Highly Efficient Production of Aminoglycoglycerolipids in a Strict Systematic Approach
The deep sea contains various biological resources, and CD BioGlyco provides our clients with specialized Marine Biomolecule Production solutions. Marine Glycoglycerolipid refers to Marine Glycolipid compounds extracted and refined from marine organisms, which play an important ecological role in the marine environment. We also provide other types of marine glycolipids such as Marine Glycosphingolipid Production and Marine Atypical Glycolipid Production services. With the help of advanced extraction technology, our researchers efficiently extract, isolate, and purify aminoglycoglycerolipid from marine samples.
Pre-treatment of Marine Alga
The collection and pre-processing of marine algae is a crucial first step. Our biologists delicately collect algae samples using manual or mechanical methods to minimize external contamination and damage. The collected algae are initially cleaned to remove adhering sandy sediments and other impurities. Next, the algae samples are cut or ground to prepare them for chemical extraction.
Extraction and Purification of Aminoglycoglycerolipid
- Organic solvent extraction
We use a methanol aqueous solution and n-butanol to extract the target from the algae. After repeated leaching, our researchers collect the n-butanol fraction for subsequent purification and discard the methanol aqueous solution.
- Purification
Our lab provides high-quality purification services by combining Sephadex and reversed-phase silica gel column chromatography. We adjust the pH of the mobile phase for optimal separation.
Characterization of Aminoglycoglycerolipid
Due to its structural complexity and diversity, we use rigorous identification services to determine the molecular structure of aminoglycoglycerolipid. We deliver analytical reports that include matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) data, nuclear magnetic resonance (NMR) data, gas chromatography-mass spectrometry (GC-MS) data, acyl groups sites, molecular weight, and molecular composition.
Applications
- Anti-cancer activity: Aminoglycoglycerolipid has strong biological activity potentially attractive in the treatment of cancer. For example, it can be used to develop novel Myt1 kinase glycolipid inhibitors.
- Drug discovery: Aminoglycoglycerolipid provides a new point of exploration for marine glycoglycerolipid drug discovery.
- Anti-viral activity: Aminoglycoglycerolipid has significant inhibitory activity against influenza A virus (IAV). Aminoglycoglycerolipid analog has a blocking effect on viral replication in cells. It can be used for the proliferation inhibition of IAV.
Advantages of Us
- CD BioGlyco pays extra attention to the entire collection and fragmentation process to keep the chemical composition of the algae as intact as possible while minimizing impurities in the samples to ensure the accuracy and reproducibility of the final results.
- Our researchers rapidly place the collected algae samples in a refrigerated environment to inhibit enzymatic and microbial breakdown.
- Our researchers have proven data parsing experience in structural characterization, helping clients complete sample analysis quickly and accurately.
Frequently Asked Questions
What are some of the glycerolipids isolated from marine microalgae?
Glycerolipids isolated from marine microalgae can be classified into two main groups:
- Fungal glycoglycerolipids: Fungal glycoglycerolipids are mainly diacylglycerol lipids, monoacylglycerol lipids, and dialkylglycerol lipids. The glycosyl fraction is mainly monosaccharides, disaccharides and trisaccharides
- Protist-bacteria glycoglycerolipids: The structure of protist-bacteria glycoglycerolipids is characterized by a D-galactofuranose residue attached to a tetraether lipids which consists of a 36- or 72-membered macrocycle containing two glycerol groups and two long-chain alkyl groups.
What is the biological activity of aminoglycoglycerolipids?
Aminoglycoglycerolipids have a variety of compelling biological activities such as antimicrobial, antitumor, antiviral, against Leishmania donovani, antidepressant, and others.
CD BioGlyco offers high-yield production of aminoglycoglycerolipids derived from marine alga. Not only that, if clients are interested in custom aminoglycoglycerolipid synthesis, our professional synthesis team provides efficient molecular design and synthesis services for you. Our goal is to fulfill all of our client's needs in the production of marine molecules. Feel free to contact us for more information.
