Metabolism Regulation Seaweed Oligosaccharide Ingredient Production Service

Home
Services
Marine Biomolecule Production Service
Industrial-grade Seaweed Oligosaccharide Ingredient Production
Biopharma-grade Seaweed Oligosaccharide Ingredient Production
Metabolism Regulation

Metabolism Regulation Seaweed Oligosaccharide Ingredient Production Service

The global challenge posed by metabolic syndrome, characterized by obesity, dyslipidemia, and insulin resistance, demands innovative therapeutic and nutritional interventions. Seaweed oligosaccharides represent a frontier in natural bioactive compounds, offering potent regulatory effects superior to their parent polysaccharides due to enhanced bioavailability and intestinal absorption. CD BioGlyco specializes in the custom, large-scale production of high-purity, structurally defined seaweed oligosaccharide ingredients designed explicitly for functional food, nutraceutical, and pharmaceutical development focused on metabolic health. Leveraging decades of expertise in glycobiology, our service provides partners with the critical, high-quality material required to accelerate their R&D pipelines.

Key Technologies

Enzymatic Hydrolysis Libraries

We utilize an extensive, in-house library of highly specific marine-derived glycoside hydrolases (e.g., alginases, fucoidanases, carrageenases). These tailored enzymes allow for the precise and controlled depolymerization of complex seaweed polysaccharides, ensuring the resulting oligosaccharides possess a narrow and defined molecular weight distribution, which is crucial for predictable biological activity, such as improved cholesterol reduction or gut microbiota modulation.

Advanced Separation and Purification

Achieving the pharmaceutical-grade purity required for drug development and high-end nutraceuticals demands sophisticated downstream processing. Our infrastructure incorporates state-of-the-art separation techniques, coupled with preparative chromatography (such as ion-exchange and size-exclusion chromatography). These integrated methods guarantee the removal of residual proteins, salts, and unreacted polymers, yielding products with purity exceeding typical industry standards.

Precision Seaweed Oligosaccharide Production for Tomorrow's Health Solutions

This service is engineered to produce seaweed oligosaccharide ingredients that are highly effective in addressing key facets of metabolic dysregulation. Our focus is on low-molecular-weight derivatives known to possess superior bioactivity. These distinct, structurally defined oligosaccharide ingredients are ideal starting points for functional ingredients targeting weight loss, lipid reduction, and glycemic control.

Type	Source	Metabolic Regulatory Effect	Drug Development Potential
Alginate oligosaccharides	Brown Algae	Low-density lipoprotein cholesterol (LDL-C) and total cholesterol reduction, fat absorption inhibition, and satiety promotion.	Anti-obesity agents, appetite regulators, and hyperlipidemia therapeutics.
Fucoidan oligosaccharides	Brown Algae	Improved glucose tolerance, enhanced insulin sensitivity, and anti-inflammatory actions targeting chronic low-grade inflammation.	Anti-diabetic ingredients, AMPK pathway modulators.
Carrageenan oligosaccharides	Red Algae	Modulates gut microbiota composition, increasing beneficial bacteria (e.g., Akkermansia) and short-chain fatty acid (SCFA) production, benefiting lipid and glucose metabolism.	Prebiotic therapeutics for weight management and gut health.
Ulvan oligosaccharides	Green Algae	Anti-obesity and lipid-lowering through potential inhibition of lipogenesis and improved liver health.	Liver support supplements and next-generation functional foods.

Workflow

Workflow for metabolism regulation seaweed oligosaccharide ingredient production.

Publication Data

DoI: 10.3390/md17090540

Journal: Marine drugs

IF: 5.4

Published: 2019

Results: This study explores the anti-obesity effects of unsaturated alginate oligosaccharides (UAOS)—enzymatically derived from Laminaria japonica alginate—in high-fat diet (HFD)-fed KM mice, with acid-hydrolyzed saturated alginate oligosaccharides (SAOS), chitooligosaccharides (COS), and orlistat as controls. UAOS showed dose-dependent anti-obesity effects: unlike ineffective SAOS, UAOS reduced HFD-induced body weight gain, Lee's index, and adipose tissue mass, shrank adipocytes, and improved lipid metabolism. It also alleviated hepatic steatosis and mitigated oxidative stress via its antioxidant property. Mechanistically, UAOS activated the AMPK signaling pathway by increasing AMP-activated protein kinase α (AMPKα) and acetyl-CoA carboxylase (ACC) phosphorylation in adipose tissue, regulating lipid catabolism. Notably, M/G unit structural differences did not affect UAOS' efficacy. As a safe, green agent, UAOS is promising for adjuvant therapy of obesity and related metabolic diseases.

Fig.1 UAOS activated the AMPK signaling pathway in white adipose tissues (WAT). (Li, et al., 2019)

Applications

Weight Management and Anti-Obesity

Seaweed oligosaccharides, particularly certain alginate and fucoidan oligosaccharides, serve as highly effective ingredients for weight control. They function by promoting satiety and potentially inhibiting the absorption of dietary fats by binding to lipids in the gut.

Dyslipidemia and Cardiovascular Health

Specific seaweed oligosaccharides, such as carrageenan oligosaccharides, are known to interfere with cholesterol absorption and excretion mechanisms, contributing to a measurable reduction in circulating lipid levels.

Glycemic Control and Anti-Diabetic Potential

Oligosaccharides can act as α-glucosidase and α-amylase inhibitors, slowing down the digestion and absorption of carbohydrates, thereby mitigating post-prandial blood glucose spikes.

Advantages

Unmatched Structural Precision

Our ability to tightly control the degree of polymerization (DP) and sulfation enables the creation of oligosaccharides with optimized bioactivity, a critical factor often overlooked by standard hydrolysis methods.

Proprietary Enzyme Arsenal

We employ exclusive, highly specific enzymes for depolymerization, providing access to novel oligosaccharide structures that are not commercially available elsewhere, securing intellectual property for your end-product.

Scalability from Bench to Market

Our facilities are equipped for rapid, seamless scale-up from milligram R&D quantities to metric tons of material, eliminating technical hurdles during commercialization.

Frequently Asked Questions

Can you produce specific oligosaccharide monomers or fractions, not just a mixture?

Absolutely. Using advanced preparative chromatography and proprietary fractionation techniques, we can isolate and purify specific oligosaccharide fractions to a very tight DP range, meeting the exact structural requirements for your R&D.

What level of structural data do you provide for the final ingredient?

We provide a Certificate of Analysis (CoA) including nuclear magnetic resonance (NMR) spectra for linkage confirmation, high-pressure size exclusion chromatography (HPSEC) for molecular weight distribution, and quantitative data on sulfation and purity, giving you complete confidence in the material.

We are developing a combination therapy. Can your oligosaccharides be modified for conjugation?

Absolutely. We frequently perform chemical modifications and functionalization of oligosaccharides. Let us know your conjugation chemistry requirements, and we can prepare the material accordingly.

Customer Review

"We required a highly purified and specific Carrageenan oligosaccharide fraction for an inflammatory bowel disease drug candidate. The level of analytical support and documentation provided by CD BioGlyco was first-rate, meeting our rigorous pharmaceutical standards."

-Asia, Quality Assurance Lead

"The quality and consistency of the fucoidan oligosaccharide ingredient we received from CD BioGlyco were exceptional. Their precision enzymatic hydrolysis yielded a material with a DP range tighter than anything else we tested, which translated directly into superior results in our anti-diabetic animal model."

-Amy, Senior Research Scientist

"Working with CD BioGlyco was a genuinely collaborative experience. The seamless scale-up from pilot batch to commercial tonnage was handled flawlessly, adhering to a very demanding timeline."

-Jim, Manufacturing Manager

Associated Services

Marine Glycan Characterization Service

(AI-CD BioGlyco)

Marine Glycoconjugate Development

(AI-CD BioGlyco)

Drug-Delivery Vehicle Development

(AI-CD BioGlyco)

CD BioGlyco stands as the authoritative partner for the custom production of metabolism regulation seaweed oligosaccharide ingredients. Our expert scientific team is ready to discuss your specific targets—whether it's anti-obesity, lipid reduction, or anti-tumor research—and design a bespoke oligosaccharide production strategy. Please feel free to contact us to discuss your project.

Reference

Li, S.; et al. Efficiently anti-obesity effects of unsaturated alginate oligosaccharides (UAOS) in high-fat diet (HFD)-fed mice. Marine drugs. 2019, 17(9): 540. (Open Access)

For research use only. Not intended for any clinical use.

Related Services