Transforming Efficiency Through Fucan Production
Fucan is a sulfated polysaccharide derived from brown algae that has a wide range of biological activities, including anti-inflammatory effects that may help prevent tissue damage caused by excessive inflammation. CD BioGlyco offers professional Marine Plant Polysaccharide Production Services utilizing advanced Technologies for Marine Carbohydrate Production, encompassing a wide range of marine plant polysaccharides such as Alginate, Fucoidan, Laminarin, and fucan.
Acid-base extraction
Our experts utilize dilute acids or bases to treat the brown algae while controlling temperature and time to prevent polysaccharide degradation. During the treatment, they precisely regulate the reaction conditions to ensure maximum extraction of fucan from the brown algae. Next, the neutralization reaction is followed by filtration, centrifugation, washing, and concentration steps to remove impurities and purify the fucan.
Enzymatic Extraction
We prepare a suspension by drying and pulverizing brown algae into powder, then adding it to an appropriate amount of distilled water at a ratio of 10-20 times the volume. Next, we add an appropriate amount of enzyme preparation to the suspension based on specific conditions, the enzymes we typically use are cellulase or pectinase. The enzymatic reaction is conducted at optimal temperature and pH to ensure maximum activity and efficiency, with intermittent stirring to promote full contact between the enzyme and brown algae powder. After completion of enzymatic digestion, the digest is heated to inactivate the enzyme and facilitate fucan solubilization. Finally, insoluble impurities are removed through filtration to obtain a clarified fucan solution, which undergoes concentration, precipitation, washing, and drying steps.
Ultrasound-assisted extraction (UAE)
Typically, we prepare a suspension by initially drying and pulverizing the brown algae into powder, followed by adding the brown algae powder to an appropriate amount of solvent. The next step involves placing the suspension into ultrasonic treatment equipment and optimizing the temperature and ultrasonic power based on specific equipment and experimental conditions. Finally, we obtain a high-purity fucan product through subsequent purification steps.
Publication
Technology: Fucan extraction and cell migration assessment
Journal: Marine Drugs
IF: 5.4
Published: 2023
Results: This article investigated the anti-inflammatory activity of fucan from the brown alga Spatoglossum schröederi in a mouse model of systemic inflammation. Fucan was extracted from the brown alga S. schröederi using an organic solvent. The fucan was found to inhibit leukocyte migration induced by zymosan and reduce weight loss. In addition, the fucan was able to reduce leukocyte migration and interleukin-6 (IL-6) levels and was found to have a protective effect on the liver, reducing liver damage and hepatic aminotransferase levels. Fucan also inhibits cell migration by binding to cell adhesion molecules. It has also been found that fucan reduces the migration of polymorphonuclear leukocytes (PMN), thereby reducing tissue damage. In addition, fucan reduces the production of inflammatory mediators and decreases tissue damage. In conclusion, fucan from S. schröederi has potential anti-inflammatory and hepatoprotective effects and may be a potential resource for the study of severe inflammatory diseases.
Fig.1 Impact of administering fucan derived from S. schröederi on systemic toxicity in the ZIGI murine model. (Silva, et al., 2023)
Applications
- Fucan is utilized in studies related to anticoagulant activity due to its low molecular weight and sulfate-rich structure. It selectively inhibits the activity of endogenous coagulation factor Xase complex.
- Fucan can be used in the preparation of antitumor drugs, antiviral drugs, and intestinal flora regulators.
- Fucan is widely used in skincare products for its ability to promote skin cell growth and repair, improve skin moisturization, and antioxidant, and anti-aging properties.
Advantages
- Our extraction technology can effectively retain the biological activity and functionality of the original fucan so that the extracted fucan has a better effect and activity in subsequent applications.
- The products we get with advanced extraction techniques are of higher quality and purity, which helps to improve the stability and effectiveness of the product.
- We tailor our products to specific requirements and conduct structural and functional modification of fucan through variations in extraction methods and purification techniques.
Frequently Asked Questions
What seaweeds are available to extract fucan?
Fucan is a polysaccharide compound found in seaweed that can be extracted from different types of seaweed through extraction techniques. Some common seaweeds from which fucan can be extracted include kelp, sea vegetables, and other brown algae.
How to choose the suitable fucan extraction method?
The preferred method should be able to meet the structural and functional requirements of the desired fucan while being feasible in terms of cost-effectiveness, technical feasibility, and commercial production.
CD BioGlyco has advanced technologies that enable us to produce fucan with a wide range of bioactivities. Our technologies have the potential to maximize the efficiency and yields of marine carbohydrate products, as well as provide long-lasting stability. Please feel free to contact us if you require additional information.
Reference
- Silva, A.K.A.; et al. Anti-inflammatory activity of fucan from Spatoglossum schröederi in a murine model of generalized inflammation induced by zymosan. Marine Drugs. 2023, 21(11): 557.
