Glycerine-related Biomarker Development Service at CD BioGlyco
Glycerol ether lipids, specifically glycerol dialkyl glycerol tetraethers (GDGTs), typically found in aquatic Archaea microorganisms, are crucial indicators of past environmental conditions, such as water temperature and pH. As the organisms expire, GDGTs morph into core GDGTs, reflecting changes in sea surface temperatures over time - a critical element in climate change conversations. CD BioGlyco offers a compound analysis service that aids in detecting and interpreting these biomarkers, thus contributing to the ever-evolving discussions and strategies surrounding climate change.
Fig.1 (A) General structure of GDGT and (B) glycerol dialkanol diether (GDD) molecules. (Radovic, et al., 2016)
At CD BioGlyco, we provide advanced glycerine-related biomarker development services, supported by our extensive experience and cutting-edge technologies. Glycerol ether lipids, originating from Archaea microorganisms, predominantly consist of GDGTs. These molecules are instrumental in detecting changes in environmental parameters like water temperature and pH. After undergoing degradation and losing their polar head groups, they form core GDGTs. Notably, the dissipation trends of GDGT species in sediments have been widely used in creating proxies for reconstructing past sea surface temperatures. We are adept at facilitating this complex analysis and contributing towards understanding and mitigating climate change intricacies.
Here is our standard analysis for glycerine-related biomarker research.
- Extraction and Purification
Efficient extraction of glycerine-related compounds from biological samples is paramount. CD Biolyco uses suitable solvents and methodologies to ensure optimal recovery. Purification techniques, like chromatography, help isolate target biomarkers, eliminating interfering substances for a more accurate analysis.
- Analytical Method
The heart of biomarker research lies in robust analytical methods. CD BioGlyco employs advanced techniques, such as chromatography coupled with mass spectrometry, which enhances the specificity and sensitivity of detection.
- Biomarker Identification
Identification of glycerine-related biomarkers demands a multifaceted approach. Comparative analyses, potentially against control samples, facilitate the recognition of unique biomolecular patterns. CD BioGlyco uses advanced bioinformatics tools to aid in deciphering the molecular structures and functions of identified biomarkers.
- Based on the initial consultation, a proposal detailing the services, timeline, and cost is prepared and sent to the client for approval.
- Once the proposal is approved, the client should collect and deliver the samples to us.
- CD BioGlyco uses techniques such as mass spectrometry, chromatography, and bioinformatics to identify potential biomarkers in the samples. We also provide other Characterization services according to the client's needs.
- The data obtained from the biomarker identification is analyzed thoroughly.
- CD BioGlyco provides a detailed report of the results, including the potential biomarkers identified, their implications, and suggestions for future work.
Fig.2 The flowchart of glycerine-related biomarker development. (CD BioGlyco)
Publication
Technology: Fourier-transform ion cyclotron resonance-mass spectrometry (FTICR-MS), Nontargeted screening
Journal: Analytical Chemistry
IF: 7.4
Published: 2016
Results: This study explains the development of a FTICR-MS-based method for rapid screening of ether lipid biomarkers in marine sediments. The method simplifies sample preparation, identifies known and novel ether lipid species, and can accurately determine GDGT-based proxy indices. The results show FTICR-MS has potential for not only rapidly determining existing proxy indices, but also as a tool for early detection of new biomarkers and proxies offering insights into environmental, energy, and climate-related variables.
Fig.3 FTICR-MS-based method for rapid screening of ether lipid biomarkers. (Radovic, et al., 2016)
Applications
Our glycerine-related biomarker development service can be used in paleoenvironmental reconstruction, offering insights into past climates and geologies through the analysis of glycerol ether lipids. Other applications include environmental science and healthcare, with the potential for these biomarkers to identify diseases or pollutants.
Advantages
- We have the highly accurate and rapid screening method, its ability to handle a diverse range of species, and its potential for identifying new biomarkers and proxies.
- Our service offers significant potential for understanding key environmental and biological variables that could have impactful applications in climate change discussions and strategies.
At CD BioGlyco, we are proud to offer our glycerine-related biomarker development services. This service utilizes our cutting-edge technology and expertise to identify and analyze glycerine-based biomarkers, which are key in understanding and tracking various biological and environmental processes. This service has applications in fields such as climate change research, environmental studies, and health diagnostics research. Please do not hesitate to contact us for more information if you are interested in our services!
Reference
- Radovic, J.R.; et al. Rapid screening of glycerol ether lipid biomarkers in recent marine sediment using atmospheric pressure photoionization in positive mode Fourier transform ion cyclotron resonance mass spectrometry. Analytical Chemistry. 2016, 88(2): 1128-1137.
