Enhancing Carbohydrates with Precursor Precision
Marine carbohydrates are an important class of active substances with abundant physiological activity and strong hydrophilic properties. CD BioGlyco has mastered a wide range of Technologies for the Production of Marine Carbohydrates and has accumulated deep experience in the field of Marine Carbohydrate Production.
Here, we regulate the process of carbohydrate production by modifying precursor molecules found in marine sources, thus realizing targeted production of carbohydrates. Among them, precursor molecules of marine origin include but are not limited to, monosaccharides, polysaccharides, oligosaccharides, lipids, glycosides, and lectins, among others.
Chemical modification of precursor molecules
Chemical modification is a common method to achieve structural modification of compounds. We offer a wide range of chemical modifications for precursor molecules of marine origin, such as Schiff base reactions, quaternization, carboxymethylation, acylation, silylation, and coupling reactions.
Using chemical modifications, we achieve backbone modification of precursor molecules. For example, the removal of polar groups or the addition of non-polar groups to precursor molecules can effectively increase the cell permeability of subsequently produced carbohydrates, thus laying the foundation for their use in pharmaceutical research and development. In addition, for some precursor molecules containing large groups, the substitution reaction of small groups can reduce their size and make it have the nature of small molecules.
Enzymatic modification of precursor molecules
Enzymatic modification is a gentle and environmentally friendly approach. We screen enzymes that modify precursor molecules based on the specificity of the particular enzyme to catalyze the production of carbohydrates from precursor molecules of marine origin. The enzymes we commonly use include glycosidases and glycosyltransferases.
We use specific enzymes to perform different structural modifications on marine-derived precursor molecules, such as acetylation, deacetylation, and so on. Such modifications alter the physicochemical and biological properties of the precursor molecules and provide the prerequisite for functional changes in the subsequently produced carbohydrates.
Carbohydrate production
Based on the modification of precursor molecules, we provide chemical and biological methods for the synthesis of target carbohydrates.
- Chemical synthesis method: We use differently modified precursor molecules as substrates to synthesize target carbohydrates. In this process, we offer a one-pot synthesis strategy, a solid-phase synthesis strategy, and so on.
- Biosynthesis: We provide an enzymatic modular assembly strategy and enzymatic isomerization strategy to achieve precise synthesis from marine-derived precursor molecules to target carbohydrates.
After obtaining the target carbohydrates, we also provide Carbohydrate Purification and Characterization Services to further ensure that our client's research needs are met. Examples include chromatography techniques, and nuclear magnetic resonance (NMR) and infrared (IR) techniques.
Applications
- The addition of functional groups with pharmacological properties to precursor molecules of marine origin can be used to produce pharmacologically active carbohydrate molecules for drug discovery.
- Modification of marine-derived precursor molecules can be used to produce biologically active carbohydrates that can be used in the preparation of green biomaterials.
- In agriculture, targeted modification of marine-derived precursor molecules can be used to produce carbohydrates that enhance plant production, which can be used to develop biopesticides to improve crop yields.
Advantages
- We have accumulated profound experience in the production of marine biomolecules, and we offer targeted production of marine carbohydrates using precursor modification technology while meeting the needs of a wide range of fields, including scientific research institutes, pharmaceutical companies, and the food industry.
- We have been in the research of marine carbohydrates for a long time, providing and developing new and modified marine carbohydrate products for our clients.
- We provide custom production solutions for marine carbohydrates according to our client's project needs and provide them with detailed results of marine carbohydrate characterization.
Frequently Asked Questions
What are the key points to keep in mind during the production of marine carbohydrates by precursor modification?
Precursor selection and optimization: There is a need to select suitable precursor substances, which must be able to be efficiently converted to the target carbohydrates. At the same time, some of the precursors may be difficult or costly to obtain, which can limit large-scale production.
Control of biocatalytic reaction conditions: Marine-derived precursor molecules are demanding in terms of environmental conditions (e.g., temperature, pH, oxygen content, etc.) and must be precisely controlled to optimize production efficiency.
What are the advantages of utilizing precursor modification for marine carbohydrate production?
Efficiency: The efficiency of carbohydrate production can be improved by modifying the precursor.
Controllability: Precursor modification technology allows for fine control of the synthetic pathway and therefore better control of the structure and properties of the final product.
Environmentally friendly: This method reduces by-products in chemical synthesis and lowers environmental pollution.
Versatility and functionality: Marine carbohydrates can be synthesized with specific functions or biological activities, which has a wide range of applications in fields such as medicine, food science, and materials science.
With a dedicated team of marine carbohydrates researchers, CD BioGlyco offers clients client solutions for the production of carbohydrates using precursor modifications. With our leading technology advantage and rich industry experience, we ensure an efficient and sustainable production process to meet the diverse needs of our clients. We sincerely welcome clients to contact us to discuss customized marine carbohydrate solutions for a win-win situation.
Reference
- Vasconcelos, A.A.; Pomin, V.H. Marine carbohydrate-based compounds with medicinal properties. Marine Drugs. 2018, 16(7): 233.
