Revolutionize Your Research: Custom Marine Acanthacerebroside Production Service
At CD BioGlyco, we are at the forefront of marine biotechnology, innovative solutions that harness the vast potential of oceans. Our Marine Biomolecule Production Services represent a comprehensive suite of advanced processes designed to isolate and purify rare and valuable compounds from marine sources. Within this broad portfolio, our Marine Glycolipid Production Service stands out as a specialized offering, focusing on the extraction and refinement of glycolipids.
Delving deeper into the realm of glycolipids, we introduce our Marine Glycosphingolipid Production Service, which zeroes in on the intricate and highly functional family of glycosphingolipids. Our acanthacerebroside production services are one of the core components of our glycosphingolipid expertise.
Acanthacerebrosides are a rare subclass of glycosphingolipids, renowned for their potential in advancing medical research, drug discovery, and even cosmetics due to their unique bioactivities. Leveraging cutting-edge technologies and rigorous quality control measures, we ensure that our acanthacerebroside production service delivers consistently high-purity and research-grade products tailored to meet the specific needs of our clients across diverse fields.
Extraction and Separation
- Solvent extraction method: We use different solvents to extract acanthacerebroside from marine biological raw materials based on their solubility differences.
- Supercritical fluid extraction (SFE): We use fluids in a supercritical state (such as carbon dioxide) as solvents to extract the raw materials. Supercritical fluids have excellent solubility and permeability, and can efficiently extract acanthacerebroside.
- Microwave-assisted extraction (MAE): We use microwave heating to accelerate the dissolution and diffusion of the acanthacerebroside in the raw material by the solvent, thereby improving the extraction efficiency.
Purification
- High-performance liquid chromatography (HPLC): This technology uses a high-pressure pump to inject the solvent (mobile phase) into the chromatographic column at a certain flow rate, and the sample interacts with the stationary phase in the column to achieve separation. We optimize the parameters such as column size and flow rate to achieve an efficient and stable purification process.
- Crystallization and recrystallization: We use dissolution, cooling, precipitation, and other steps to precipitate and purify Acanthacerebroside in the form of crystals. Recrystallization is to dissolve and precipitate the initially purified crystals again to improve the purity further.
- Membrane separation technology: This technology uses the selective permeability of the membrane to separate different components in the mixture. In the purification process of acanthacerebroside, membrane separation technology can be used to remove macromolecular impurities or perform preliminary concentration.
Characterization
- Mass spectrometry (MS): This technology is carried out by measuring the mass-to-charge ratio (m/z) and relative abundance of ions in the sample. MS provides molecular weight, molecular formula, and structural information of acanthacerebroside. Commonly used techniques include gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS).
- Nuclear magnetic resonance (NMR) spectroscopy: This technology uses the behavior of atomic nuclei in a magnetic field to study the structure and properties of compounds. NMR provides detailed structural information of acanthacerebroside, including hydrogen spectrum (1H-NMR) and carbon spectrum (13C-NMR).
- Infrared spectroscopy (IR): This technique is carried out by measuring the absorption or transmission of infrared light by the sample. IR provides information about the functional groups in acanthacerebroside.
Publication
Journal: Marine Drugs
IF: 4.9
Published: 2018
Results: The authors briefly describe the discovery of the marine acanthacerebrosides. The authors also describe the isolation of the acanthacerebrosides from the water-insoluble lipid fraction of the chloroform-methanol extract of the starfish Acanthaster planci and their identification as well-defined chemical compositions based on chemical and spectroscopic methods. Reversed-phase HPLC allowed the efficient separation of these cerebrosides and revealed that they were very similar in structure. Negative FABMS spectroscopy helps provide information on the molecular weight of cerebrosides.
Fig.1 The structures of acanthacerebroside. (Cheng-Sánchez & Sarabia, 2018)
Applications of Marine Acanthacerebroside
- Marine acanthacerebroside can be used as a key compound in the bioactivity screening model.
- In the drug development process, marine acanthacerebroside can be used as a lead compound to develop new drug candidates with specific biological activities through structural modification and optimization.
- Exploring the biochemical mechanism of action of marine acanthacerebroside enhances the understanding of complex biochemical processes in marine organisms.
Advantages
- Advanced extraction technology: We have an efficient and environmentally friendly extraction process to maximize the extraction of high-purity marine acanthacerebroside from marine biological resources.
- Continuous R&D and innovation capabilities: We have a strong R&D team that continuously explores and optimizes the extraction and purification technology of marine acanthacerebroside.
- Diversified application scenarios: Based on the unique properties of marine acanthacerebroside, we continue to expand its application areas, such as bioactivity screening, drug compound discovery, and biomaterial modification to meet the diverse needs of the market.
Frequently Asked Questions
Can your company customize the production of marine acanthacerebroside to meet client needs?
Of course. We have flexible production capabilities and a professional R&D team to customize production according to the specific needs of clients. Whether it is adjusting product specifications, purity requirements, or exploring new application areas, we wholeheartedly provide clients with personalized solutions.
Does your company provide technical support and consulting services for marine acanthacerebroside?
Our technical team has rich professional knowledge and practical experience to answer questions about marine acanthacerebroside for clients, including product characteristics, application areas, and usage methods. In addition, we also provide customized solutions and technical support services to help clients better use marine acanthacerebroside for scientific research or product development.
CD BioGlyco is always client-centric and is committed to providing high-quality and customized acanthacerebroside production services. We look forward to working with partners around the world to jointly promote the development of acanthacerebroside in multiple fields. Please feel free to contact us for more details if you are interested in our acanthacerebroside production service!
Reference
- Cheng-Sánchez, I.; Sarabia, F. Chemistry and biology of bioactive glycolipids of marine origin. Marine Drugs. 2018, 16(9): 294.
