Your Best Partner for Myrmekioside Production
Ocean resources are unfathomable and marine molecules are highly biologically active. With superior extraction and purification technologies, CD BioGlyco provides our clients with reassuring Marine Biomolecule Production services worldwide. Whether you need Marine Carbohydrates or Marine Glycolipids, our highly trained production team is ready for anything. Myrmekioside is a Marine Glycoglycerolipid from a marine sponge of Myrmekiodema sp. Relying on experienced researchers, we provide our clients with high-purity and many types of myrmekioside production services.
Pretreatment of Raw Materials
We use the marine sponge of Myrmekiodema sp. as raw material for extraction. We provide professional pre-treatment services for the collected marine sponge, including cleaning, chopping, and freezing services.
Extraction and Purification
We use acetone to extract the collected sponges at room temperature for 12h and repeated three times. The residue obtained by evaporation of the solvent under reduced pressure is partitioned into an AcOEt-water mixture. The water phase is further extracted using n-BuOH to obtain the n-BuOH soluble fraction. For the AcOEt-soluble fraction, we use repeated SiO2 column chromatography for separation.
The target components are mainly present in the n-BuOH soluble fraction. For the n-BuOH soluble fraction, our researchers provide efficient separation service by repeated SiO2 column chromatography and octadecyl silyl high-performance liquid chromatography (ODS-HPLC).
For the purification of the obtained fractions, our lab provides a comprehensive characterization service to ensure the quality of the product.
- Gas-liquid chromatography (GLC)
- Mass spectrometry (MS)
- Nuclear magnetic resonance (NMR)
- Infrared (IR) spectroscopy
- HPLC
Bioassay
Bioactive molecule detection is an essential step in the production, we mainly provide anti-cancer activity assay, cell cycle assay, flow cytometry analysis, etc.
Publication Data
Journal: Marine Drugs
Published: 2016
IF: 4.9
Results: In this work, the scholars discuss surfactants and anticancer active molecules isolated from the marine. Among them, myrmekioside is a glycolipid isolated from sponges, and its derivatives were shown to have anticancer activity against human non-small cell lung cancer cells.
Fig.1 Anti-cancer effects of biosurfactants and design of therapeutics. (Gudiña, et al., 2016)
Applications
- Myrmekioside can be used as a selective inhibitor of the function of activated ras oncogene.
- Myrmekioside has immunomodulatory effects and antitumor activity and plays an important role in fibroblast recognition and antigen-specific recognition.
- In-depth development of myrmekioside and its derivatives facilitates the discovery of novel anticancer drugs.
Advantages of Us
- Relying on a well-established quality testing system, our researchers strictly test all the active components obtained from the isolation to ensure that the quality is up to standard.
- Our researchers have accumulated mature operational experience in organic solvent extraction and chromatographic separation, and we strictly adhere to each index.
- Our highly trained glycolipid production team provides efficient myrmekioside production solutions to ensure the delivery of high-quality, high-purity, and high-activity products.
Frequently Asked Questions
What types of myrmekioside are available from CD BioGlyco?
CD BioGlyco provides high-purity myrmekiosides include myrmekioside A, myrmekioside B, myrmekioside C, myrmekioside D, myrmekioside E, myrmekioside E-1, myrmekioside E-2, myrmekioside E-3.
What are the biological properties of myrmekioside and its derivatives?
Myrmekioside and its derivatives have antitumor activity, immunomodulatory effects, antiproliferative activity, etc. Above all, it is active against tumor cells and inactive against normal cells.
CD BioGlyco continues to develop marine resources for the full exploitation of marine glycolipids. Combining various technologies, we offer our clients satisfactory solutions for myrmekioside production. Whether you are interested in myrmekioside extraction and separation or myrmekioside synthesis, please feel free to contact us.
Reference
- Gudiña, E.J.; et al. Biosurfactants produced by marine microorganisms with therapeutic applications. Marine Drugs. 2016, 14(2): 38.
