Provide High-quality and Efficient Services for Clients on the Pragmatic, Honest Principle
Glycomimetics are mimics of Carbohydrate Structure and function that act by replacing the natural ligands during recognition binding to the target protein. The design of glycomimetics enhances enzyme stability and bioavailability and increases affinity and selectivity for the target protein. At CD BioGlyco, our professional team of scientists manipulates the chemical information encoded by Marine Carbohydrates by adjusting (controlling and changing) the information they guide.
The design of marine carbohydrate mimetics is currently considered an effective alternative to developing therapeutic agents. We improve the properties of analogous drugs by starting with structural analysis of natural carbohydrate substrates bound to protein targets that stabilize their bioactive conformation and remove unwanted functional groups. The high-value conversion of marine carbohydrates mainly refers to its application in drugs, food, and cosmetics. Our scientists help you maximize the role of marine carbohydrates. Notably, we also provide high-targeting Drug-Delivery Vehicle, Vaccine, and Adjuvant development services based on marine carbohydrate.
Fig.1 Flowchart of marine carbohydrate mimetic development service. (CD BioGlyco)
Marine Carbohydrate Mimetic Development Service at CD BioGlyco
With a special focus on the design and synthesis of carbohydrate mimics, CD BioGlyco provides a one-stop service for developing marine carbohydrate mimetics.
- Rapid synthesis of glycomimetics: Our researchers synthesize carbohydrate mimics by semisynthetic/synthetic or assembly based on molecular characteristics. Furthermore, we provide modification services in specific locations.
- Functional characterization and activity test service: Combining multiple analytical tools such as crystallography, nuclear magnetic resonance (NMR) spectroscopy, and other biophysical methods (e.g., surface plasmon resonance and Carbohydrate Microarray), we offer services to analyze key interactions between carbohydrates and their protein targets.
Sulfated fucan-based mimetics consist of sulfated L-fucose. It has a superior ability to induce platelet activation. CD BioGlyco provides sulfated fucan-based mimetic preparation and analysis services such as biparental nuclear replacement synthesis by using several technical routes.
Sulfated galactan-based mimetics contain variable sulfation patterns and 2,3-O-sulfated D-galactose residues. It has an anticoagulant and antithrombotic activity. CD BioGlyco offers comprehensive sulfated galactan-based mimetics development services from design and synthesis to drug applications.
CD BioGlyco has accurate synthesis strategies for heparin-based mimetic and provide clients with enzymatic elongation and chemical sulfation for modification. The mimetics such as di-, tri-, or tetrasaccharides. Furthermore, we evaluate the interaction of the mimetics with the receptor of higher glycation end products.
CD BioGlyco has a strategy for the design and synthesis of alginate-based mimetics with rich and diverse biological activities. It is formed by β-D-mannose and α-L-aldehyde acid through 1,4 linked glycosidic bonds. In addition, our professional analysis team provides follow-up analysis identification and drug development services.
Hyaluronic acid (HA) is a key element of the extracellular matrix (ECM). CD BioGlyco provides HA-based biomaterials as targeted delivery systems and ECM mimetics development services. In the presence of 2D and 3D models, we analyze HA particles as active targeting of drug/protein carriers.
Publication
Technology: Nuclear magnetic resonance, Electrospray ionization mass spectrometry
Journal: Communications Chemistry
IF: 6.681
Published: 2021
Results: A flexible and versatile diversity-oriented synthesis method was developed in this study. We used a one-pot-catalyzed aldehyde α-functionalization/aldol reaction to generate a series of stereochemically well-defined glycomimetic building blocks. These compounds have good yields and excellent diastereomer enantioselectivity. This simple method quickly and accurately generates large libraries of glycomimetics.
Fig.2 Synthesis of glycomimetics. (Meanwell, et al., 2021)
Applications of Marine Carbohydrate Mimetic
- Marine algae and invertebrate polysaccharide mimetics is an effective tool for elucidating the structural/anticoagulant activity relationship.
- Structurally and functionally highly diverse marine carbohydrate mimetics synthesized by polymerization techniques play an important role in studying the cellular and intracellular responses to platelet activation.
- Sulcanated HA mimetics combined with heparin and epidermal growth factor heal wounds.
- Marine carbohydrate mimetics provides new molecular probes for carbohydrate-mediated recognition and protein transport to explore complex biological mechanisms.
- Marine carbohydrate mimetics as a potential tool expands the translation of the bioactivity of carbohydrates into therapeutic applications.
Advantages of Us
- Our researchers start with the design and synthetic carbohydrate mimics by analyzing the structure of natural carbohydrate substrates bound to protein targets. This stabilizes bioactivity conception and avoids unnecessary involvement of functional groups.
- The synthetic services we provide include a wider range of electrophiles and enolizable ketones, supporting the construction of different carbohydrate mimics.
CD BioGlyco provides comprehensive Marine Biomolecule Production services to clients. We have an experienced technical team and diverse glycobiology platforms to meet the requirements of our clients. In addition, we offer professional Marine Carbohydrate-related Biomarker and Biomaterial Engineering Development services. Please feel free to contact us.
References
- Li, X.; et al. Recent advances in the chemical synthesis of marine acidic carbohydrates. Current Organic Chemistry. 2021, 25(4): 507-518.
- Compain, P. Glycomimetics: design, synthesis, and therapeutic applications. Molecules. 2018, 23(7): 1658.
- Meanwell, M.; et al. Diversity-oriented synthesis of glycomimetics. Commun Chem. 2021, 4(1): 96.
