Fucan-related Biomarker Development Service

Fucan-related Biomarker Development Service at CD BioGlyco

Marine-derived Fucan as An Aid for Biomarker Development

Marine organisms are rich sources of potent biomolecules with promising therapeutic and nutraceutical applications. Among these, sulfated fucose-rich polysaccharides such as sulfated fucan (fucoidan or sulfated α-L-fucan) and fucosylated chondroitin sulfate are particularly abundant, showcasing significant pharmacological effects across diverse biological systems. At CD BioGlyco, we provide clients with a range of services including fucan production, Characterization, and related Biomarker Development. Fucan's notable biological activity has attracted attention in potential drug development studies, allowing scientists to explore its associations with disease-related biomarkers and utilize it as a valuable tool in biomarker development during drug discovery.

Biomarker Development Service

At CD BioGlyco, we provide the cutting-edge fucan-related biomarkers development service, designed to advance your research and bring novel insights to your projects. Fucan has many potential biological functions, and in disease research, it affects many biomarkers associated with disease. For example, in the study of diabetes, by feeding model mice, researchers observe changes in the levels of several molecules in the body, including enzymes such as α-amylase and α-glucosidase, as well as probiotic bacteria and insulin resistance. Here is the standard process of our fucan-related biomarker development service.

• Identification of candidate biomarkers: Begin by identifying potential biomarkers related to fucans.
• Experimental validation: Conduct experimental studies to validate the association between fucans and the identified biomarkers.
• Biospecimen collection: Collect relevant biospecimens, such as blood, urine, or tissue samples, from individuals under study.
• Biomarker measurement: Develop or utilize assays and techniques to accurately measure the levels or activity of the selected biomarkers in collected biospecimens.
• Data analysis: Analyze the data obtained from biomarker measurements.
• Validation studies: Validate the identified biomarkers in larger and more diverse cohorts to ensure the robustness and generalizability of the findings.

Fig.1 Flowchart of fucan-related biomarker development. (CD BioGlyco)

Publication

Technology: Regulation of PI3K-Akt signaling pathway, Inhibit enzyme activity

Journal: Foods

IF: 5.2

Published: 2023

Results: Current studies on the hypoglycemic activity of brown algae polysaccharides focus on species like Sargassum pallidum, Sargassum fusiform, and Undaria pinnatifida. Fucoidan (FU) extracted from them, specifically SPP-1, PSP-1, SFP-2, SFF, SFP-7-40, LMWF, UP4, UPP, Ecklonia maxima, Macrocystis pyrifera, Dictyopteris divaricata, Laminaria japonica, and others, exhibits significant hypoglycemic effects in vitro and in vivo. Polysaccharides from red algae, green algae (Ulva lactuca), and microalgae (Spirulina platensis) also demonstrate hypoglycemic activities. Marine fucosyl-polysaccharides from sea cucumbers, including sulfated fucan (SC-FUC) and fucosylated chondroitin sulfate (SC-FCS), exhibit hypoglycemic effects, especially in low-edible-value sea cucumbers.

Fig.2 Structure of marine fucosyl-polysaccharides from brown algae and sea cucumber. (Tang, et al., 2023)

Applications

Sulfated fucans, characterized by their distinctive sulfation patterns and inherent biological activities, not only function as potential biomarkers but also contribute significantly to medical research. The exploration of sulfated fucans unveils opportunities to discover novel biomarkers associated with diverse diseases and conditions. This, in turn, plays a pivotal role in advancing early detection methodologies, refining diagnostic approaches research, and enhancing treatment monitoring strategies across a spectrum of medical scenarios.

Advantages

• We have a well-equipped laboratory offering a range of marine carbohydrates, as well as various other Marine Biomolecules, facilitating comprehensive research in the field of marine sugars.
• Our team of experienced scientists, equipped with extensive expertise, collaborates closely to deliver tailored solutions for biomarker studies.
• Our professional R&D team ensures efficient and precise experiment execution, leading to high-quality research results for our clients.

With a wealth of research expertise in glycan studies, CD BioGlyco offers specialized and customizable fucan-related biomarker development services through our dedicated R&D team, catering to the unique needs of our clients. Please feel free to contact us for more information if you are interested in our services.