targeted drug delivery, controlled release
formulations, and gene therapy vectors.
- Tissue engineering & regenerative medicine: As scaffolds for cell growth, wound dressings, and components in
implants due to their biocompatibility and biodegradability.
- Biopesticides & biofertilizers: Enhancing plant growth and protecting against pathogens.
- Wastewater treatment: As flocculants for pollutant removal.
- Bioremediation: Assisting in the breakdown of environmental contaminants.
Advantages of Us
- Superior quality and purity: Adhering to stringent quality control standards, our products undergo rigorous
testing and characterization. This commitment guarantees exceptional purity, consistency, and performance,
critical for sensitive applications.
- Comprehensive product portfolio: From chitosan to xanthan and their diverse derivatives, our extensive catalog
offers a wide range of options, making CD BioGlyco a single source for all your marine carbohydrate needs.
- Customization at its core: We understand that each project is unique. CD BioGlyco excels in providing bespoke
solutions, tailoring derivative properties such as molecular weight, degree of substitution, and functional groups
to precisely match your application requirements.
Frequently Asked Questions
What are the primary advantages of using marine carbohydrate derivatives over synthetic
polymers in applications?
Marine carbohydrate derivatives have natural origins, good biocompatibility, biodegradability, and unique
biological activities not seen in synthetic polymers. They offer a sustainable, safer option for sensitive
applications, reducing environmental impact and toxicity risks.
Can CD BioGlyco customize the properties of these derivatives, such as molecular weight or
degree of substitution, to fit my specific research needs?
Yes. Customization is key to our service. We tailor molecular weight, substitution degree, and add specific
functional groups to match your application needs. Discuss details with our scientific team.
Contact Us
CD BioGlyco is your trusted partner in exploring marine carbohydrate derivatives. With
high-quality products, expertise, and custom services, we support your projects—whether standard derivatives or
specialized solutions. Contact us to learn more and discuss your project goals.
Associated Services
Reference
- Luo, J.; et al. A novel form of arginine-chitosan as nanoparticles efficient for siRNA delivery into
mouse leukemia cells. International Journal of Molecular Sciences. 2023, 24(2): 1040. (Open
Access)
