Chitooligosaccharide-related Biomarker Development Service

Chitooligosaccharide (COS)-related Biomarker Development Service at CD BioGlyco

COS on Fish and Shellfish Aquaculture

CD BioGlyco works in the Production and Characterization of COS, derived from chitosan, a key derivative of chitin. Chitin, a vital natural polysaccharide, undergoes partial deacetylation to yield chitosan, which is enzymatically or chemically hydrolyzed to produce COS. Known for their enhanced solubility and low viscosity, COS and its derivatives have garnered significant attention from researchers for diverse biomedical applications. At CD BioGlyco, we offer comprehensive COS production and characterization services to cater to various research needs.

Fig.1 The chemical structure of chitin, chitosan, and COS. (Mohan, et al., 2023)

COS-related Biomarkers Development Service

At CD BioGlyco, our research process ensures a thorough investigation of COS for potential biomarker applications, providing clients with valuable insights for their scientific endeavors. Here is our research process for COS-related biomarker development service, we aim to provide high-quality custom development services for our clients.

• Define client objectives and requirements for biomarker development.
• Utilize advanced techniques for efficient COS production to ensure high purity and quality of COS for downstream applications.
• Employ state-of-the-art analytical methods to characterize COS. Assess molecular weight, structural features, and other relevant parameters.
• Explore the potential of COS in biomarker development. Investigate interactions with specific biological targets.
• Conduct in vitro experiments to evaluate the impact of COS on relevant pathways. And also provide in vivo studies to validate biomarker candidates in animal models.
• Analyze data generated from experiments and generate reports.

Fig.2 The research process of COS-related biomarker development. (CD BioGlyco)

Publication

Technology: COS and N-acetylglucosamine (GlcNAc) production, Acid hydrolysis of chitin, Enzymatic conversion

Journal: Frontiers in Chemistry

IF: 5.5

Published: 2020

Results: Efficient large-scale production of COS and GlcNAc with defined properties remains a challenge. Chemical methods produce toxic waste, while enzymatic approaches yield low quantities. A synergistic chemical-enzymatic process and the use of ionic liquids for substrate pretreatment show promise for environmentally friendly production. Further research is needed to optimize chemoenzymatic methods and explore engineering and derivatization strategies to enhance the biological activities of COS and GlcNAc. Detailed molecular investigations are crucial for advancing these processes.

Fig.3 Representation of the mechanism involved in COS and GlcNAc generation through ionic liquid. (Kumar, et al., 2020)

Applications

• Biomedical research
  
  • Identify and characterize COS-related biomarkers associated with specific diseases or conditions.
  • Explore the potential of COS in targeting specific pathways for disease intervention.
  • Develop diagnostic biomarkers for early disease detection using COS-related insights.
• Pharmaceutical development
  
  • Investigate the impact of COS on cellular processes, aiding in the discovery of novel therapeutic agents.
  • Assess the pharmacological properties of COS for potential drug development.
  • Evaluate the safety and compatibility of COS for pharmaceutical applications.

Advantages

• CD BioGlyco not only provides the custom COS-related biomarker development service but also provides COS production and characterization service.
• CD BioGlyco has established a high-level lab that has the ability to provide system development services for clients worldwide.

CD BioGlyco not only provides a COS-related biomarker development service but also provides other marine-derived glycan-related biomarkers development services. Please feel free to contact us if you are interested in our services.