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Agelagalastatin is a neutral Glycosphingolipid with oligosaccharide chains from the marine sponge Agelas sp. It has attracted the attention of biologists and chemists because of its immunomodulatory activity. CD BioGlyco has a strong team of specialists dedicated to research on the Production of Marine Glycolipid to provide custom agelagalastatin production solutions to a wide range of clients.
The marine sponge is crushed and an appropriate amount of methanol is added to it to extract the agelagalastatin. The mixture of methanol and agelagalastatin is centrifuged and subsequently filtered and the filtrate is collected. Next, the filtrate is extracted using solvents such as CH2Cl2, hexane, and water, and the organic phase is collected. Finally, the organic phase is concentrated and freeze-dried to give a crude product of agelagalastatin.
The crude agelagalastatin obtained is dissolved in dichloromethane and purified using a series of gel permeation chromatography (GPC), and liquid chromatography (LC). In this process, gradient elution is used. Finally, the eluate containing the agelagalastatin fraction is collected and concentrated to obtain agelagalastatin.
In addition to the production methods mentioned above, we also perform chemical synthesis of agelagalastatin according to the specific experimental needs of our clients. For example, we use a ceramide derivative as the substrate, catalyzed by inorganic metal salts, through a series of selective glycosylation reactions to complete the preparation of agelagalastatin.
Technology: Solvent extraction, NMR
Journal: Marine Drugs
IF: 4.9
Published: 2018
Results: In this article, the authors describe the extraction method, structural characterization, and biological activity of agelagalastatin from a marine sponge. Agelagalastatin was extracted from Agelas sp. using methanol. It was analyzed by NMR for its structural characteristics, i.e., it contains an unprecedented number of difuranosyl units. In addition, agelagalastatin exhibited significant in vitro antitumor activity against several types of human cancer cells, such as brain SF-295 cells and colon KM20L2 cells.
Fig.1 Structure of agelagalastatin. (Cheng-Sánchez & Sarabia, 2018)
What is agelagalastatin?
Agelagalastatin is a class of biologically active compounds isolated from marine sponges, which belong to a class of neutral glycosphingolipids with oligosaccharide chains. Agelagalastatin contains a special structure of bis-galactose-furanose residues, which are widely used in drug discovery and disease research.
What are the biological activities of agelagalastatin?
Agelagalastatin has a variety of biological activities, including but not limited to:
CD BioGlyco has excellent technical advantages and rich experience in the field of agelagalastatin production. Our professional team is dedicated to providing clients with efficient and reliable agelagalastatin production services to ensure the quality of our products and the stability of our production process. Please feel free to
if you need more information related to marine glycolipids.Reference