Unlocking the Power of Agminosides Through Expert Production Services
Agminosides, a group of glycolipids with natural acetylation, were discovered in the New Zealand sponge Raspailia agminata. These compounds possess intricate structures that include as many as six glucose residues partially acetylated. CD BioGlyco has a wealth of experience in Marine Glycolipid Production and provides our clients with a trusted Marine Atypical Glycolipid Production Service. The marine atypical glycolipid we produce including but not limited to Ancorinoside, Bartoloside, Clathroside, Discoside, and agminoside. The process of our professional agminoside production service is as follows.
Agminoside Extraction
Firstly, we select marine plants rich in agminoside for extraction and clean the plants to remove impurities and seawater. Subsequently, we pulverize the cleaned plant to increase the extraction efficiency. Subsequently, supercritical carbon dioxide (SC-CO2) extraction, ultrasonic-assisted extraction (UAE), or microwave-assisted extraction (MAE) are used to extract the agminoside-containing components. The extract is separated from the target components such as agminoside by membrane separation or chromatographic separation techniques to remove impurities, and the separated agminoside is concentrated and purified to increase the purity and concentration.
Isolation and Structural Characterization
- Our experts perform acid hydrolysis of the mixed agminosides to hydrolyze the sugar fraction to monosaccharides. Subsequently, we subject the hydrolyzed sugar to reductive amination reaction and gas chromatography (GC) mass spectrometry analysis of the product and compare it with known D-glucose standards to confirm the sugar fraction as D-glucose.
- The presence of the relevant isomers is observed after analyzing the product by high-resolution electrospray ionization mass spectrometry (HRESIMS) in negative ion mode.
- Subsequently, we isolate and structurally characterize the agminosides using HRESIMS in negative ion mode and 1H and 13C NMR spectroscopy to obtain the structures of several agminosides.
Crystallization and Drying
We dissolve pure agminoside in a suitable amount of solvent, then crystallize and finally dry the collected agminoside crystals by vacuum drying or spray drying to obtain high-purity final agminoside extract.
Publication Data
Technology: Natural compound isolation
Journal: Marine Drugs
IF: 5.4
Published: 2018
Results: This article focuses on bioactive glycolipids of marine origin. The article mentions several biologically active glycolipids such as avrainvilloside. The article also describes some studies on the synthetic methods and structure-activity relationships of these compounds. In addition, the article mentions some glycolipids with antitumor activity, such as nigricanosides and ieodoglucomides. The authors also present a series of atypical glycolipids, including the isolation and characterization of agminosides.
Fig.1 Structures of agminosides. (Cheng-Sánchez & Sarabia, 2018)
Applications
- Agminosides can be used as candidate molecules for drug development and are used in the study of antibacterial, anti-inflammatory, anti-tumor, and other diseases.
- Agminosides can be used in studies of cell signaling, growth regulation, cell attachment, and differentiation.
- Certain agminosides may have antioxidant properties that can be used in studies to combat free radical damage and slow down the aging process.
Advantages
- Our advanced production facilities and technology enable us to effectively conduct the production and extraction of marine glycolipids.
- Our R&D team consists of experts in chemistry and biology who are dedicated to researching and developing marine glycolipids.
- Our experts adapt production processes and product formulations to the specific requirements of our clients to meet the needs of different markets and application areas.
Frequently Asked Questions
What are agminosides?
Agminosides are a class of naturally occurring acetylated glycolipids isolated from the New Zealand sponge Raspailia agminated, with a complex chemical structure and diverse biological activities.
How do agminosides differ from other similar marine glycolipid compounds?
Agminosides have specific chemical structural features that typically include multiple acetylated glucose residues. These acetylated groups may be located in different positions or form different linkages, differing from the chemical structure of other marine glycolipids.
To ensure the production of high-quality extracts, CD BioGlyco conducts thorough characterization and analysis of the structural and functional properties of the agminoside molecules we produced. Our tailor-made solutions are designed to meet the specific R&D needs of clients across various industries. Please don't hesitate to contact us!
Reference
- Cheng-Sánchez, I.; Sarabia, F. Chemistry and biology of bioactive glycolipids of marine origin. Marine Drugs. 2018, 16(9): 294.
