Superior Solutions with Fucoidan Production
Fucoidan is a polysaccharide compound and the main component of it is fucose, usually extracted from seaweeds such as brown algae. CD BioGlyco has been delivering expert Marine Carbohydrate Production Services for numerous years, and our Alginate Production Service, Laminarin Production Service, Carrageenan Production Service, and fucoidan production services have garnered praise from our satisfied clientele. Common seaweed sources include Laminaria saccharina, Laminaria digitata, Cladosiphon okamuranus, and Ascophyllum nodosum, etc. Our services encompass the extraction of fucoidan from a variety of seaweeds, including but not limited to the following:
Extraction
- Acid extraction: One of our most commonly employed methods is acid extraction, using dilute acetic acid. The concentration of acid, extraction time, and temperature are crucial factors influencing the yield, sulfate, and alginate content of the sample. A higher acid concentration can effectively penetrate the cell wall and disrupt the fucoidan structure, while a longer extraction time may reduce the content of alginate and sulfate, resulting in lower-quality fucoidan. Our experts select the most appropriate concentration based on specific circumstances.
- Enzymatic Extraction: We utilize enzymatic methods for the extraction of fucoidans. The seaweed undergoes pretreatment with a methanol, chloroform, and water mixture to remove low molecular components. Subsequently, the pre-treated seaweed is enzymatically digested using a specifically selected enzyme based on the structure of target fucoidans. The enzymatic products are filtered to remove residues and solid particles, followed by the separation of fucoidans from solution through centrifugation, chromatography, and other techniques. Finally, isolated fucoidans are purified through precipitation, dissolution, and reprecipitation.
Purification
To further improve the purity of fucoidan, we utilize techniques such as ion exchange chromatography (IEC) and gel permeation chromatography (GPC) for additional purification. IEC takes advantage of the electrostatic interaction between the quaternary ammonium groups on the polymer backbone and the anionic groups in the sample for separation. GPC, on the other hand, removes salts from the sample. In addition, we also choose to use dialysis membranes for further purification based on specific sample requirements, effectively eliminating small molecule impurities and reducing salt content.
Publication
Technology: IEC, GPC, and dialysis
Journal: Marine drugs
IF: 5.4
Published: 2022
Results: This article discusses the structure and extraction techniques of fucoidan and its role as an immunomodulator. The article provides a detailed description of the structure of fucoidan, including the composition and linkage of its polysaccharide chains. Meanwhile, the article also discusses different extraction techniques, including water extraction, acid extraction, and enzymatic extraction, and compares their effects, advantages, and disadvantages. To improve the purity, further purification is carried out by techniques such as IEC, GPC, and dialysis. In addition, the article discusses the mechanism of action of fucoidan as an immunomodulator, including its effects on immune cells as well as its anti-inflammatory and anti-tumor activities.
Fig.1 Variety in the structure of fucose that contains sulfated polysaccharides. (Jayawardena, et al., 2022)
Applications
- In cosmetics, fucoidan is used in skin care products for its moisturizing, antioxidant, and anti-inflammatory properties.
- Fucoidan is used in food research to study its potential for use in functional foods, such as nutritional supplements or additives.
- It is used in digestive health research to explore its effects on the digestive system, including regulating intestinal flora, suppressing inflammation, and promoting gut health.
Advantages
- Our advanced extraction technology efficiently extracts high-purity fucoidan from seaweed, maximizing its biological activity and functionality.
- Through optimized extraction and processing, we preserve the bioactive ingredients and ensure the maximum efficacy of our products.
- Our technology is adaptable and versatile as it can be extracted from different types of seaweed, thus enabling us to select the most suitable source of seaweed according to market demand.
Frequently Asked Questions
Which types of seaweed can fucoidan be extracted from?
Fucoidan is mainly extracted from brown seaweeds, such as brown seaweeds, kelp, rockweed, etc. The content and extraction method may vary slightly among different types of seaweeds.
How is the stability of fucoidan?
The stability of fucoidan is affected by many factors, including light and oxygen sensitivity, temperature, pH, moisture, and chemical handling. To maintain its stability, it is recommended that it be stored in the dark, at ambient or low temperatures, avoiding high temperatures and drastic temperature changes, and that packaging materials and handling processes be controlled to minimize exposure to light, oxygen, and moisture to maintain its long-term biological activity and efficacy.
CD BioGlyco utilizes advanced and scientific techniques for the extraction of unique and valuable fucoidan. Our dedication to sustainability and excellence motivates us to continually improve our processes and products, ensuring that we provide optimal solutions for our clients. If you are interested in our services, please feel free to contact us.
Reference
- Jayawardena, T.U.; et al. A review on fucoidan structure, extraction techniques, and its role as an immunomodulatory agent. Marine drugs. 2022, 20(12): 755.
