Marine Peptidoglycan-based Biomaterial Engineering Development Service at CD BioGlyco
CD BioGlyco has extensively focused on and researched the use of Marine Carbohydrates (Hemicellulose, Xylan, Heparan Sulfate, marine peptidoglycan, etc.) in regenerative medicine, the food industry, biosensors, and therapeutics. Marine peptidoglycan is found in the cell walls of certain marine bacteria. It is a complex polysaccharide responsible for resisting environmental stresses and maintaining the structural integrity of bacteria. We provide a marine peptidoglycan-based biomaterial engineering development service to meet the needs of our clients for different applications.
Fig.1 Marine peptidoglycan-based biomaterial engineering development service. (CD BioGlyco)
Application-based Engineering Development of Marine Peptidoglycan-based Biomaterials
We develop biomaterials with good performance based on the unique properties of peptidoglycan for our clients' different research.
Scaffold materials
Scaffolds prepared from marine peptidoglycan act by mimicking the properties and structure of tissues. We engineer the structure and composition of marine peptidoglycan-based scaffolds. By optimizing their porosity, mechanical strength, and degradation rate to meet the requirements of specific tissues.
Drug delivery system
Marine peptidoglycan is a good candidate for targeted drug delivery. Hydrogels or nanoparticles prepared from marine peptidoglycan are an effective drug delivery carrier. Based on the unique structure of peptidoglycan, the prepared hydrogels or nanoparticles are used to control drug release.
Anti-adhesive coatings
Marine peptidoglycan is used for surface modification or development of anti-biofilm coatings. Prevention of biofilm and bacterial adhesion formation on surfaces such as medical devices is achieved by coating or adding marine peptidoglycan or its derivatives to the surface. This approach is used to improve the performance and service life of these materials.
Other applications
We also develop marine peptidoglycan-based biomaterials for use as wound aids and regenerative medicine.
Chemical Modification
The structure of marine peptidoglycan consists of short peptide chains cross-linked with repeating sugar units. The peptide chains are composed of various amino acids, the exact composition of which varies depending on the bacterial species. The sugar units usually include N-acetylmuramic acid and N-acetylglucosamine. We utilize Chemical Modification of marine peptidoglycan. By modifying marine peptidoglycan or its derivatives, it is possible to develop novel materials with unique properties for drug delivery systems, tissue engineering, and other biotechnology applications.
Publication Data
Technology: Chemical modification
Journal: Engineered Biomaterials
Published: 2023
Results: This paper points out the potential uses of peptidoglycan. Peptidoglycan can be used as a scaffold for cell development in tissue engineering to promote the regeneration of damaged tissues. Peptidoglycan also has the potential to be used as an antimicrobial material for the manufacture of coatings for medical devices or implants, thus preventing bacterial colonization and biofilm formation.
Applications
- Marine peptidoglycan-based scaffolds provide support structures for tissue regeneration, cell proliferation, and adhesion.
- Marine peptidoglycan-based biomaterials are used to enhance drug bioavailability and provide sustained release profiles.
- Marine peptidoglycan stimulates cell migration, promotes tissue regeneration, and modulates immune responses. It has potential applications in promoting wound healing. Marine peptidoglycan-based materials are used as scaffolds or wound dressings to improve the therapeutic efficacy of various types of wounds and accelerate the healing process.
Highlights of Us
- We utilize the unique properties of marine peptidoglycan to develop innovative biomaterials for various applications.
- We use chemical methods to synthesize structurally diverse marine peptidoglycan derivatives. Chemical modifications are expected to produce derivatives with favorable properties, which are essential for processes such as tissue regeneration.
- We combine several interdisciplinary approaches to design and prepare marine peptidoglycan-based biomaterials.
At CD BioGlyco, our goal is to develop biomaterials with good specificity, selectivity, biocompatibility, and thermal stability. We prepare various types of marine peptidoglycan-based biomaterials for different research purposes according to client requirements. Please feel free to contact us with your needs for biomaterial development. We will complete all experiments from design, optimization, and preparation to testing.
References
- Irazoki, O.; et al. Peptidoglycan muropeptides: release, perception, and functions as signaling molecules. Frontiers in microbiology. 2019: 10: 500.
- Jasni, A.H.; et al. Naturally derived biomaterials: advances and opportunities. Engineered Biomaterials. 2023, 3-41.
- Garde, S.; et al. Peptidoglycan: structure, synthesis, and regulation. EcoSal Plus. 2021, 9(2).
